Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > New Geometries: Researchers Create New Shapes of Artificial Microcompartments - As in nature, various shapes could be more efficient for specific functions

Monica Olvera de la Cruz
Monica Olvera de la Cruz

Abstract:
In nature, biological functions are often carried out in tiny protective shells known as microcompartments, structures that provide home to enzymes that convert carbon dioxide into energy in plant cells and to viruses that replicate once they enter the cell.

New Geometries: Researchers Create New Shapes of Artificial Microcompartments - As in nature, various shapes could be more efficient for specific functions

Chicago, IL | Posted on December 12th, 2012

Most of these shells buckle into an icosahedron shape, forming 20 sides that allow for high interface with their surroundings. But some shells — such as those found in the single-celled Archaea or simple, salt-loving organisms called halophiles —break into triangles, squares, or non-symmetrical geometries. While these alternate geometries may seem simple, they can be incredibly useful in biology, where low symmetry can translate to higher functionality.

Researchers at Northwestern University have recently developed a method to recreate these shapes in artificial microcompartments created in the lab: by altering the acidity of their surroundings. The findings could lead to designed microreactors that mimic the functions of these cell containers or deliver therapeutic materials to cells at specific targeted locations.

"If you want to design a very clever capsule, you don't make a sphere. But perhaps you shouldn't make an icosahedron, either," said Monica Olvera de la Cruz, Lawyer Taylor Professor of Materials Science and Engineering, Chemistry, and (by courtesy) Chemical and Biological Engineering at Northwestern's McCormick School of Engineering and one of the paper's authors. "What we are beginning to realize is maybe these lower symmetries are smarter."

To create the new shell geometries, the researchers co-assembled oppositely charged lipids with variable degrees of ionization and externally modified the surrounding electrolyte. The resulting geometries include fully faceted regular and irregular polyhedral, such as square and triangular shapes, and mixed Janus-like vesicles with faceted and curved domains that resembled cellular shapes and shapes of halophilic organisms.

The research was conducted by three McCormick faculty members: Olvera de la Cruz, Lawyer Taylor Professor of Materials Science and Engineering, Professor of Chemistry, and (by courtesy) Chemical and Biological Engineering; Michael J. Bedzyk, professor of materials science and engineering and (by courtesy) physics and astronomy; and Samuel I. Stupp, Board of Trustees Professor of Materials Science and Engineering, Chemistry, and Medicine.

A paper about the research, "Molecular Crystallization Controlled by pH Regulates Mesoscopic Membrane Morphology," was published November 27 in the journal ACS Nano.

Other authors of the paper include lead co-authors Cheuk-Yui Leung, Liam C. Palmer, and Bao Fu Qiao; Sumit Kewalramani, Rastko Sknepnek, Christina J. Newcomb, and Megan A. Greenfield, all of Northwestern; and Graziano Vernizzi of Siena College.

####

For more information, please click here

Contacts:
Megan Fellman

847-491-3115

Copyright © Northwestern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Article - “Molecular Crystallization Controlled by pH Regulates Mesoscopic Membrane Morphology.”:

Related News Press

News and information

Ultra-flat circuits will have unique properties: Rice University lab studies 2-D hybrids to see how they differ from common electronics July 25th, 2016

Attosecond physics: Mapping electromagnetic waveforms July 25th, 2016

Borrowing from pastry chefs, engineers create nanolayered composites: Method to stack hundreds of nanoscale layers could open new vistas in materials science July 25th, 2016

Integration of novel materials with silicon chips makes new 'smart' devices possible July 25th, 2016

Nanomedicine

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

New probe developed for improved high resolution measurement of brain temperature: Improved accuracy could allow researchers to measure brain temperature in times of trauma when small deviations in temperature can lead to additional brain injury July 23rd, 2016

Discoveries

Attosecond physics: Mapping electromagnetic waveforms July 25th, 2016

Borrowing from pastry chefs, engineers create nanolayered composites: Method to stack hundreds of nanoscale layers could open new vistas in materials science July 25th, 2016

Integration of novel materials with silicon chips makes new 'smart' devices possible July 25th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

Announcements

Borrowing from pastry chefs, engineers create nanolayered composites: Method to stack hundreds of nanoscale layers could open new vistas in materials science July 25th, 2016

Integration of novel materials with silicon chips makes new 'smart' devices possible July 25th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

XEI Scientific Partners with Electron Microscopy Sciences to Promote and Sell its Products in North and South America July 25th, 2016

Nanobiotechnology

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

New reaction for the synthesis of nanostructures July 21st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic