Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Synthetic blood vessels could lead to breakthroughs in tissue engineering

Provided/Stroock lab
Reconstruction of fluorescence confocal micrographs of a microvascular network with endothelial-cell lined channels (red) and perivascular cells (green) in collagen. After two weeks in culture, the presence of the tissue cells drove sprouting of new vessels from the original endothelium.
Provided/Stroock lab

Reconstruction of fluorescence confocal micrographs of a microvascular network with endothelial-cell lined channels (red) and perivascular cells (green) in collagen. After two weeks in culture, the presence of the tissue cells drove sprouting of new vessels from the original endothelium.

Abstract:
Human tissue, be it in the heart, brain or bones, can't function without a vascular system -- the intricate network of vessels that circulate life-sustaining blood and nutrients. And it's notoriously hard to introduce vascularization into synthetic tissue for use in regenerative medicine, like tissue replacement surgery.

Synthetic blood vessels could lead to breakthroughs in tissue engineering

Ithaca, NY | Posted on May 29th, 2012

Enter Cornell engineers, taking an engineer's approach to making synthetic blood vessels. They've designed tiny, 3-D microchannels in a soft biomaterial and injected human umbilical vein endothelial cells into the channels. They embedded tissue cells from the brain into the surrounding gel and watched the interactions between the "vessels" and cells, which commonly surround microvessels in the body.

Signals from these tissue cells led to new blood vessels sprouting from the originals -- a living network of blood vessels engineered completely in vitro.

The results, which could lead to new techniques in regenerative medicine and better drug delivery strategies, are from the lab of Abe Stroock, associate professor of chemical and biomolecular engineering and member of the Kavli Institute at Cornell for Nanoscale Science.

The work is published in Proceedings of the National Academy of Sciences May 28.

Such live, in-vitro microvessels could be a step toward developing human tissues to study biological processes in the lab for implantation into the body during surgery.

"The hope is we can start with something this simple, and the cells will then grow into the capillary structures and higher order vessel structures required for a fully deployed vascular system," Stroock said.

The researchers also experimented with mimicking diseases like cancer or thrombosis in the vessels by infecting them with certain compounds or proteins known to promote vessel growth or create an inflammatory response.

In a collaboration with the Jose Lopez lab at the Puget Sound Blood Center, the researchers showed that healthy vessels proved to be a good, non-sticky interface for transporting blood smoothly, even around corner vessels, which are traditionally where blockages due to disease occur. The researchers found that when the vessels were treated with an inflammatory compound, they became thrombotic -- similar to when real vessels become inflamed.

To further inform their study, the researchers collaborated with Claudia Fischbach-Teschl, associate professor of biomedical engineering, who studies how tumors grow. A signaling protein called VEGF, when added to the microvasculature, led to development of new blood vessels sprouting from the originals -- a hallmark of how tumors grow.

"One of the evil geniuses of tumors is knowing how to grow new vasculatures," Stroock explained.

He said he was interested in developmental vascular biology from an engineer's perspective because of the hypothesis that physical flow informs the development of microvessels even from an embryonic stage. In order to understand how a simple grid of tubes in a placenta transforms into the geometry of the microvasculature in humans, it is important to understand how the physical environment influences these initial vessels, he said.

"The mechanics of the flow play a central role in defining what the network will be," Stroock said.

The paper's first author is Ying Zheng, a former postdoctoral associate who is now at the University of Washington in Seattle. The work at Cornell was supported by the National Institutes of Health through the Cornell Center on the Microenvironment and Metastasis, Human Frontiers in Science Programme, the New York State Division of Science, Technology and Innovation, and the Arnold and Mabel Beckman Foundation.

####

For more information, please click here

Contacts:
Anne Ju

(607) 255-9735

Media Contact:
John Carberry
(607) 255-5353

Copyright © Cornell University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Graphene may be key to leap in supercapacitor performance August 20th, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Nanomedicine

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

Discoveries

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Announcements

Graphene may be key to leap in supercapacitor performance August 20th, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE