Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > JPK reports on the research in the Marseille INSERM/CNRS laboratories where the NanoWizard AFM system is being used for cell studies

Dr Pierre-Henri Puech (inset) and his JPK NanoWizard® AFM system (INSERM/CNRS)
Dr Pierre-Henri Puech (inset) and his JPK NanoWizard® AFM system (INSERM/CNRS)

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of the NanoWizard® AFM system at the INSERM/CNRS Laboratories in Marseille, France.

JPK reports on the research in the Marseille INSERM/CNRS laboratories where the NanoWizard AFM system is being used for cell studies

Berlin, Germany | Posted on July 10th, 2012

The Laboratory of Cell Adhesion and Inflammation is located in Marseille as part of the INSERM/CNRS complex on the Luminy campus. It is a multidisciplinary research unit comprised of investigators with backgrounds in physics, biology and medicine. Their aim is to adapt physical concepts and methodologies to the understanding of cell function, notably cell adhesion in the immune system, with the goal of applying the results of this fundamental research to relevant clinical problems.

Dr Pierre-Henri Puech is an INSERM staff scientist in the group of Pierre Bongrand working on forces at the molecular and cellular level to determine what are the physical cues that cells integrate in feeling and understanding their environment. He works on describing, among other topics, what are the physical parameters that a T cell measures when scanning an antigen presenting cell (APC). This is to determine whether the cell or the organism is facing an external perturbation such as a virus invasion or modification due to deterioration of cells, such as via cancerous transformation. Since this recognition goes through the interaction between the T cell receptor (TCR) and a peptide presenting protein (pMHC) at the surface of the APC, is it the duration of the bond between the pMHC and TCR (or off rate), its strength, its on-rate or the interaction with the cytoskeleton that is the determining mechanisms of the read-out. Using fluorescence microscopy coupled to AFM, the question "how does this signal, mechanical or adhesive / recognition get integrated by the cell in order to understand and take a decision to change its function (for example either becoming activated or not)" can be addressed using phosphorylation or calcium reporting dyes. Such approaches are extended to cell cancer studies and to parasite / host interactions.

This is predominantly fundamental research work where Dr Puech is seeking to understand how cells physically understand the world they are living in and how they "play" in this world - how they function: either in a positive role (e.g. T cells) or a negative one (cancerous cells or parasites).

Before adding AFM to his techniques, Dr Puech used various micropipette-based techniques such as Biomembrane Force Probe, fluorescence microscopy, interference microscopy and simple microfluidic devices. In talking about working with JPK and their NanoWizard AFM system, Dr Puech says "It is simple and robust to use. It is designed for biological applications. It is particularly user friendly so that a biology student with no knowledge in instrumentation can learn it in less than a month. The AFM can be easily coupled to other techniques such as optics. I like the software because of it being Linux-based with open access. It comes with user-friendly force curve and image processing software, and also you can program the system using an easy to learn language (Jython) to follow non-standard procedures. Lastly, I think that JPK's technical support staff is very competent. I like their nice, efficient and rapid approach to helping me and my users."

For more details about JPK's specialist products and applications for the bio and nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com or see more on Facebook: www.jpk.com/facebook.

####

About JPK Instruments (JPK)
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK's success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For more information, please click here

Contacts:
JPK Instruments AG
Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
www.jpk.com


Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
United Kingdom
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com

Copyright © JPK Instruments (JPK)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Laboratories

New pathway to valleytronics January 27th, 2015

Nanoshuttle wear and tear: It's the mileage, not the age January 26th, 2015

News and information

New pathway to valleytronics January 27th, 2015

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

Entanglement on a chip: Breakthrough promises secure communications and faster computers January 27th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Promising use of nanodiamonds in delivering cancer drug to kill cancer stem cells: NUS study shows that delivery of Epirubicin by nanodiamonds resulted in a normally lethal dosage of Epirubicin becoming a safe and effective dosage for treatment of liver cancer January 26th, 2015

Imaging

Visualizing interacting electrons in a molecule: Scientists at Aalto University and the University of Zurich have succeeded in directly imaging how electrons interact within a single molecule January 26th, 2015

Graphene brings quantum effects to electronic circuits January 22nd, 2015

Nanomedicine

Stomach acid-powered micromotors get their first test in a living animal January 27th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Promising use of nanodiamonds in delivering cancer drug to kill cancer stem cells: NUS study shows that delivery of Epirubicin by nanodiamonds resulted in a normally lethal dosage of Epirubicin becoming a safe and effective dosage for treatment of liver cancer January 26th, 2015

Teijin to Participate in Nano Tech 2015 January 22nd, 2015

Announcements

New pathway to valleytronics January 27th, 2015

Entanglement on a chip: Breakthrough promises secure communications and faster computers January 27th, 2015

Detection of Heavy Metals in Samples with Naked Eye January 26th, 2015

Engineering self-assembling amyloid fibers January 26th, 2015

Tools

Visualizing interacting electrons in a molecule: Scientists at Aalto University and the University of Zurich have succeeded in directly imaging how electrons interact within a single molecule January 26th, 2015

Graphene brings quantum effects to electronic circuits January 22nd, 2015

EnvisioNano: An image contest hosted by the National Nanotechnology Initiative (NNI) January 22nd, 2015

New Molecular Beam Epitaxy deposition equipment at the ICN2 January 22nd, 2015

New-Contracts/Sales/Customers

DELMIC reports on applications of their SPARC technology at the Chalmers University of Technology in Gothenburg, Sweden December 16th, 2014

Industrial Nanotech, Inc. Expands Government and Defense Projects December 10th, 2014

Iran Exports Nanodrugs to Syria November 24th, 2014

Tesla NanoCoatings Increasing Use of SouthWest NanoTechnologies Carbon Nanotubes (CNTs) for its Infrastructure Coatings and Paints: High Quality SMW™ Specialty Multi-wall Carbon Nanotubes Incorporated into Teslan®-brand coatings used by Transportation, Oil and Gas Companies November 19th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE