- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
|Familiar capsules of medicine taken by mouth could have a counterpart in minute capsules that enable production of medicine inside the body|
Scientists are reporting an advance toward treating disease with minute capsules containing not drugs — but the DNA and other biological machinery for making the drug. In an article in ACS' journal Nano Letters, they describe engineering micro- and nano-sized capsules that contain the genetically coded instructions, plus the read-out gear and assembly line for protein synthesis that can be switched on with an external signal.
Daniel Anderson and colleagues explain that development of nanoscale production units for protein-based drugs in the human body may provide a new approach for treating disease. These production units could be turned on when needed, producing medicines that cannot be taken orally or are toxic and would harm other parts of the body. Until now, researchers have only done this with live bacteria that were designed to make proteins at disease sites. But unlike bacterial systems, artificial ones are modular, and it is easier to modify them. That's why Anderson's group developed an artificial, remotely activated nanoparticle system containing DNA and the other "parts" necessary to make proteins, which are the workhorses of the human cell and are often used as drugs.
They describe the nanoscale production units, which are tiny spheres encapsulating protein-making machinery like that found in living cells. The resulting nanoparticles produced active proteins on demand when the researchers shined a laser light on them. The nanoparticles even worked when they were injected into mice, which are stand-ins for humans in the laboratory, producing proteins when a laser was shone onto the animals. This innovation "may find utility in the localized delivery of therapeutics," say the researchers.
The authors acknowledge funding from the Misrock Foundation, the Life Sciences Research Foundation, the National Cancer Institute, the National Institutes of Health and the Marie D. & Pierre Casimir-Lambert Fund.
About American Chemical Society (ACS)
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.
To automatically receive news releases from the American Chemical Society, contact
For more information, please click here
Daniel G. Anderson, Ph.D.
David H. Koch Institute for Integrative Cancer Research
Department of Chemical Engineering
Harvard MIT Division of Health Science and Technology
Massachusetts Institute of Technology
Cambridge, Mass. 02139
Copyright © American Chemical Society (ACS)If you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
FEI and University of Liverpool Announce QEMSCAN Research Initiative: University of Liverpool will utilize FEI’s QEMSCAN technology to gain a better insight into oil and gas reserves & potentially change the approach to evaluating them June 22nd, 2016
French Research Team Helps Extend MRI Detection of Diseases & Lower Health-Care Costs: CEA, INSERM and G2ELab Brings Grenoble Region’s Expertise In Advanced Medicine & Magnetism Applications to H2020 IDentIFY Project June 21st, 2016