Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Chemistry resolves toxic concerns about carbon nanotubes

Abstract:
Safety fears about carbon nanotubes, due to their structural similarity to asbestos, have been alleviated following research showing that reducing their length removes their toxic properties.

Chemistry resolves toxic concerns about carbon nanotubes

London, UK | Posted on January 15th, 2013

In a new study, published today in the journal Angewandte Chemie, evidence is provided that the asbestos-like reactivity and pathogenicity reported for long, pristine nanotubes can be completely alleviated if their surface is modified and their effective length is reduced as a result of chemical treatment.

First atomically described in the 1990s, carbon nanotubes are sheets of carbon atoms rolled up into hollow tubes just a few nanometres in diameter. Engineered carbon nanotubes can be chemically modified, with the addition of chemotherapeutic drugs, fluorescent tags or nucleic acids - opening up applications in cancer and gene therapy.

Furthermore, these chemically modified carbon nanotubes can pierce the cell membrane, acting as a kind of 'nano-needle', allowing the possibility of efficient transport of therapeutic and diagnostic agents directly into the cytoplasm of cells.

Among their downsides however, have been concerns about their safety profile. One of the most serious concerns, highlighted in 2008, involves the carcinogenic risk from the exposure and persistence of such fibres in the body. Some studies indicate that when long untreated carbon nanotubes are injected to the abdominal cavity of mice they can induce unwanted responses resembling those associated with exposure to certain asbestos fibres.

In this paper, the authors describe two different reactions which ask if any chemical modification can render the nanotubes non-toxic. They conclude that not all chemical treatments alleviate the toxicity risks associated with the material. Only those reactions that are able to render carbon nanotubes short and stably suspended in biological fluids without aggregation are able to result in safe, risk-free material.

Professor Kostas Kostarelos, Chair of Nanomedicine at the UCL School of Pharmacy who led the research with his long term collaborators Doctor Alberto Bianco of the CNRS in Strasbourg, France and Professor Maurizio Prato of the University of Trieste, Italy, said: "The apparent structural similarity between carbon nanotubes and asbestos fibres has generated serious concerns about their safety profile and has resulted in many unreasonable proposals of a halt in the use of these materials even in well-controlled and strictly regulated applications, such as biomedical ones. What we show for the first time is that in order to design risk-free carbon nanotubes both chemical treatment and shortening are needed."

He added: "Creative strategies to identify the characteristics that nanoparticles should possess in order to be rendered 'safe-for-use', and the ways to achieve that, are essential as nanotechnology and its tools are maturing into applications and becoming part of our everyday lives."

####

About University College London - UCL
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender and the first to provide systematic teaching of law, architecture and medicine.

We are among the world's top universities, as reflected by our performance in a range of international rankings and tables. According to the Thomson Scientific Citation Index, UCL is the second most highly cited European university and the 15th most highly cited in the world.

UCL has nearly 25,000 students from 150 countries and more than 9,000 employees, of whom one third are from outside the UK. The university is based in Bloomsbury in the heart of London, but also has two international campuses – UCL Australia and UCL Qatar. Our annual income is more than £800 million.

www.ucl.ac.uk | Follow us on Twitter @uclnews | Watch our YouTube channel YouTube.com/UCLTV

For more information, please click here

Contacts:
Professor Kostas Kostarelos
tel: +44 (0)207 753 5956


Clare Ryan
UCL Media Relations Office
tel: +44 (0)20 3108 3846
mobile: +44 07747 556 056
out of hours +44 (0)7917 271 364

Copyright © University College London

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The paper is published online here:

Related News Press

News and information

Oxford Instruments’ Triton Cryofree dilution refrigerator selected by Oxford University for developing scalable quantum nanodevices September 2nd, 2015

JEOL Introduces New Best-in-Class Field Emission SEM September 2nd, 2015

TCL and QD Vision Demonstrate the Future of Wide Color Gamut Television at IFA: Color IQ Based Display is the First Commercially-Branded Television to Present Over 90% of ITU Rec. 2020 Color Gamut September 2nd, 2015

Atomic Force Microscopes from Asylum Research Guide the Development of Thin Film Deposition and Etch Processes September 2nd, 2015

Chemistry

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Laser-burned graphene gains metallic powers: Rice University scientists find possible replacement for platinum as catalyst August 20th, 2015

Nanotubes/Buckyballs/Fullerenes

For 2-D boron, it's all about that base: Rice University theorists show flat boron form would depend on metal substrates September 2nd, 2015

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Developing Component Scale Composites Using Nanocarbons August 26th, 2015

Southampton scientists find new way to detect ortho-para conversion in water August 25th, 2015

Discoveries

For 2-D boron, it's all about that base: Rice University theorists show flat boron form would depend on metal substrates September 2nd, 2015

Silk bio-ink could help advance tissue engineering with 3-D printers September 2nd, 2015

Phagraphene, a 'relative' of graphene, discovered September 2nd, 2015

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

Announcements

For 2-D boron, it's all about that base: Rice University theorists show flat boron form would depend on metal substrates September 2nd, 2015

Silk bio-ink could help advance tissue engineering with 3-D printers September 2nd, 2015

Phagraphene, a 'relative' of graphene, discovered September 2nd, 2015

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

Safety-Nanoparticles/Risk management

Sustainable nanotechnology center September 1st, 2015

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Warning to DIY enthusiasts & construction workers as dangerous dust emissions August 19th, 2015

Bionic liver micro-organs explain off-target toxicity of acetaminophen (Tylenol): Israeli-German partnership aims to replace animal experiments with advanced liver-on-chip devices August 17th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic