Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Feeling the Force of Cancer

Using ARTIDIS to feel the tissue structure of a tumor biopsy by a nanometer-sized atomic force microscope tip (Image: Martin Oeggerli)
Using ARTIDIS to feel the tissue structure of a tumor biopsy by a nanometer-sized atomic force microscope tip

(Image: Martin Oeggerli)

Abstract:
Breast cancer is the most common form of cancer in women with 5500 patients being diagnosed with the disease in Switzerland each year. Despite major scientific advancements in our understanding of the disease, breast cancer diagnostics remains slow and subjective. Here, the real danger lies in the lack of knowing whether metastasis, the spread of cancer, has already occurred. Nevertheless, important clues may be hidden in how metastasis is linked to specific structural alterations in both cancer cells and the surrounding extracellular matrix. This forms the motivation behind ARTIDIS ("Automated and Reliable Tissue Diagnostics"), which was conceived by Dr. med. Marko Loparic, Dr. Marija Plodinec and Prof. Roderick Lim to measure the local nanomechanical properties of tissue biopsies.

Feeling the Force of Cancer

Basel, Switzerland | Posted on October 23rd, 2012

"Fingerprinting" breast tumors

At the heart of ARTIDIS lies an ultra-sharp atomic force microscope tip of several nanometers in size that is used as a local mechanical probe to "feel" the cells and extracellular structures within a tumor biopsy. In this way, a nanomechanical "fingerprint" of the tissue is obtained by systematically acquiring tens of thousands of force measurements over an entire biopsy. Subsequent analysis of over one hundred patient biopsies could confirm that the fingerprint of malignant breast tumors is markedly different as compared to healthy tissue and benign tumors. This was validated by histological analyses carried out by clinicians at the University Hospital Basel, which showed a complete agreement with ARTIDIS. Moreover, the same nanomechanical fingerprints were found in animal studies initiated at the Friedrich Miescher Institute.

Plodinec, first author of the study, explains: "This unique fingerprint reflects the heterogeneous make-up of malignant tissue whereas healthy tissue and benign tumors are more homogenous." Strikingly, malignant tissue also featured a marked predominance of "soft" regions that is a characteristic of cancer cells and the altered microenvironment at the tumor core. The significance of these findings lies in reconciling the notion that soft cancer cells can more easily deform and "squeeze" through their surroundings. Indeed, the presence of the same type of "soft" phenotype in secondary lung tumors of mice reinforces the close correlation between the physical properties of cancer cells and their metastatic potential.

ARTIDIS in the clinics

"Resolving such basic scientific aspects of cancer further underscores the use of nanomechanical fingerprints as quantitative markers for cancer diagnostics with the potential to prognose metastasis.", states Loparic, who is project manager for ARTIDIS. On an important practical note, a complete biopsy analysis by ARTIDIS currently takes four hours in comparison to conventional diagnostics, which can take one week. Based on the potential societal impact of ARTIDIS to revolutionize breast cancer diagnostics, Lim's team and the Swiss company Nanosurf AG have now been awarded about 1.2 million Swiss francs by the Commission for Technology and Innovation (CTI) to further develop ARTIDIS into a state-of-the-art device for disease diagnostics with further applications in nanomedicine.

Over the next two years, Lim and colleagues will engage and work closely with clinicians to develop ARTIDIS into an easy-to-use "push-button" application to fingerprint diseases across a wide range of biological tissues. As a historical starting point, the first ARTIDIS demo-lab has already been established at the University Hospital Eye Clinic to collect data on retinal diseases with the goal of improving treatment strategies.

####

For more information, please click here

Contacts:
Thomas Schnyder

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

MTU engineers examine lithium battery defects January 28th, 2020

Extraction of lithium from its largest source, i.e. seawater, by nanostructured membranes January 27th, 2020

SUNY Poly Professor Partners with Leading Institutions on NSF Award for Quantum Information Science Research: SUNY Poly Research Builds Upon Recent Quantum-related Research Initiatives and Workshops January 27th, 2020

What if the Universe has no end? The Big Bang is widely accepted as being the beginning of everything we see around us, but other theories that are gathering support among scientists are suggesting otherwise January 25th, 2020

Imaging

Nanotubes may give the world better batteries: Rice U. scientists' method quenches lithium metal dendrites in batteries that charge faster, last longer January 16th, 2020

Color superlensing to assist in surpassing diffraction barrier: A paper by Kazan Federal University's Sergey Kharintsev appeared in Optics Letters January 3rd, 2020

A quantum breakthrough brings a technique from astronomy to the nano-scale: Multi-messenger approach allows scientists to probe electronic and magnetic materials at ultra-small length scales January 3rd, 2020

Bedside Analysis and Pathology Screening System to Be Demonstrated at CES 2020: CEA-Leti Will Demonstrate Next-Generation Technology that Enables Bedside Diagnosis of Disease at One-Tenth the Cost of Bulky Optical Microscopes December 20th, 2019

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2020 First Quarter Results January 24th, 2020

International Summit on Nanomedicine & Nanotechnology January 24th, 2020

How to keep boron inside cells during radiotherapy: a simple novel approach to cancer treatment January 24th, 2020

Nanomaterial fabric destroys nerve agents in battlefield-relevant conditions: Metal-organic framework-based composites donít need liquid water to work January 14th, 2020

Discoveries

Extraction of lithium from its largest source, i.e. seawater, by nanostructured membranes January 27th, 2020

Quantum physics: On the way to quantum networks January 24th, 2020

Nano-thin flexible touchscreens could be printed like newspaper: New touch-responsive technology is 100 times thinner than existing touchscreen materials and so pliable it can be rolled up like a tube January 24th, 2020

Old Molecule, New Tricks: Chemistry professors develop an electrochemical method for extracting uranium, and potentially other metal ions, from solution January 24th, 2020

Announcements

MTU engineers examine lithium battery defects January 28th, 2020

Extraction of lithium from its largest source, i.e. seawater, by nanostructured membranes January 27th, 2020

SUNY Poly Professor Partners with Leading Institutions on NSF Award for Quantum Information Science Research: SUNY Poly Research Builds Upon Recent Quantum-related Research Initiatives and Workshops January 27th, 2020

American Chemical Society names Philip Proteau as new editor-in-chief of the Journal of Natural Products January 24th, 2020

Tools

Color superlensing to assist in surpassing diffraction barrier: A paper by Kazan Federal University's Sergey Kharintsev appeared in Optics Letters January 3rd, 2020

ORNL researchers advance performance benchmark for quantum computers January 3rd, 2020

A quantum breakthrough brings a technique from astronomy to the nano-scale: Multi-messenger approach allows scientists to probe electronic and magnetic materials at ultra-small length scales January 3rd, 2020

Onto Innovation to Present at the 22nd Annual Needham Growth Conference January 3rd, 2020

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project