Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

This image shows carbon nanofibers embedded in the elastic membrane.
This image shows carbon nanofibers embedded in the elastic membrane.

Abstract:
"Transfer of Vertically Aligned Carbon Nanofibers to Polydimethylsiloxane (PDMS) while Maintaining their Alignment and Impalefection Functionality"

Authors: Ryan C. Pearce, Justin G. Railsback, Bryan D. Anderson, Mehmet F. Sarac, Joseph B. Tracy, Anatoli V. Melechko, North Carolina State University; Timothy E. McKnight, Oak Ridge National Laboratory

Published: online January 2013, ACS Applied Materials & Interfaces

Abstract: Vertically aligned carbon nanofibers (VACNFs) are synthesized on Al 3003 alloy substrates by direct current plasma-enhanced chemical vapor deposition. Chemically synthesized Ni nanoparticles were used as the catalyst for growth. The Si-containing coating (SiNx) typically created when VACNFs are grown on silicon was produced by adding Si microparticles prior to growth. The fiber arrays were transferred to PDMS by spin coating a layer on the grown substrates, curing the PDMS, and etching away the Al in KOH. The fiber arrays contain many fibers over 15 µm (long enough to protrude from the PDMS film and penetrate cell membranes) and SiNx coatings as observed by SEM, EDX, and fluorescence microscopy. The free standing array in PDMS was loaded with pVENUS-C1 plasmid and human brain microcapillary endothelial (HBMEC) cells and was successfully impalefected.

Researchers Create Flexible, Nanoscale ‘Bed of Nails’ for Possible Drug Delivery

Raleigh, NC | Posted on January 15th, 2013

Researchers at North Carolina State University have come up with a technique to embed needle-like carbon nanofibers in an elastic membrane, creating a flexible "bed of nails" on the nanoscale that opens the door to development of new drug-delivery systems.

The research community is interested in finding new ways to deliver precise doses of drugs to specific targets, such as regions of the brain. One idea is to create balloons embedded with nanoscale spikes that are coated with the relevant drug. Theoretically, the deflated balloon could be inserted into the target area and then inflated, allowing the spikes on the balloon's surface to pierce the surrounding cell walls and deliver the drug. The balloon could then be deflated and withdrawn.

But to test this concept, researchers first needed to develop an elastic material that is embedded with these aligned, nanoscale needles. That's where the NC State research team came in.

"We have now developed a way of embedding carbon nanofibers in an elastic silicone membrane and ensuring that the nanofibers are both perpendicular to the membrane's surface and sturdy enough to impale cells," says Dr. Anatoli Melechko, an associate professor of materials science and engineering at NC State and co-author of a paper on the work.

The researchers first "grew" the nanofibers on an aluminum bed, or substrate. They then added a drop of liquid silicone polymer. The polymer, nanofibers and substrate were then spun, so that centrifugal force spread the liquid polymer in a thin layer between the nanofibers - allowing the nanofibers to stick out above the surface. The polymer was then "cured," turning the liquid polymer into a solid, elastic membrane. Researchers then dissolved the aluminum substrate, leaving the membrane embedded with the carbon nanofibers "needles."

"This technique is relatively easy and inexpensive," says Melechko, "so we are hoping this development will facilitate new research on targeted drug-delivery methods."

The paper, "Transfer of Vertically Aligned Carbon Nanofibers to Polydimethylsiloxane (PDMS) while Maintaining their Alignment and Impalefection Functionality," is published online in the journal ACS Applied Materials & Interfaces. Lead authors on the paper are Ryan Pearce, a Ph.D. student at NC State, and Justin Railsback, a former NC State student now pursuing a Ph.D. at Northwestern University. Co-authors are Melechko; Dr. Joseph Tracy, an assistant professor of materials science and engineering at NC State; Bryan Anderson and Mehmet Sarac, Ph.D. students at NC State; and Timothy McKnight of Oak Ridge National Laboratory.

The research was supported by the National Science Foundation and the Department of Defense, Defense Threat Reduction Agency.

-shipman-

####

For more information, please click here

Contacts:
Matt Shipman
News Services
919.515.6386


Dr. Anatoli Melechko
919.515.8636

Copyright © North Carolina State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Paper - “Transfer of Vertically Aligned Carbon Nanofibers to Polydimethylsiloxane (PDMS) while Maintaining their Alignment and Impalefection Functionality.”:

Related News Press

News and information

Nanofiltration Membrane Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nanozirconia Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Self-Healing Nano Anti-rust Coatings Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nano Spray Instrument Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Govt.-Legislation/Regulation/Funding/Policy

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universität Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

IEEE Photonics Society Applauds Rochester on Integrated Photonics Institute Win July 30th, 2015

Take a trip through the brain July 30th, 2015

Nanomedicine

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

Take a trip through the brain July 30th, 2015

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Discoveries

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universität Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Controlling Dynamic Behavior of Carbon Nanosheets in Structures Made Possible July 30th, 2015

Announcements

Nano Spray Instrument Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nanocellulose Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universität Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

Military

Take a trip through the brain July 30th, 2015

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project