Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Fetal risk of nanoparticle exposure assessed

Abstract:
A recent collaborative venture between Chinese scientists from National Center for Nanoscience and Technology, China, and Australian scientists from University of Western Australia and Queensland Institute of Medical Research have uncovered the major factors that govern the materno-fetal transfer of nanoparticles.

Fetal risk of nanoparticle exposure assessed

Germany | Posted on November 29th, 2012

With the accelerating development and use of nanomaterials in cosmetic, medical and pharmaceutical applications, the importance of assessing the potential risks of nanomaterials to human health is growing. As the risk of exposure to nanomaterials in pregnancy increases, so does the opportunity for exposure to the developing fetus - one of the most vulnerable subgroups of society. Accordingly, the materno-fetal transfer of nano-scale substances has become of great interest in assessing the safety of nanomaterials in pregnancy for medical purposesand the associated risk of growth and developmental defects in the fetus. However, there is considerable uncertainty regarding the mechanism, extent and consequence of materno-fetal transfer of nanoparticles.

The research team designed and synthesized a series of 13 nm gold nanoparticles with different surface modifications, either citrate, polymer (PEG) or protein (ferritin protein cage). They then assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. Interestingly, their results showed that a critical time window exists: in early pregnancy, prior to day 11.5 of pregnancy (about half way to term), all three types of nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, after this point fetal gold levels declined dramatically, although placental accumulation continued to increase. Fetal and placental accumulation of ferritin- and PEG-modified nanoparticles was 10-fold greater than citrate-capped nanoparticles. Importantly, despite the significant accumulation of Au nanoparticles in the placenta and developing fetus, no signs of toxicity were observed.

The present study has addressed important issues relating to some of the factors governing placental uptake, passage and fetal exposure. The results suggest one can modify the nanoparticle surface as required to either increase the placental targeting of therapeutic nanoparticles or decrease/avoid unnecessary fetal nanoparticle exposure during development. These novel findings in murine pregnancy have significant biomedical and biosafety implications for nanoparticle administration in pregnancy in humans and may pave the way for developing effective and safe biomedical applications of nanoparticles in pregnancy. Nevertheless, further work is urgently required to assess the importance of species differences and define the mechanisms underlying the variable permeability of nanoparticles across the placental barrier.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper:

Related News Press

News and information

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Safety-Nanoparticles/Risk management

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

Human health, wealth require expanded marine science, experts say: In Rome, European experts publish a 'common vision' of priorities for marine research and action through 2020 October 9th, 2014

Coating Nanotubes with Aluminum Oxide Lowers Risk of Lung Injury October 6th, 2014

PEN Inc. Chairman Scott Rickert Announces Company Vision, Product Priorities and Management Team: Webcast Highlights the Launch of PEN October 3rd, 2014

Research partnerships

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE