Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Fetal risk of nanoparticle exposure assessed

Abstract:
A recent collaborative venture between Chinese scientists from National Center for Nanoscience and Technology, China, and Australian scientists from University of Western Australia and Queensland Institute of Medical Research have uncovered the major factors that govern the materno-fetal transfer of nanoparticles.

Fetal risk of nanoparticle exposure assessed

Germany | Posted on November 29th, 2012

With the accelerating development and use of nanomaterials in cosmetic, medical and pharmaceutical applications, the importance of assessing the potential risks of nanomaterials to human health is growing. As the risk of exposure to nanomaterials in pregnancy increases, so does the opportunity for exposure to the developing fetus - one of the most vulnerable subgroups of society. Accordingly, the materno-fetal transfer of nano-scale substances has become of great interest in assessing the safety of nanomaterials in pregnancy for medical purposesand the associated risk of growth and developmental defects in the fetus. However, there is considerable uncertainty regarding the mechanism, extent and consequence of materno-fetal transfer of nanoparticles.

The research team designed and synthesized a series of 13 nm gold nanoparticles with different surface modifications, either citrate, polymer (PEG) or protein (ferritin protein cage). They then assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. Interestingly, their results showed that a critical time window exists: in early pregnancy, prior to day 11.5 of pregnancy (about half way to term), all three types of nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, after this point fetal gold levels declined dramatically, although placental accumulation continued to increase. Fetal and placental accumulation of ferritin- and PEG-modified nanoparticles was 10-fold greater than citrate-capped nanoparticles. Importantly, despite the significant accumulation of Au nanoparticles in the placenta and developing fetus, no signs of toxicity were observed.

The present study has addressed important issues relating to some of the factors governing placental uptake, passage and fetal exposure. The results suggest one can modify the nanoparticle surface as required to either increase the placental targeting of therapeutic nanoparticles or decrease/avoid unnecessary fetal nanoparticle exposure during development. These novel findings in murine pregnancy have significant biomedical and biosafety implications for nanoparticle administration in pregnancy in humans and may pave the way for developing effective and safe biomedical applications of nanoparticles in pregnancy. Nevertheless, further work is urgently required to assess the importance of species differences and define the mechanisms underlying the variable permeability of nanoparticles across the placental barrier.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper:

Related News Press

News and information

Little ANTs: Researchers build the world's tiniest engine May 3rd, 2016

An Experiment Seeks to Make Quantum Physics Visible to the Naked Eye May 3rd, 2016

Quantum sensors for high-precision magnetometry of superconductors May 3rd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Discoveries

Little ANTs: Researchers build the world's tiniest engine May 3rd, 2016

An Experiment Seeks to Make Quantum Physics Visible to the Naked Eye May 3rd, 2016

Quantum sensors for high-precision magnetometry of superconductors May 3rd, 2016

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Announcements

Little ANTs: Researchers build the world's tiniest engine May 3rd, 2016

An Experiment Seeks to Make Quantum Physics Visible to the Naked Eye May 3rd, 2016

Quantum sensors for high-precision magnetometry of superconductors May 3rd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Safety-Nanoparticles/Risk management

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Scientists propose non-animal tools for assessing the toxicity of nanomaterials: Particle and Fibre Toxicology publishes recommendations from expert group meeting April 26th, 2016

The impact of anti-odor clothing on the environment March 31st, 2016

SUNY Poly, in Collaboration with the George Washington School of Medicine and Health Sciences and Stony Brook University, Demonstrates Pioneering Method to Visualize and Identify Engineered Nanoparticles in Tissue March 25th, 2016

Research partnerships

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic