Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanostructures with Living Cells

Using a laser beam (red), a three dimensional grid can be produced, which keeps the cell in place.
Using a laser beam (red), a three dimensional grid can be produced, which keeps the cell in place.

Abstract:
Using Laser Technology, Aleksandr Ovsianikov from the Vienna University of Technology wants to create microstructures with embedded living cells. This project will be funded by an ERC Starting Grant.

Nanostructures with Living Cells

Vienna, Austria | Posted on February 6th, 2013

The behavior of cells strongly depends on their environment. If they are to be researched and manipulated, it is crucial to embed them in suitable surroundings. Aleksandr Ovsianikov is developing a laser system, which allows living cells to be incorporated into intricate taylor-made structures, similar to biological tissue, in which cells are surrounded by the extracellular matrix. This technology is particularly important for artificially growing biotissue, for finding new drugs or for stem cell research. Ovsianikov has now been awarded the ERC Starting Grant from the European Research Council (ERC) of approximately 1.5 million Euros.

High-Tech-Structures for Biomedical Research

"Growing cells on a flat surface is easy, but such cell cultures often behave differently from the cells in a real three dimensional tissue", says Aleksandr Ovsianikov. While in two dimensions, conventional Petri dishes are used, no standard system has yet been available for three dimensional cell cultures. Such a 3D-matrix needs to be porous, so that the cells can be supplied with all the necessary nutrients. Furthermore, it is important that the geometry, chemical and mechanical parameters of this matrix can be precisely adjusted in order to study and induce necessary cell responses. Also, it is important that the structure can be produced quickly and in large quantities, as biological experiments usually have to be carried out in many cell cultures at the same time to yield reliable data.

These requirements are met very well by the research group "Additive Manufacturing Technologies" at the Vienna University of Technology. The interdisciplinary team of researchers has been developing special technologies to create three dimensional structures with precision on a sub-micrometer scale. "We want to develop a universal method, which can serve as a standard for three dimensional cell cultures and which can be adapted for different kinds of tissue and different kinds of cells", says Aleksandr Ovsianikov.

Laser Turns Liquid into Taylor-Made Scaffold

At first, the cells are suspended in a liquid, which mainly consists of water. Cell-friendly molecules are added, which react with light in a very special way: a focused laser beam breaks up double bonds at exactly the right places. A chemical chain reaction then causes the molecules to bond and create a polymer.

This reaction is only triggered when two laser photons are absorbed at the same time. Only within the focal point of the laser beam the density of photons is high enough for that. Material outside the focal point is not affected by the laser. "That is how we can define with unprecedented accuracy, at which points the molecules are supposed to bond and create a solid scaffold", explains Ovsianikov.

Guiding the focus of the laser beam through the liquid, a solid structure is created, in which living cells are incorporated. The surplus molecules which are not polymerized are simply washed away afterwards. This way, a hydrogel structure can be built, similar to the extracellular matrix which surrounds our own cells in living tissue. Ideas from nature are imitated in the lab and used for technological applications. This approach, called ‘bio-mimetics' plays an increasingly important role, especially in materials science. Aleksandr Ovsianikov is confident that in many cases, this technology will render animal testing unnecessary and yield much quicker and more significant results.

Turning Stem Cells into Tissue

Stem cell research is a particularly interesting field of application for the new technology. "It is known that stem cells can turn into different kinds of tissue, depending on their environment", says Aleksandr Ovsianikov. "On top of a hard surface, they tend to develop into bone cells, on a soft substrate they may turn into neurons." In the laser-generated 3D structure the rigidity of the substrate can be tuned so that different types of tissue can be created.

Lithuania, Germany, Austria

Interdisciplinary cooperation is crucial for this project, which connects engineering, material science, biology and chemistry. The possibility to work with experts in such a wide range of scientific fields at one single research facility was an important reason for Aleksandr Ovsianikov to come and work at the Vienna University of Technology. Born in Lithuania, Ovsianikov obtained his PhD in Hannover, Germany. Now he has been working at the Vienna University of Technology for two years.

Aleksandr Ovsianikov's project has now been awarded an ERC Starting Grant from the European Research Council. These grants aim to support up-and-coming researchers who have the proven potential of becoming independent research leaders. Within the next five years, Ovsianikov has the opportunity to establish his own research team and continue his quest to bring together materials science, physics and cell biology.

####

About Vienna University of Technology, TU Vienna
With its eight faculties - mathematics and geo-information, physics, technical chemistry, informatics, civil engineering, architecture and regional planning, mechanical engineering and business science, electrical engineering and information technology – the Vienna University of Technology covers the classic engineering disciplines.

The TU Vienna has a great pool of specialists who are acting in a wide range of different topics in research, teaching and as partners of the economy. More than 2000 scientists do their research and teaching at highly advanced and modern institutes – in summary about 70. Although fundamental research has priority at the TU Vienna applied research is also done. Moreover services are offered as high-tech problem solving and examination expertise for industry and economy. Innovation orientated companies are highly interested in co-operating with the Vienna University of Technology because of its high-tech and high-quality research and its openness for requests of the economy.

The Vienna University of Technology puts great emphasis on co-operation between its own institutes as well as with other universities. Therefore the TU Vienna participates in several European Union (EU) and other research programmes.

The aim of the university was and still is to belong to the best. The effort to reach this aim is also expressed in its mission statement: With the aim of providing technology for people, our mission is to develop scientific excellence and wide-ranging competence in our students.

For more information, please click here

Contacts:
Bettina Neunteufl
+43 (1) 58801 41025


Dr. Aleksandr Ovsianikov
Institute of Materials Science and Technology
Vienna University of Technology
Favoritenstr. 9-11, 1040 Wien
T: +43-1-58801-30830

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Review-article about Aleksandr Ovsianikovs research on Expert Reviews:

Related News Press

News and information

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Announcements

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

QD Vision Wins Prestigious Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency October 16th, 2014

Beyond LEDs: Brighter, new energy-saving flat panel lights based on carbon nanotubes - Planar light source using a phosphor screen with highly crystalline single-walled carbon nanotubes (SWCNTs) as field emitters demonstrates its potential for energy-efficient lighting device October 14th, 2014

Nanobiotechnology

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Photonics/Optics/Lasers

Physicists build reversible laser tractor beam October 20th, 2014

Magnetic mirrors enable new technologies by reflecting light in uncanny ways October 16th, 2014

IRLYNX and CEA-Leti to Streamline New CMOS-based Infrared Sensing Modules Dedicated to Human-activities Characterization October 15th, 2014

Nanodevices for clinical diagnostic with potential for the international market: The development is based on optical principles and provides precision and allows saving vital time for the patient October 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE