Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > JPK reports on the research in the Marseille INSERM/CNRS laboratories where the NanoWizard AFM system is being used for cell studies

Dr Pierre-Henri Puech (inset) and his JPK NanoWizard® AFM system (INSERM/CNRS)
Dr Pierre-Henri Puech (inset) and his JPK NanoWizard® AFM system (INSERM/CNRS)

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of the NanoWizard® AFM system at the INSERM/CNRS Laboratories in Marseille, France.

JPK reports on the research in the Marseille INSERM/CNRS laboratories where the NanoWizard AFM system is being used for cell studies

Berlin, Germany | Posted on July 10th, 2012

The Laboratory of Cell Adhesion and Inflammation is located in Marseille as part of the INSERM/CNRS complex on the Luminy campus. It is a multidisciplinary research unit comprised of investigators with backgrounds in physics, biology and medicine. Their aim is to adapt physical concepts and methodologies to the understanding of cell function, notably cell adhesion in the immune system, with the goal of applying the results of this fundamental research to relevant clinical problems.

Dr Pierre-Henri Puech is an INSERM staff scientist in the group of Pierre Bongrand working on forces at the molecular and cellular level to determine what are the physical cues that cells integrate in feeling and understanding their environment. He works on describing, among other topics, what are the physical parameters that a T cell measures when scanning an antigen presenting cell (APC). This is to determine whether the cell or the organism is facing an external perturbation such as a virus invasion or modification due to deterioration of cells, such as via cancerous transformation. Since this recognition goes through the interaction between the T cell receptor (TCR) and a peptide presenting protein (pMHC) at the surface of the APC, is it the duration of the bond between the pMHC and TCR (or off rate), its strength, its on-rate or the interaction with the cytoskeleton that is the determining mechanisms of the read-out. Using fluorescence microscopy coupled to AFM, the question "how does this signal, mechanical or adhesive / recognition get integrated by the cell in order to understand and take a decision to change its function (for example either becoming activated or not)" can be addressed using phosphorylation or calcium reporting dyes. Such approaches are extended to cell cancer studies and to parasite / host interactions.

This is predominantly fundamental research work where Dr Puech is seeking to understand how cells physically understand the world they are living in and how they "play" in this world - how they function: either in a positive role (e.g. T cells) or a negative one (cancerous cells or parasites).

Before adding AFM to his techniques, Dr Puech used various micropipette-based techniques such as Biomembrane Force Probe, fluorescence microscopy, interference microscopy and simple microfluidic devices. In talking about working with JPK and their NanoWizard AFM system, Dr Puech says "It is simple and robust to use. It is designed for biological applications. It is particularly user friendly so that a biology student with no knowledge in instrumentation can learn it in less than a month. The AFM can be easily coupled to other techniques such as optics. I like the software because of it being Linux-based with open access. It comes with user-friendly force curve and image processing software, and also you can program the system using an easy to learn language (Jython) to follow non-standard procedures. Lastly, I think that JPK's technical support staff is very competent. I like their nice, efficient and rapid approach to helping me and my users."

For more details about JPK's specialist products and applications for the bio and nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com or see more on Facebook: www.jpk.com/facebook.

####

About JPK Instruments (JPK)
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK's success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For more information, please click here

Contacts:
JPK Instruments AG
Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
www.jpk.com


Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
United Kingdom
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com

Copyright © JPK Instruments (JPK)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

Laboratories

HP Supercomputer at NREL Garners Top Honor October 19th, 2014

ORNL research reveals unique capabilities of 3-D printing October 15th, 2014

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

Imaging

New Grand ARM Transmission Electron Microscope Offers Highest Commercially-Available Atomic Resolution of 63 Picometers October 17th, 2014

Nanotronics Imaging Releases nSPEC® 3D, Powerful Microscope That Captures 3D Images at Nanoscale, in Lightning Speed: Company Unveils Design at American Chemical Society 2014 International Elastomer Conference October 14th, 2014

Nanomedicine

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

European Commission opens the gate towards the implementation of Nanomedicine Translation Hub October 16th, 2014

Tuning light to kill deep cancer tumors: Nanoparticles developed at UMass Medical School advance potential clinical application for photodynamic therapy October 15th, 2014

Announcements

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Removal of Limitations of Composites at Superheat Temperatures October 20th, 2014

Tools

New Grand ARM Transmission Electron Microscope Offers Highest Commercially-Available Atomic Resolution of 63 Picometers October 17th, 2014

Nanodevices for clinical diagnostic with potential for the international market: The development is based on optical principles and provides precision and allows saving vital time for the patient October 15th, 2014

Nanotronics Imaging Releases nSPEC® 3D, Powerful Microscope That Captures 3D Images at Nanoscale, in Lightning Speed: Company Unveils Design at American Chemical Society 2014 International Elastomer Conference October 14th, 2014

Unique catalysts for hydrogen fuel cells synthesized in ordinary kitchen microwave oven October 14th, 2014

New-Contracts/Sales/Customers

Dyesol Signs Letter of Intent with Tata Steel October 13th, 2014

HZO Teams With Deutsche Telekom to Unveil the Waterproof Tolino Vision 2 eReader: The New HZO Protected eReader Ushers in a New Era of Waterproof Electronics, Providing a Seamless User Experience Without the Risk of Using Port Doors and Mechanical Seals October 10th, 2014

Fullerex: Talga Resources Joins INSCX™ Exchange September 4th, 2014

Global Energy Systems Signs Master Sales Agreement with China Aviation Supplies Group September 4th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE