Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > City Tech Professor Helps Discover Groundbreaking Virus Detection Method

Abstract:
Vasily Kolchenko, associate professor of biological sciences at New York City College of Technology (City Tech), is a key player on a research team that recently made a breakthrough with enormous potential significance for the treatment of serious diseases.

City Tech Professor Helps Discover Groundbreaking Virus Detection Method

Brooklyn, NY | Posted on December 19th, 2012

Their work has made it possible, for the first time, to detect the smallest virus particle. Since even one viral particle can represent a deadly threat, the research likely will make an important contribution to ongoing research on early detection of such diseases as AIDS and cancer.

Until the research team announced their discovery this year in Applied Physics Letters (July 27, 2012, American Institute of Physics), no instrument or methodology had been successful in reliably and accurately detecting a single virus particle, which is in the size range of a nanoparticle. (About 80,000 nanoparticles side by side would have the same width as a human hair.)

The research will potentially have an immense impact on the general public, aiding disease detection at its earliest stage when fewer pathogens are present and medical intervention can be most effective. This new approach also has possible applications in the identification of numerous molecules, especially proteins, which are important for drug development research, both as the targets and the treatments.

While scientists have long used microscopes to view objects as small as bacteria, viruses are much smaller. Even the most sensitive electron microscopes, which are cumbersome, expensive and difficult to operate, cannot guarantee detection of these tiny particles.

The team's breakthrough involved adding a nano-antenna to the light-sensing device to enhance the signal. "The idea that light can ‘sense' the presence of nanoparticles and respond to their arrival was groundbreaking," Dr. Kolchenko says.

"Since all the deadliest viruses and most interesting biological molecules -- proteins and DNA -- belong to the nano world, our research proved truly innovative, and its promise is almost unlimited in terms of detecting pretty much everything of interest in life sciences," he adds.

Dr. Kolchenko, who has a medical degree, a doctorate in physiology and a master's degree in mathematics from Kiev University, provided a unique combination of expertise in bioinformatics, mathematics and medicine that was integral to the project's success in isolating the smallest individual RNA virus, MS2.

"I first became interested in pursuing research on using light for the detection and measurement of the tiniest biological and non-living objects when I heard a talk on biosensors that Professor Stephen Arnold of Polytechnic/NYU gave at City Tech," says Dr. Kolchenko, who teaches biology at City Tech and bioinformatics at Polytechnic.

The two-year research project, funded for $400,000 by the National Science Foundation, has been conducted at Polytechnic/NYU's Micro-Particle Laboratory for BioPhotonics, under the direction of Dr. Stephen Arnold, in collaboration with the physics departments of Fordham University and Hunter College, and the biological sciences department of City Tech. Polytechnic/NYU has applied for a utility patent for the team's ground-breaking innovation.

Prior to the latest NSF project, ten years of laboratory research by Dr. Kolchenko and his colleagues resulted in the development of a simple, low-cost design for more sensitive, miniature devices that could detect and measure viruses, proteins and DNA in real time. From 2005 through 2008, the team published papers detailing its progress in such prestigious journals as Applied Physics Letters, Faraday Discussions and Proceedings of the National Academy of Sciences.

"One of the ultimate goals is to develop portable, inexpensive, easy to use and highly sensitive devices for healthcare and research settings," says Dr. Kolchenko. "This research opens the door for highly sensitive detection and measurement of biological and other nanoparticles that are essential in molecular biology, clinical medicine and diagnostics, epidemiology, ecology, nanotechnology and other fields."

Further research is planned, according to Dr. Kolchenko. "Since single protein molecules are much smaller than viral particles, their detection will be the ultimate test of the method," he says. "We hope after some additional research and development, our method will allow for single protein detection as well."

Such research could enable the earlier screening of cancer markers, which are protein molecules produced when cancer grows. Currently, there are several markers that could be potentially detected by the new biosensor; early detection of these markers could allow treatment to begin sooner, enhancing cancer survival rates.

Says Dr. Kolchenko, "We have merely scratched the surface of what is likely to be possible."

####

About The City University of New York (CUNY)
New York City College of Technology (City Tech) of The City University of New York (CUNY) is the largest public college of technology in New York State. Located at 300 Jay Street in Downtown Brooklyn, the College enrolls more than 16,000 students in 63 baccalaureate, associate and specialized certificate programs.

For more information, please click here

Contacts:
Michele Forsten

Copyright © The City University of New York (CUNY)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Researchers discover new chemical sensing technique: Technique allows sharper detail -- and more information -- with near infrared light June 24th, 2016

GraphExeter illuminates bright new future for flexible lighting devices June 23rd, 2016

Soft decoupling of organic molecules on metal June 23rd, 2016

Imaging

Researchers discover new chemical sensing technique: Technique allows sharper detail -- and more information -- with near infrared light June 24th, 2016

Coexistence of superconductivity and charge density waves observed June 23rd, 2016

Nanomedicine

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Stealth nanocapsules kill Chagas parasites in mouse models June 22nd, 2016

New nanoparticle technology developed to treat aggressive thyroid cancer: Platform designed to deliver nanotherapy effective in preclinical models of metastatic anaplastic thyroid cancer June 21st, 2016

Discoveries

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Researchers discover new chemical sensing technique: Technique allows sharper detail -- and more information -- with near infrared light June 24th, 2016

GraphExeter illuminates bright new future for flexible lighting devices June 23rd, 2016

Soft decoupling of organic molecules on metal June 23rd, 2016

Announcements

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Researchers discover new chemical sensing technique: Technique allows sharper detail -- and more information -- with near infrared light June 24th, 2016

GraphExeter illuminates bright new future for flexible lighting devices June 23rd, 2016

Soft decoupling of organic molecules on metal June 23rd, 2016

Tools

Researchers discover new chemical sensing technique: Technique allows sharper detail -- and more information -- with near infrared light June 24th, 2016

Coexistence of superconductivity and charge density waves observed June 23rd, 2016

Soft decoupling of organic molecules on metal June 23rd, 2016

FEI and University of Liverpool Announce QEMSCAN Research Initiative: University of Liverpool will utilize FEI’s QEMSCAN technology to gain a better insight into oil and gas reserves & potentially change the approach to evaluating them June 22nd, 2016

Nanobiotechnology

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Tailored DNA shifts electrons into the 'fast lane': DNA nanowire improved by altering sequences June 22nd, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Stealth nanocapsules kill Chagas parasites in mouse models June 22nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic