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Iranian researchers produced new nanobiosensors by designing and manufacturing appropriate bed for the stabilization of one of four-chain DNA structures entitled G-quadruplex in order to identify compounds attaching to this structure through various mechanisms.
This structure helps the design and diagnosis of anti-cancer drugs, and therefore, it can present a more effective medicine in the treatment of cancer.
DNA special structures consist of genomes in specific areas, and they are in charge of various duties. One of these structures is a four-chain DNA structure called G-quadruplex, which is formed around telomere zone and controls telomerase enzyme. The harness of this enzyme is one of the solutions for the treatment of cancer. Therefore, some medicines have been and are designed to detect this structure and to make connection with it in order to stabilize it.
In the recent research, one of the four-chain DNA structures called G-quadruplex that was deposited on a nano bed was used as a detector of the compounds attached to the structure through various mechanisms.
"In the first stage, we studied the designing and production of a nanobiosensor that can detect the medicine attached to this specific DNA structure. Then, the mechanism of the interactions between the medicines was determined by using electrochemical data obtained in the research. The reason was the fact that medicines and materials can connect to the structure through various methods, and cause various biological effects. Therefore, not only the interaction with this structure but also the determination of the connection mechanism is important. Results showed that the nanobiosensor can be used for this purpose too," Bathani, one of the researchers of the plan, stated.
Results of the research have been published on 1 November 2012 in Electrochimica Acta, vol. 82. For more information about the details of the research, visit pages 143-151 on the same journal.
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