- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
|A new-generation nano-platform capable of capturing circulating tumor cells and releasing them at reduced temperature.|
Scientists from the RIKEN Advanced Science Institute in Japan and University of California Los Angeles report a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream.This new nanotechnology could be used for cancer diagnosis and give insight into the mechanisms of how cancer spreads throughout the body. The device provides a convenient and non-invasive alternative to biopsy, the current method for diagnosis of metastatic cancer. It could enable doctors to detect tumor cells that circulate in cancer patients' blood well before they subsequently colonize as tumors in other organs. The device also enables researchers to keep the tumor cells alive and subsequently study them.
The device was developed by a team led by Hsiao-hua Yu from the RIKEN Advanced Science Institute in Japan and Hsian-Rong Tseng from the Department of Molecular and Medical Pharmacology at the University of California Los Angeles, in research published online today in the journal Advanced Materials.
Similar cell-capture devices have been reported but this technology is unique in that it is capable of catching the tumor cells with great efficiency and releasing them with great cell viability. Blood is passed through the device like a filter that contains a molecule capable of adhering to tumor cells like Velcro and separating them with efficiency ranging from 40% to 70%. The cancer cells are retained by tiny temperature-responsive polymer brushes inside the device. At 37 degrees Celsius, these polymer brushes stick to the tumor cells, but when cooled to 4 degrees Celsius, they release them, allowing scientists to examine the cells.
"Until now, most devices have demonstrated the ability to capture circulating tumor cells with high efficiency. However, it is equally important to release these captured cells, to preserve and study them in order to obtain insightful information about them. This is the big difference with our device." Explains Hsiao-hua Yu, who led the team that developed the technique to coat the device with polymer brushes.
Full bibliographic information
Shuang Hou, Haichao Zhao, Libo Zhao, Qinglin Shen, Kevin S. Wei, Daniel Y. Suh, Aiko Nakao, Bin Xiong, Shyh-Chyang Luo,Hsian-Rong Tseng,Hsiao-hua Yu "Capture and Stimulated Release of Circulating Tumor Cells on Polymer-Grafted Silicon Nanostructures." Advanced Materials, 2012
RIKEN is Japan’s flagship research institute devoted to basic and applied research. Over 2500 papers by RIKEN researchers are published every year in reputable scientific and technical journals, covering topics ranging across a broad spectrum of disciplines including physics, chemistry, biology, medical science and engineering. RIKEN’s advanced research environment and strong emphasis on interdisciplinary collaboration has earned itself an unparalleled reputation for scientific excellence in Japan and around the world. Reach us on Twitter: @rikenresearch
About the RIKEN Advanced Science Institute
The RIKEN Advanced Science Institute (ASI) is an interdisciplinary research institute devoted to fostering creative, curiosity-driven basic research and sowing the seeds for innovative new projects. With more than 700 full-time researchers, the ASI acts as RIKEN's research core, supporting inter-institutional and international collaboration and integrating diverse scientific fields including physics, chemistry, engineering, biology and medical science.
For more information, please click here
Global Relations Office
Media Relations Director
Jonsson Comprehensive Cancer Center
Broad Stem Cell Research Center
Direct line: +1 - 310-206-2805
Copyright © AlphaGalileoIf you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
Researchers develop new way to manufacture nanofibers May 21st, 2015
Effective Nano-Micelles Designed in Iran to Treat Cancer May 20th, 2015
Efficiency record for black silicon solar cells jumps to 22.1 percent: Aalto University's researchers improved their previous record by over 3 absolute percents in cooperation with Universitat Politècnica de Catalunya May 18th, 2015
Organic nanoparticles, more lethal to tumors: Carbon-based nanoparticles could be used to sensitize cancerous tumors to proton radiotherapy and induce more focused destruction of cancer cells, a new study shows May 18th, 2015