Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > New Geometries: Researchers Create New Shapes of Artificial Microcompartments - As in nature, various shapes could be more efficient for specific functions

Monica Olvera de la Cruz
Monica Olvera de la Cruz

Abstract:
In nature, biological functions are often carried out in tiny protective shells known as microcompartments, structures that provide home to enzymes that convert carbon dioxide into energy in plant cells and to viruses that replicate once they enter the cell.

New Geometries: Researchers Create New Shapes of Artificial Microcompartments - As in nature, various shapes could be more efficient for specific functions

Chicago, IL | Posted on December 12th, 2012

Most of these shells buckle into an icosahedron shape, forming 20 sides that allow for high interface with their surroundings. But some shells — such as those found in the single-celled Archaea or simple, salt-loving organisms called halophiles —break into triangles, squares, or non-symmetrical geometries. While these alternate geometries may seem simple, they can be incredibly useful in biology, where low symmetry can translate to higher functionality.

Researchers at Northwestern University have recently developed a method to recreate these shapes in artificial microcompartments created in the lab: by altering the acidity of their surroundings. The findings could lead to designed microreactors that mimic the functions of these cell containers or deliver therapeutic materials to cells at specific targeted locations.

"If you want to design a very clever capsule, you don't make a sphere. But perhaps you shouldn't make an icosahedron, either," said Monica Olvera de la Cruz, Lawyer Taylor Professor of Materials Science and Engineering, Chemistry, and (by courtesy) Chemical and Biological Engineering at Northwestern's McCormick School of Engineering and one of the paper's authors. "What we are beginning to realize is maybe these lower symmetries are smarter."

To create the new shell geometries, the researchers co-assembled oppositely charged lipids with variable degrees of ionization and externally modified the surrounding electrolyte. The resulting geometries include fully faceted regular and irregular polyhedral, such as square and triangular shapes, and mixed Janus-like vesicles with faceted and curved domains that resembled cellular shapes and shapes of halophilic organisms.

The research was conducted by three McCormick faculty members: Olvera de la Cruz, Lawyer Taylor Professor of Materials Science and Engineering, Professor of Chemistry, and (by courtesy) Chemical and Biological Engineering; Michael J. Bedzyk, professor of materials science and engineering and (by courtesy) physics and astronomy; and Samuel I. Stupp, Board of Trustees Professor of Materials Science and Engineering, Chemistry, and Medicine.

A paper about the research, "Molecular Crystallization Controlled by pH Regulates Mesoscopic Membrane Morphology," was published November 27 in the journal ACS Nano.

Other authors of the paper include lead co-authors Cheuk-Yui Leung, Liam C. Palmer, and Bao Fu Qiao; Sumit Kewalramani, Rastko Sknepnek, Christina J. Newcomb, and Megan A. Greenfield, all of Northwestern; and Graziano Vernizzi of Siena College.

####

For more information, please click here

Contacts:
Megan Fellman

847-491-3115

Copyright © Northwestern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Article - “Molecular Crystallization Controlled by pH Regulates Mesoscopic Membrane Morphology.”:

Related News Press

News and information

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Nanomedicine

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Discoveries

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Announcements

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Nanobiotechnology

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Implementation of DNA Chains in Designing Nanospin Pieces November 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE