Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles Glow Through Thick Layer of Tissue: Novel, biocompatible nanoparticles glow through more than 3 centimeters of biological tissue, demonstrating the promise of nanotechnology in biomedical imaging

A transmission electron microscopy image of nanoparticles designed for deep-tissue imaging. Each particle consists of a core encased inside a square, calcium-fluoride shell. Photo credit: Zhipeng Li
A transmission electron microscopy image of nanoparticles designed for deep-tissue imaging. Each particle consists of a core encased inside a square, calcium-fluoride shell.

Photo credit: Zhipeng Li

Abstract:
An international research team has created unique photoluminescent nanoparticles that shine clearly through more than 3 centimeters of biological tissue -- a depth that makes them a promising tool for deep-tissue optical bioimaging.

Nanoparticles Glow Through Thick Layer of Tissue: Novel, biocompatible nanoparticles glow through more than 3 centimeters of biological tissue, demonstrating the promise of nanotechnology in biomedical imaging

Buffalo, NY | Posted on September 28th, 2012

Though optical imaging is a robust and inexpensive technique commonly used in biomedical applications, current technologies lack the ability to look deep into tissue, the researchers said.

This creates a demand for the development of new approaches that provide high-resolution, high-contrast optical bioimaging that doctors and scientists could use to identify tumors or other anomalies deep beneath the skin.

The newly created nanoparticles consist of a nanocrystalline core containing thulium, sodium, ytterbium and fluorine, all encased inside a square, calcium-fluoride shell.

The particles are special for several reasons. First, they absorb and emit near-infrared light, with the emitted light having a much shorter wavelength than the absorbed light. This is different from how molecules in biological tissues absorb and emit light, which means that scientists can use the particles to obtain deeper, higher-contrast imaging than traditional fluorescence-based techniques.

Second, the material for the nanoparticles' shell --calcium fluoride -- is a substance found in bone and tooth mineral. This makes the particles compatible with human biology, reducing the risk of adverse effects. The shell is also found to significantly increase the photoluminescence efficiency.

To emit light, the particles employ a process called near-infrared-to-near-infrared up-conversion, or "NIR-to-NIR." Through this process, the particles absorb pairs of photons and combine these into single, higher-energy photons that are then emitted.

One reason NIR-to-NIR is ideal for optical imaging is that the particles absorb and emit light in the near-infrared region of the electromagnetic spectrum, which helps reduce background interference. This region of the spectrum is known as the "window of optical transparency" for biological tissue, since the biological tissue absorbs and scatters light the least in this range.

The scientists tested the particles in experiments that included imaging them injected in mice, and imaging a capsule full of the particles through a slice of pork more than 3 centimeters thick. In each case, the researchers were able to obtain vibrant, high-contrast images of the particles shining through tissue.

The results of the study appeared online on Aug. 28 in the ACS Nano journal. The international collaboration included researchers from the University at Buffalo and other institutions in the U.S., China, South Korea and Sweden. It was co-led by Paras N. Prasad, a SUNY Distinguished Professor and executive director of UB's Institute for Lasers, Photonics and Biophotonics (ILPB), and Gang Han, an assistant professor at University of Massachusetts Medical School.

"We expect that the unprecendented properties in the core/shell nanocrystals we designed will bridge numermous disconnections between in vitro and in vivo studies, and eventully lead to new discoveries in the fields of biology and medicine," said Han, expressing his excitement about the research findings.

Study co-author Tymish Y. Ohulchanskyy, a deputy director of ILPB, believes the 3-centimeter optical imaging depth is unprecedented for nanoparticles that provide such high-contrast visualization.

"Medical imaging is an emerging area, and optical imaging is an important technique in this area," said Ohulchanskyy. "Developing this new nanoplatform is a real step forward for deeper tissue optical bioimaging."

The paper's first authors were Guanying Chen, research assistant professor at ILPB and scientist at China's Harbin Institute of Technology and Sweden's Royal Institute of Technology and Jie Shen of the University of Massachusetts Medical School. Other institutions that contributed included Roswell Park Cancer Institute, the University of North Carolina at Chapel Hill and Korea University at Seoul.

The next step in the research is to explore ways of targeting the nanoparticles to cancer cells and other biological targets that could be imaged. Chen, Shen and Ohulchanskyy said the hope is for the nanoparticles to become a platform for multimodal bioimaging.

####

For more information, please click here

Contacts:
Charlotte Hsu

716-645-4655

Copyright © University at Buffalo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Imaging

New non-invasive method can detect Alzheimer's disease early: MRI probe technology shows brain toxins in living animals for first time December 22nd, 2014

News and information

New non-invasive method can detect Alzheimer's disease early: MRI probe technology shows brain toxins in living animals for first time December 22nd, 2014

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Nanomedicine

New non-invasive method can detect Alzheimer's disease early: MRI probe technology shows brain toxins in living animals for first time December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Discoveries

New non-invasive method can detect Alzheimer's disease early: MRI probe technology shows brain toxins in living animals for first time December 22nd, 2014

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Announcements

New non-invasive method can detect Alzheimer's disease early: MRI probe technology shows brain toxins in living animals for first time December 22nd, 2014

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Tools

New non-invasive method can detect Alzheimer's disease early: MRI probe technology shows brain toxins in living animals for first time December 22nd, 2014

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE