Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > A New Playground for Particle Design

Researchers from the University of Jena (Germany) designed glycopolymeric materials with tailored properties to independently study the parameters that impact cellular uptake.
Researchers from the University of Jena (Germany) designed glycopolymeric materials with tailored properties to independently study the parameters that impact cellular uptake.

Abstract:
Synthetic polymers offer the possibility to introduce biologically active moieties and to design tailor-made macromolecules with well-defined architectures and properties. The design of glycopolymeric materials with tailored properties has become a very important topic of interest in current chemistry, biology, and medicine.

A New Playground for Particle Design

Germany | Posted on August 10th, 2012

The main reason behind this significance lies within their structure. A glycopolymer, by definition, consists of a synthetic polymeric backbone with covalently-linked, pendant carbohydrate moieties. The backbone may be composed of various monomeric units, in different arrangements. As a consequence, it provides the possibility to adjust the physical properties, such as water solubility of the final material.

The second building block of a glycopolymer consists of pendant sugar moieties which act as ligands for a broad spectrum of protein receptors that play an important role in different cell-surface interactions. Therefore, the structure of synthetic glycopolymers allows the precise modification of their material and biological features for special biomedical purposes.

Now, the research group around Ulrich Schubert (University of Jena) have demonstrated that poly(pentafluorostyrene)-based glycopolymers also possess the above-mentioned properties. By the introduction of hydrophobic polystyrene block into the backbone they can modify the water solubility of the system and obtain amphiphilic glycopolymers. These materials do not dissolve in aqueous environments. Under appropriate conditions they form nanoparticles with carbohydrates on the surface. By the introduction of glucose or galactose the recognition and uptake of these polymers by liver cancer cells is modified.

Fluorescence microscopy and flow cytometry show that nanoparticles are taken up by these cells to a higher degree than respective water soluble polymers, and that internalization of galactosylated materials is enhanced. These glycopolymers can find a multitude of potential applications in, for example, liver tumor-targeted chemotherapy, imaging, and as extracellular matrices for hepatocytes.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper on Wiley Online Library:

Related News Press

News and information

The International Space Elevator Consortium (ISEC) is proud to announce the 2014 Space Elevator Conference! This annual event will be held at the Museum of Flight in Seattle, Washington from Friday, August 22nd through Sunday, August 24th August 19th, 2014

KaSAM-2014 International Conference (September 7-10, 2014, Kathmandu, Nepal) August 19th, 2014

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Chemistry

Production of Toxic Ion Nanosorbents with High Sorption Capacity in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Could hemp nanosheets topple graphene for making the ideal supercapacitor? August 12th, 2014

Iranians Find Novel Method for Processing Highly Pure Ceramic Nanoparticles August 12th, 2014

Nanomedicine

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

Discoveries

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Сalculations with Nanoscale Smart Particles August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Announcements

Сalculations with Nanoscale Smart Particles August 19th, 2014

Life on Mars? Implications of a newly discovered mineral-rich structure August 19th, 2014

Harris & Harris Group Letter to Shareholders on Website August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Nanobiotechnology

Сalculations with Nanoscale Smart Particles August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE