Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanomedicines on their way through the body

Abstract:
Which pathways do nanomedicines take after they have been swallowed? Scientists find a recirculation pathway of polymeric micelles using multimodal nonlinear optical microscopy.

Nanomedicines on their way through the body

Exeter, UK | Posted on May 25th, 2012

Advances in pharmaceutical nanotechnology have yielded ever increasingly sophisticated nanoparticles for medicine delivery. When administered via oral, intravenous, ocular and transcutaneous delivery routes, these nanoparticles can elicit enhanced drug performance. One such recently developed nanoparticle is Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ), a chitosan-based polymeric micelle which can be used to encapsulate drugs and enhance their oral absorption and their intravenous activity by up to one order of magnitude. In spite of its great potential, the mechanisms by which GCPQ micelles - or other nanoparticle-based delivery systems - interact with organs at the cellular scale are not yet clear. However, full knowledge of these mechanisms is a prerequisite for a rational design optimizing their performance.

Natalie Laura Garrett an a team of scientist from the University of Exeter and the UCL School of Pharmacy in London (UK) used multimodal nonlinear optical microscopy to investigate these mechanisms using deuterated GCPQ delivered orally to mice.

They combined coherent anti-Stokes Raman scattering (CARS) microscopy, second harmonic generation (SHG) and two photon fluorescence (TPF) microscopy as a multi-modal label-free method. CARS microscopy has many advantages over conventional imaging including: up to several hundred micron depth penetration into biological tissue; intrinsic optical sectioning and high spatial resolution; label-free chemically specific contrast. When combined with CARS microscopy, TPF and SHG allow detailed three-dimensional visualisation of nanoparticles pinpointed with sub-cellular precision against a complex biological background.

The multi-modal method was used to image three of the most important organs for oral drug delivery: the liver, the intestine and the gall bladder. By doing so, they demonstrated for the first time that orally administered chitosan nanoparticles follow a recirculation pathway from the gastrointestinal tract via enterocytes in the villi, pass into the blood stream and are transported to the hepatocytes and hepatocellular spaces of the liver and then to the gall bladder, before being re-released into the gut together with bile. Such recirculation may also improve drug absorption. (Text by K. Maedefessel-Herrmann)

N.L. Garret et al.; J. Biophotonics 5, 458-568 (2012); DOI 10.1002/jbio. 201200006

####

For more information, please click here

Contacts:
Regina Hagen
Journal Publishing Manager | Editorial Physics Department
Wiley-VCH Verlag GmbH & Co. KGaA
Rotherstr. 21, 10245 Berlin, Germany
Fon: +49 (0) 30/ 47 03 13 21
Fax: +49 (0) 30/ 47 03 13 99
E-Mail:

Copyright © Wiley-VCH Verlag GmbH & Co. KGaA

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Free access to the PDF of the article is available here:

Related News Press

News and information

Researchers engineer improvements of technology used in digital memory November 24th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Cooling with the coldest matter in the world November 24th, 2014

Imaging

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

NRL Scientists Discover Novel Metamaterial Properties within Hexagonal Boron Nitride November 20th, 2014

Spectral Surface Mapping with Microscopic Resolution: CRAIC Technologies introduces Spectral Surface Mapping™ (S2M™) software November 18th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

Nanomedicine

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Iran Exports Nanodrugs to Syria November 24th, 2014

Discoveries

Researchers engineer improvements of technology used in digital memory November 24th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Announcements

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Cooling with the coldest matter in the world November 24th, 2014

Tools

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Nanometrics Announces Upcoming Investor Events November 19th, 2014

Spectral Surface Mapping with Microscopic Resolution: CRAIC Technologies introduces Spectral Surface Mapping™ (S2M™) software November 18th, 2014

Research partnerships

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

Novel Method Found for Connection of Metallic Alloys to Polymers November 23rd, 2014

New research project supports internationalisation in nano-research: Launch of new “Baltic Sea Network” November 22nd, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE