Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanomedicines on their way through the body

Abstract:
Which pathways do nanomedicines take after they have been swallowed? Scientists find a recirculation pathway of polymeric micelles using multimodal nonlinear optical microscopy.

Nanomedicines on their way through the body

Exeter, UK | Posted on May 25th, 2012

Advances in pharmaceutical nanotechnology have yielded ever increasingly sophisticated nanoparticles for medicine delivery. When administered via oral, intravenous, ocular and transcutaneous delivery routes, these nanoparticles can elicit enhanced drug performance. One such recently developed nanoparticle is Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ), a chitosan-based polymeric micelle which can be used to encapsulate drugs and enhance their oral absorption and their intravenous activity by up to one order of magnitude. In spite of its great potential, the mechanisms by which GCPQ micelles - or other nanoparticle-based delivery systems - interact with organs at the cellular scale are not yet clear. However, full knowledge of these mechanisms is a prerequisite for a rational design optimizing their performance.

Natalie Laura Garrett an a team of scientist from the University of Exeter and the UCL School of Pharmacy in London (UK) used multimodal nonlinear optical microscopy to investigate these mechanisms using deuterated GCPQ delivered orally to mice.

They combined coherent anti-Stokes Raman scattering (CARS) microscopy, second harmonic generation (SHG) and two photon fluorescence (TPF) microscopy as a multi-modal label-free method. CARS microscopy has many advantages over conventional imaging including: up to several hundred micron depth penetration into biological tissue; intrinsic optical sectioning and high spatial resolution; label-free chemically specific contrast. When combined with CARS microscopy, TPF and SHG allow detailed three-dimensional visualisation of nanoparticles pinpointed with sub-cellular precision against a complex biological background.

The multi-modal method was used to image three of the most important organs for oral drug delivery: the liver, the intestine and the gall bladder. By doing so, they demonstrated for the first time that orally administered chitosan nanoparticles follow a recirculation pathway from the gastrointestinal tract via enterocytes in the villi, pass into the blood stream and are transported to the hepatocytes and hepatocellular spaces of the liver and then to the gall bladder, before being re-released into the gut together with bile. Such recirculation may also improve drug absorption. (Text by K. Maedefessel-Herrmann)

N.L. Garret et al.; J. Biophotonics 5, 458-568 (2012); DOI 10.1002/jbio. 201200006

####

For more information, please click here

Contacts:
Regina Hagen
Journal Publishing Manager | Editorial Physics Department
Wiley-VCH Verlag GmbH & Co. KGaA
Rotherstr. 21, 10245 Berlin, Germany
Fon: +49 (0) 30/ 47 03 13 21
Fax: +49 (0) 30/ 47 03 13 99
E-Mail:

Copyright © Wiley-VCH Verlag GmbH & Co. KGaA

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Free access to the PDF of the article is available here:

Related News Press

News and information

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Pseudoparticles travel through photoactive material: KIT scientists measure important process in the conversion of light energy -- publication in Nature Communications April 24th, 2015

Imaging

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Nanomedicine

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Scientists Use Nanoscale Building Blocks and DNA 'Glue' to Shape 3D Superlattices: New approach to designing ordered composite materials for possible energy applications April 23rd, 2015

Discoveries

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Pseudoparticles travel through photoactive material: KIT scientists measure important process in the conversion of light energy -- publication in Nature Communications April 24th, 2015

Surface matters: Huge reduction of heat conduction observed in flat silicon channels April 23rd, 2015

Announcements

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Pseudoparticles travel through photoactive material: KIT scientists measure important process in the conversion of light energy -- publication in Nature Communications April 24th, 2015

Surface matters: Huge reduction of heat conduction observed in flat silicon channels April 23rd, 2015

Tools

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

Drexel materials scientists putting a new spin on computing memory April 22nd, 2015

Quantum 'paparazzi' film photons in the act of pairing up April 22nd, 2015

Research partnerships

Pseudoparticles travel through photoactive material: KIT scientists measure important process in the conversion of light energy -- publication in Nature Communications April 24th, 2015

Electron spin brings order to high entropy alloys April 23rd, 2015

Surface matters: Huge reduction of heat conduction observed in flat silicon channels April 23rd, 2015

Drexel materials scientists putting a new spin on computing memory April 22nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project