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|Mr Van Ortega, a graduate student in Professor Goss' lab operating the Malvern Instruments Zetasizer Nano DLS system.|
Researchers at the University of Alberta, Canada, working as part of a major Canadian initiative to investigate the aquatic and environmental aspects of nanoparticles, are using the Zetasizer Nano from Malvern Instruments to characterize nanoparticle behavior in biological and aqueous matrices. Size is known to affect nanoparticle toxicity and toxicology and the technique of dynamic light scattering (DLS) provides the average size behavior in solution. As implemented in the Zetasizer Nano, it delivers information for physical characterization in terms of charge and solubility.
Professor Greg Goss is Director of the Office of Environmental Nano Safety (OENS) in the Department of Biological Sciences at the University of Alberta. "Dynamic light scattering is now recognized as a basic characterization technique in this area of work and the regulators are familiar with the measurement, its results and limitations. In the past we've used TEM but this works better in conjunction with DLS since we can now study size in solution in a way that is simple to use and with only minimal need for sample preparation," he said. "DLS is the only technique on campus that can provide size information in solution, without drying the samples."
Professor Goss and his team have previously used earlier models of DLS instruments but find that, compared with other systems, the Zetasizer Nano delivers information that is not only much easier to understand and is more consistent, but enables significantly more data interpretation: "We can now study interactions of proteins in ways that previously were not feasible," he confirmed.
The Zetasizer Nano is used by this research group to study the interactions of particles such as silver, titanium, silica and polymer coated quantum dots. Elsewhere in the department it also plays a role in the analysis of other systems, micelles and polymers for example.
Malvern's Zetasizer range combines particle size, zeta potential and molecular weight analysis for particles and molecules from below a nanometer in size to several microns. The system measures size using dynamic light scattering, zeta potential and electrophoretic mobility using electrophoretic light scattering, and molecular weight using static light scattering.
For more information about the research interests of Professor Goss and his team please visit www.biology.ualberta.ca/faculty/greg_goss
For details of Malvern's Zetasizer family go to www.malvern.com/zetasizer
Malvern, Malvern Instruments and Zetasizer Nano are registered trademarks of Malvern Instruments Ltd
About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical identification. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.
Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.
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