Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > A nano-gear in a nano-motor inside you: A molecular mechanism for generation of large force inside cells

A phagosome transported inside a living cell by molecular motors is held by a laser trap. This allows measurement of the picoNewton forces exerted by motors as they haul the phagosome inside the cell.

Credit: Sukant Saran, TIFR
A phagosome transported inside a living cell by molecular motors is held by a laser trap. This allows measurement of the picoNewton forces exerted by motors as they haul the phagosome inside the cell.

Credit: Sukant Saran, TIFR

Abstract:
To live is to move. You strike to swat that irritable mosquito, which skilfully evades the hand of death. How did that happen? Who moved your hand, and what saved the mosquito? Enter the Molecular Motors, nanoscale protein-machines in the muscles of your hand and wings of the mosquito. You need these motors to swat mosquitoes, blink your eyes, walk, eat, drink... just name it. Millions of motors tug as a team within your muscles, and you swat the mosquito. This is teamwork at its exquisite best.

A nano-gear in a nano-motor inside you: A molecular mechanism for generation of large force inside cells

India | Posted on January 17th, 2013

Paradoxically, a weak and inefficient motor (called dynein) is the one that generates large forces in many different biological processes. Why has nature made this counter-intuitive choice? Scientists at TIFR, led by Dr. Roop Mallik, have discovered that a team of dyneins is able to share a load much larger than any one of them can handle, due to the unique ability of each dynein to change gears. Because of this, dynein's do much better at teamwork than other stronger motors that cannot change gears. This work will be published in the top-tier journal Cell in January 2013.

This is the PhD thesis work of Arpan Rai, who was ably supported by members of Mallik's team, Ashim Rai, Avin Ramaiya and Rupam Jha. This group of young students took a laser beam and focused it down to a tiny spot inside a mouse cell. Small objects inside the cell which were being moved around by motors could be trapped in this laser beam. Now, the motors tried their best to pull this object out of this "laser trap". The figure shows an artist's rendition of such an object being pulled out of the laser trap by four dynein motors. Mallik says: "Each dynein showed a special ability to shift gears, just like you shift gears in your car to go uphill. Therefore, each dynein in a team could speed up or slow down, depending how hard it was pulled back. This allowed the dyneins to bunch close together as they were pulling. The bunching helped dyneins to share their load equitably, and therefore work efficiently to generate large forces. Remarkably, motor-teams made up of another motor (called kinesin) which is much stronger than dynein, could not generate comparable forces. The reason? Well Ö you guessed it right. Kinesin does not have a gear!!"

Taken together, these new studies show that Nature may have learnt how to use the gear in a motor much before we made our Ferrari's and Lamborghini's. But, what boggles the mind is that dynein's gear works on a size scale that is ten-million times smaller than the Ferrari's gear.

####

For more information, please click here

Contacts:
Roop Malik

91-222-278-2702

Copyright © Tata Institute of Fundamental Research

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Creation of coherent states in molecules by incoherent electrons October 21st, 2017

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

Molecular Machines

How to draw electricity from the bloodstream: A one-dimensional fluidic nanogenerator with a high power-conversion efficiency September 11th, 2017

First 3-D observation of nanomachines working inside cells: Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3-D the protein machinery inside living cells January 27th, 2017

Micro-bubbles make big impact: Research team develops new ultrasound-powered actuator to develop micro robot November 25th, 2016

Scientists come up with light-driven motors to power nanorobots of the future: Researchers from Russia and Ukraine propose a nanosized motor controlled by a laser with potential applications across the natural sciences and medicine November 11th, 2016

Nanomedicine

Spinning strands hint at folding dynamics: Rice University lab uses magnetic beads to model microscopic proteins, polymers October 17th, 2017

Arrowhead Pharmaceuticals to Present Preclinical Data on ARO-AAT at The Liver Meeting(R) October 10th, 2017

Arrowhead to Present at Chardan Gene Therapy Conference October 3rd, 2017

'CRISPR-Gold' fixes Duchenne muscular dystrophy mutation in mice October 3rd, 2017

Discoveries

Creation of coherent states in molecules by incoherent electrons October 21st, 2017

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

MIPT scientists revisit optical constants of ultrathin gold films October 20th, 2017

Announcements

Creation of coherent states in molecules by incoherent electrons October 21st, 2017

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Strange but true: turning a material upside down can sometimes make it softer October 20th, 2017

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project