Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Progress in Using Magnetic Fields to Target Tumors

Abstract:
Since the advent of cancer nanotechnology, researchers have sought to use magnetic fields to increase the concentration of drug-loaded iron oxide nanoparticles that reach a tumor. However, magnetic fields drop off quickly with distance, making it almost impossible to consider such an approach for tumors located more than a few centimeters from the skin. To solve what appears to be a fundamentally unsolvable problem, researchers at the Stanford University Center of Cancer Nanotechnology Excellence (Stanford CCNE) have taken a two-pronged approach, one that uses an external magnetic field and an implantable magnetizable mesh to create local magnetic fields strong enough to trap nanoparticles at a specific location.

Progress in Using Magnetic Fields to Target Tumors

Bethesda, MD | Posted on October 21st, 2012

Sanjiv Gambhir and Shan Wang led the research team that developed this new approach to magnetic targeting. The team reported its findings in the journal ACS Nano. Drs. Gambhir and Wang are the co-principal investigators of the Stanford CCNE.

To boost the strength of the magnetic field near a tumor, the investigators used a commercially available micromesh made of nickel. When implanted close to tumors growing in mice, the mesh developed strong magnetic field gradients when a permanent magnet was placed next to the animal. These gradients were sufficient to capture large numbers of biocompatible magnetic iron oxide nanoparticles that the researchers injected into the animals.

The idea driving this work is that such a mesh could be implanted near a tumor in a procedure that would be far less invasive than tumor-removing surgery. The patient could then be treated with magnetic nanoparticles carrying large doses of antitumor drug. Such a procedure could also be useful in cases where surgical tumor removal is not feasible.

In one set of experiments, the investigators dosed tumor-bearing animals with an iron oxide nanoparticle coated with a molecule known to block angiogenesis, the growth of new blood vessels that tumors require to grow and spread. While the nanoparticles alone caused tumors to shrink, when administered along with magnetic field trapping, the rate of tumor shrinkage increased dramatically. The investigators noted that effect of generating a localized magnetic field in the vicinity of the tumor was similar to that seen when they doubled the dose of anti-angiogenic nanoparticles without additional magnetization.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Fluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects.”

Related News Press

News and information

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Imaging

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE