Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > A New Playground for Particle Design

Researchers from the University of Jena (Germany) designed glycopolymeric materials with tailored properties to independently study the parameters that impact cellular uptake.
Researchers from the University of Jena (Germany) designed glycopolymeric materials with tailored properties to independently study the parameters that impact cellular uptake.

Abstract:
Synthetic polymers offer the possibility to introduce biologically active moieties and to design tailor-made macromolecules with well-defined architectures and properties. The design of glycopolymeric materials with tailored properties has become a very important topic of interest in current chemistry, biology, and medicine.

A New Playground for Particle Design

Germany | Posted on August 10th, 2012

The main reason behind this significance lies within their structure. A glycopolymer, by definition, consists of a synthetic polymeric backbone with covalently-linked, pendant carbohydrate moieties. The backbone may be composed of various monomeric units, in different arrangements. As a consequence, it provides the possibility to adjust the physical properties, such as water solubility of the final material.

The second building block of a glycopolymer consists of pendant sugar moieties which act as ligands for a broad spectrum of protein receptors that play an important role in different cell-surface interactions. Therefore, the structure of synthetic glycopolymers allows the precise modification of their material and biological features for special biomedical purposes.

Now, the research group around Ulrich Schubert (University of Jena) have demonstrated that poly(pentafluorostyrene)-based glycopolymers also possess the above-mentioned properties. By the introduction of hydrophobic polystyrene block into the backbone they can modify the water solubility of the system and obtain amphiphilic glycopolymers. These materials do not dissolve in aqueous environments. Under appropriate conditions they form nanoparticles with carbohydrates on the surface. By the introduction of glucose or galactose the recognition and uptake of these polymers by liver cancer cells is modified.

Fluorescence microscopy and flow cytometry show that nanoparticles are taken up by these cells to a higher degree than respective water soluble polymers, and that internalization of galactosylated materials is enhanced. These glycopolymers can find a multitude of potential applications in, for example, liver tumor-targeted chemotherapy, imaging, and as extracellular matrices for hepatocytes.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper on Wiley Online Library:

Related News Press

News and information

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Chemistry

Chains of nanogold – forged with atomic precision September 23rd, 2016

Carbon-coated iron catalyst structure could lead to more-active fuel cells September 15th, 2016

Researchers build world's largest database of crystal surfaces and shapes September 14th, 2016

On-surface chemistry leads to novel products: On-surface chemical Reactions can lead to novel chemical compounds not yet synthesized by solution chemistry. September 13th, 2016

Nanomedicine

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Discoveries

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

UNAM develops successful nano edible coating which increases life food September 27th, 2016

Announcements

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Nanobiotechnology

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic