Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > High sensitivity Zetasizer Nano ZSP helps users meet new zeta potential measurement standard for biologics

The folded capillary cell used in the Diffusion Barrier Technique for electrophoretic mobility measurement implemented in the Zetasizer Nano ZSP
The folded capillary cell used in the Diffusion Barrier Technique for electrophoretic mobility measurement implemented in the Zetasizer Nano ZSP

Abstract:
One of the most significant applications for Malvern Instruments' new Zetasizer Nano ZSP dynamic light scattering system is the highly sensitive measurement of the zeta potential, or electrophoretic mobility, of proteins. The instrument delivers unique performance specifications for both size and zeta potential measurement, employing an approach to zeta potential measurement that accords with the latest industry guidance.

High sensitivity Zetasizer Nano ZSP helps users meet new zeta potential measurement standard for biologics

Malvern, UK | Posted on November 16th, 2012

Published during 2012, standard guide ASTM E2865 deals with the measurement of mobility and zeta potential in systems containing biological material such as proteins, DNA, liposomes and other similar organic materials that possess particle sizes in the nanometer scale, below 100 nm. These materials are often labile, especially when subjected to an electric field, and standard electrophoretic techniques can lead to measurement of the resulting aggregates rather than the native material.

It has been shown that much of the aggregation takes place at the electrodes. In the Zetasizer Nano ZSP, use of Malvern's patented Diffusion Barrier Technique protects the sample by isolating it from the electrode, as recommended in the ASTM standard. Consequently the applied voltage can be switched on for longer periods to generate more reliable measurement data. The method involves the use of a unique, disposable folded capillary cell which allows measurements to be conducted on samples as small as 20 microliters.

The measurement process is simplified by the inclusion of a protein mobility measurement type in the instrument software that controls data acquisition, guides the user through the measurement and assesses and reports on data quality. Additional tools in the software also allow calculation of protein charge, as illustrated here: www.malvern.com/protein-mobility-video

Further details of the benefits of the Diffusion Barrier Technique for protein mobility measurements can be found at www.malvern.com/diffusion-barrier-technique

For full details of ASTM E2865 go to www.astm.org/Standards/E2865.htm

Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd

####

About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical identification. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.

Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.

For more information, please click here

Contacts:
For press information, please contact:
Trish Appleton
Kapler Communications
Phoenix House, Phoenix Park, Eaton Socon
Cambridgeshire, PE19 8EP, UK
Tel: +44 (0)1480 471059
Fax: +44 (0)1480 471069


USA contact:
Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403


Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park, Grovewood Road
Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789

Copyright © Malvern Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Nanomedicine

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

Announcements

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Tools

Exploring phosphorene, a promising new material April 29th, 2016

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

Chemists use DNA to build the world's tiniest thermometer April 27th, 2016

Bruker Introduces Dimension FastScan Pro Industrial AFM: Providing Nanometer-Resolution at High Scan Rates for up to 300-mm Samples April 26th, 2016

Nanobiotechnology

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic