Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Progress in Using Magnetic Fields to Target Tumors

Abstract:
Since the advent of cancer nanotechnology, researchers have sought to use magnetic fields to increase the concentration of drug-loaded iron oxide nanoparticles that reach a tumor. However, magnetic fields drop off quickly with distance, making it almost impossible to consider such an approach for tumors located more than a few centimeters from the skin. To solve what appears to be a fundamentally unsolvable problem, researchers at the Stanford University Center of Cancer Nanotechnology Excellence (Stanford CCNE) have taken a two-pronged approach, one that uses an external magnetic field and an implantable magnetizable mesh to create local magnetic fields strong enough to trap nanoparticles at a specific location.

Progress in Using Magnetic Fields to Target Tumors

Bethesda, MD | Posted on October 21st, 2012

Sanjiv Gambhir and Shan Wang led the research team that developed this new approach to magnetic targeting. The team reported its findings in the journal ACS Nano. Drs. Gambhir and Wang are the co-principal investigators of the Stanford CCNE.

To boost the strength of the magnetic field near a tumor, the investigators used a commercially available micromesh made of nickel. When implanted close to tumors growing in mice, the mesh developed strong magnetic field gradients when a permanent magnet was placed next to the animal. These gradients were sufficient to capture large numbers of biocompatible magnetic iron oxide nanoparticles that the researchers injected into the animals.

The idea driving this work is that such a mesh could be implanted near a tumor in a procedure that would be far less invasive than tumor-removing surgery. The patient could then be treated with magnetic nanoparticles carrying large doses of antitumor drug. Such a procedure could also be useful in cases where surgical tumor removal is not feasible.

In one set of experiments, the investigators dosed tumor-bearing animals with an iron oxide nanoparticle coated with a molecule known to block angiogenesis, the growth of new blood vessels that tumors require to grow and spread. While the nanoparticles alone caused tumors to shrink, when administered along with magnetic field trapping, the rate of tumor shrinkage increased dramatically. The investigators noted that effect of generating a localized magnetic field in the vicinity of the tumor was similar to that seen when they doubled the dose of anti-angiogenic nanoparticles without additional magnetization.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Fluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects.”

Related News Press

News and information

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

New TriboLab CMP Provides Cost-Effective Characterization of Chemical Mechanical Wafer Polishing Processes: Bruker Updates Industry-Standard CP-4 Platform for Most Flexible and Reliable Testing June 27th, 2017

Imaging

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Atomic imperfections move quantum communication network closer to reality June 25th, 2017

Research accelerates quest for quicker, longer-lasting electronics: UC Riverside-led research makes topological insulators magnetic well above room temperatures June 25th, 2017

U.S. Air Force Research Lab Taps IBM to Build Brain-Inspired AI Supercomputing System: Equal to 64 million neurons, new neurosynaptic supercomputing system will power complex AI tasks at unprecedented speed and energy efficiency June 23rd, 2017

Rice U. chemists create 3-D printed graphene foam June 22nd, 2017

Nanomedicine

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

Learning with light: New system allows optical “deep learning”: Neural networks could be implemented more quickly using new photonic technology June 12th, 2017

Mussels add muscle to biocompatible fibers: Rice University chemists develop hydrogel strings using compound found in sea creatures June 9th, 2017

Discoveries

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Atomic imperfections move quantum communication network closer to reality June 25th, 2017

Research accelerates quest for quicker, longer-lasting electronics: UC Riverside-led research makes topological insulators magnetic well above room temperatures June 25th, 2017

Announcements

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project