Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Fetal risk of nanoparticle exposure assessed

Abstract:
A recent collaborative venture between Chinese scientists from National Center for Nanoscience and Technology, China, and Australian scientists from University of Western Australia and Queensland Institute of Medical Research have uncovered the major factors that govern the materno-fetal transfer of nanoparticles.

Fetal risk of nanoparticle exposure assessed

Germany | Posted on November 29th, 2012

With the accelerating development and use of nanomaterials in cosmetic, medical and pharmaceutical applications, the importance of assessing the potential risks of nanomaterials to human health is growing. As the risk of exposure to nanomaterials in pregnancy increases, so does the opportunity for exposure to the developing fetus - one of the most vulnerable subgroups of society. Accordingly, the materno-fetal transfer of nano-scale substances has become of great interest in assessing the safety of nanomaterials in pregnancy for medical purposesand the associated risk of growth and developmental defects in the fetus. However, there is considerable uncertainty regarding the mechanism, extent and consequence of materno-fetal transfer of nanoparticles.

The research team designed and synthesized a series of 13 nm gold nanoparticles with different surface modifications, either citrate, polymer (PEG) or protein (ferritin protein cage). They then assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. Interestingly, their results showed that a critical time window exists: in early pregnancy, prior to day 11.5 of pregnancy (about half way to term), all three types of nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, after this point fetal gold levels declined dramatically, although placental accumulation continued to increase. Fetal and placental accumulation of ferritin- and PEG-modified nanoparticles was 10-fold greater than citrate-capped nanoparticles. Importantly, despite the significant accumulation of Au nanoparticles in the placenta and developing fetus, no signs of toxicity were observed.

The present study has addressed important issues relating to some of the factors governing placental uptake, passage and fetal exposure. The results suggest one can modify the nanoparticle surface as required to either increase the placental targeting of therapeutic nanoparticles or decrease/avoid unnecessary fetal nanoparticle exposure during development. These novel findings in murine pregnancy have significant biomedical and biosafety implications for nanoparticle administration in pregnancy in humans and may pave the way for developing effective and safe biomedical applications of nanoparticles in pregnancy. Nevertheless, further work is urgently required to assess the importance of species differences and define the mechanisms underlying the variable permeability of nanoparticles across the placental barrier.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper:

Related News Press

News and information

Graphene reduces wear of alumina ceramic March 26th, 2015

FEI Technology Award of the German Neuroscience Society Goes to Benjamin Judkewitz of the University of Berlin: Bi-annual award honors excellence in brain research during the German Neuroscience Society’s Annual Meeting, held 18-21 March 2015 March 26th, 2015

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

Hong Kong Investors Bullish on Dais Analytic Invest $5.75M, Provide $60M Contract, and Create New Joint Venture Company March 26th, 2015

Discoveries

Graphene reduces wear of alumina ceramic March 26th, 2015

Quantum compute this -- WSU mathematicians build code to take on toughest of cyber attacks: Revamped knapsack code offers online security for the future March 26th, 2015

Thousands of atoms entangled with a single photon: Result could make atomic clocks more accurate March 26th, 2015

Square ice filling for a graphene sandwich March 26th, 2015

Announcements

Industrial Nanotech, Inc. Announces Next Large Order from the Oil and Gas Industry March 26th, 2015

Quantum compute this -- WSU mathematicians build code to take on toughest of cyber attacks: Revamped knapsack code offers online security for the future March 26th, 2015

Thousands of atoms entangled with a single photon: Result could make atomic clocks more accurate March 26th, 2015

Square ice filling for a graphene sandwich March 26th, 2015

Safety-Nanoparticles/Risk management

NNI Publishes Workshop Report Assessing the Status of EHS Risk Science: Report examines progress three years after the release of the 2011 NNI EHS Research Strategy March 23rd, 2015

Are current water treatment methods sufficient to remove harmful engineered nanoparticle? March 10th, 2015

More study needed to clarify impact of cellulose nanocrystals on health: Few studies explore toxicity of cellulose nanocrystals March 10th, 2015

Colon + septic tank = unique, at times stinky, study: Researchers use lab-scale human colon and septic tank to study impact of copper nanoparticles on the environment March 2nd, 2015

Research partnerships

SUNY Poly & M+W Make Major Announcement: Major Expansion To Include M+W Owned Gehrlicher Solar America Corporation That Will Create up to 400 Jobs to Develop Solar Power Plants at SUNY Poly Sites Across New York State March 26th, 2015

ORNL-led team demonstrates desalination with nanoporous graphene membrane March 25th, 2015

New kind of 'tandem' solar cell developed: Researchers combine 2 types of photovoltaic material to make a cell that harnesses more sunlight March 24th, 2015

UW scientists build a nanolaser using a single atomic sheet March 24th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE