Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > NIST focuses on testing standards to support lab on a chip commercialization

This is a microfluidic lab on a chip device sitting on a polystyrene dish. Stainless steel needles inserted into the apparatus serve as access points for fluids into small channels within it.

Credit: Gregory A. Cooksey/NIST
This is a microfluidic lab on a chip device sitting on a polystyrene dish. Stainless steel needles inserted into the apparatus serve as access points for fluids into small channels within it.

Credit: Gregory A. Cooksey/NIST

Abstract:
Lab on a chip (LOC) devices—microchip-size systems that can prepare and analyze tiny fluid samples with volumes ranging from a few microliters (millionth of a liter) to sub-nanoliters (less than a billionth of a liter)—are envisioned to one day revolutionize how laboratory tasks such as diagnosing diseases and investigating forensic evidence are performed. However, a recent paper* from the National Institute of Standards and Technology (NIST) argues that before LOC technology can be fully commercialized, testing standards need to be developed and implemented.

NIST focuses on testing standards to support lab on a chip commercialization

Gaithersburg, MD | Posted on August 9th, 2012

"A testing standard," explains NIST physical scientist and paper author Samuel Stavis, "defines the procedures used to determine if a lab on a chip device, and the materials from which it is made, conform to specifications." Standardized testing and measurement methods, Stavis writes, will enable MEMS (microelectromechanical systems) LOC manufacturers at all stages of production—from processing of raw materials to final rollout of products—to accurately determine important physical characteristics of LOC devices such as dimensions, electrical surface properties, and fluid flow rates and temperatures.

To make his case for testing standards, Stavis focuses on autofluorescence, the background fluorescent glow of an LOC device that can interfere with the analysis of a sample. Stavis states that multiple factors must be considered in the development of a testing standard for autofluorescence, including: the materials used in the device, the measurement methods used to test the device and how the measurements are interpreted. "All of these factors must be rigorously controlled for, or appropriately excluded from, a meaningful measurement of autofluorescence," Stavis writes.

Quality control during LOC device manufacturing, Stavis says, may require different tests of autofluorescence throughout the process. "There may be one measure of autofluorescence from the block of plastic that is the base material for a chip, another once the block has been fashioned into the substrate in which the functional components are embedded, and yet another as the final device is completed," Stavis says. "To manufacture lab on a chip devices with reliably low autofluorescence, accurate measurements may be needed at each stage."

Stavis also emphasizes that it is important not to confuse testing standards with product standards, and to understand how the former facilitates the latter. "A product standard specifies the technical requirements for a lab on a chip device to be rated as top quality," he says. "A testing standard is needed to measure those specifications, as well as to make fair comparisons between competing products."

* Stavis, S.M. A glowing future for lab on a chip testing standards. Lab on a Chip (2012), DOI: 10.1039/c2lc40511c

####

For more information, please click here

Contacts:
Michael E. Newman

301-975-3025

Copyright © National Institute of Standards and Technology (NIST)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

National Conference on Nanomaterials, (NCN-2017) April 21st, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

Microfluidics/Nanofluidics

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Laboratories

NIST physicists show ion pairs perform enhanced 'spooky action' March 30th, 2017

A big leap toward tinier lines: Self-assembly technique could lead to long-awaited, simple method for making smaller microchip patterns March 27th, 2017

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Researchers develop groundbreaking process for creating ultra-selective separation membranes: Discovery could greatly improve energy-efficiency of separation and purification processes in the chemical and petrochemical industries March 15th, 2017

Discovery in new material raises questions about theoretical models of superconductivity March 13th, 2017

Lab-on-a-chip

Researchers make flexible glass for tiny medical devices: Glass can bend over and over again on a nanoscale March 27th, 2017

Govt.-Legislation/Regulation/Funding/Policy

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Better living through pressure: Functional nanomaterials made easy April 19th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Emergency Use Authorization for Gene-RADAR® Zika Virus Test: FDA Authorization for the Gene-RADAR® Zika Virus Test on the XPRIZE-Winning Gene-RADAR® Platform April 14th, 2017

Chip Technology

'Neuron-reading' nanowires could accelerate development of drugs for neurological diseases April 12th, 2017

Nanometrics to Announce First Quarter Financial Results on May 2, 2017 April 11th, 2017

AIM Photonics Presents Cutting-Edge Integrated Photonics Technology Developments to Packed House at OFC 2017, the Optical Networking and Communication Conference & Exhibition April 11th, 2017

Photonics breakthough paving the way for improved wireless communication systems: The work could bolster the wireless revolution underway with efficiencies several orders of magnitude April 5th, 2017

Announcements

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

National Conference on Nanomaterials, (NCN-2017) April 21st, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project