Nanotechnology Now |
Home > Press > Antibacterial Nanoparticles Prove More Efficient than Gentamicin in Fighting Infections
 |
Abstract:
A multidisciplinary and multinational research group consisted of researchers from the University of Tehran, Iran, University of Mons, Belgium, University of Groningen and University of Twente, the Netherlands, carefully investigated the antibacterial behavior of magnetic iron oxide nanoparticles and demonstrated their efficacy as biocompatible antibacterial agents.
Antibacterial Nanoparticles Prove More Efficient than Gentamicin in Fighting Infections
Tehran, Iran | Posted on August 7th, 2012In order to overcome the shortcomings of the commonly prescribed antibiotics in the treatment of infections caused by implanted biomaterials, the researchers devised an external magnetic field to guide the mentioned nanoparticles towards the grown bacterial colonies through a targeted drug delivery approach. By doing so, a multiple-fold higher antibacterial activity, compared with gentamicin, was achieved.
"As the initial part of our research, we carried out a feasibility study on the use of SPOINs (superparamagnetic iron oxide nanoparticles) as bactericide agents. The idea was triggered by the fact that most of metal nanoparticles exhibit antibacterial characteristics. Although their applicability is hindered by their potential toxicities, SPOINs are found to kill only the bacteria and being harmless to human body cells," Dr. Shahriar Sharifi, member of the research group, explained.
"Bearing the special magnetic properties of the SPOINs in mind, we tried to direct these nanoparticles to the locations of the bacterial colonies by exerting an external magnetic field. In this way, we came up with considerably increased and deeper penetration of the nanoparticles into the formed biofilms. These diffused SPOINs later generate reactive oxygen species (ROS), thanks to their nanometric dimensions as small as 5 nm, which damage the bacterial cell walls resulting in their death." Dr. Sharifi said, explaining about the mechanism of antibacterial activity of the SPIONs.
The results of this research work have been published in detail in Acta Biomaterialia.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
| Related News Press |
News and information
JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion techniques May 21st, 2013
International survey supports need for built-in water protection on smartphones and tablets May 21st, 2013
Nanomedicine
How Gold Nanoparticles Can Help Fight Ovarian Cancer May 21st, 2013
Nanoparticle Delivers Large Protein Complex to Cancer Cell Nucleus May 20th, 2013
Elsevier Business Intelligence (EBI) to Host 'IN3 Medical Device 360 Boston,' June 24-26, 2013 May 20th, 2013
Discoveries
How Gold Nanoparticles Can Help Fight Ovarian Cancer May 21st, 2013
Study Led by George Washington University Professor Provides Better Understanding of Water’s Freezing Behavior at Nanoscale May 21st, 2013
Announcements
JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion techniques May 21st, 2013
International survey supports need for built-in water protection on smartphones and tablets May 21st, 2013
Nanobiotechnology
Researchers Perform Fastest Measurements Ever Made of Ion Channel Proteins May 20th, 2013
Research partnerships
Kinks and curves at the nanoscale: New research shows 'perfect twin boundaries' are not so perfect May 20th, 2013
Advancements and developments of solid-state nanopores sensors May 16th, 2013
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
University Technology Transfer & Patents
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||
abbigliamento uomo
Computer Accessories
| © Copyright 1999-2013 7th Wave, Inc. All Rights Reserved | PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE |