Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Building Molecular 'Cages' to Fight Disease

Abstract:
Researchers at the University of Washington in Seattle and the University of California, Los Angeles (UCLA) have developed a computational approach to designing specialized proteins that assemble themselves to form nanoparticle cages that can be used to deliver drugs to tumors and other sites of disease. Published in the journal Science, this research could be utilized to create nanoparticle cages from any number of different proteins, with potential applications across the fields of medicine and molecular biology.

Building Molecular 'Cages' to Fight Disease

Bethesda, MD | Posted on July 2nd, 2012

UCLA investigator David Yeates led this study. He and his colleagues used computer models to identify two proteins that could be combined to form perfectly-shaped three-dimensional puzzle pieces. Twelve of these specialized pieces fit together to create a molecular cage a mere fraction of the size of a virus.

The specifically designed proteins intermesh to form a hollow lattice that could act as a vessel for drug delivery. In principle, it would be possible to attach a recognition sequence for cancer cells on the outside of the cage together with a chemotherapeutic agent. As currently designed, the assembled protein cages are porous enough that a drug placed inside would likely leak out during the delivery process. The investigators are now conducting computer modeling studies to design a new molecular cage with an interior that will be better sealed.

In a second paper that was also published in Science, Dr. Yeates and University of Washington colleague David Baker describe how they created similarly designed molecular cages using multiple copies of the same protein as building blocks. The scientists control the shape of the cage by computing the sequence of amino acids necessary to link the proteins together at the correct angles. This alternative method represents a more versatile approach in theory because it requires only one type of protein to form a structure, Dr. Yeates said.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View paper 1 abstract - "Structure of a 16-nm cage designed by using protein oligomers."

View paper 2 abstract - "Computational design of self-assembling protein nanomaterials with atomic level accuracy."

Related News Press

News and information

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Promising Ferroelectric Materials Suffer From Unexpected Electric Polarizations: Brookhaven Lab scientists find surprising locked charge polarizations that impede performance in next-gen materials that could otherwise revolutionize data-driven devices August 18th, 2014

Novel chip-based platform could simplify measurements of single molecules: A nanopore-gated optofluidic chip combines electrical and optical measurements of single molecules onto a single platform August 14th, 2014

Self Assembly

Nanocubes Get in a Twist : Competing forces coax nanocubes into helical structures August 11th, 2014

Self-assembly of gold nanoparticles into small clusters August 4th, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Berkeley Lab researchers create nanoparticle thin films that self-assemble in 1 minute June 9th, 2014

Nanomedicine

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

Discoveries

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Announcements

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE