Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Purdue professor to speak before Congress about nanotechnology in brain treatment research

This diagram illustrates the concept behind a new type of "bioactive" coating for stents used to treat brain aneurisms, including those suffered by military personnel from head trauma due to bomb blasts. Portions of the stents - tubular structures made of a metallic mesh - will be designed using coatings to attract magnetized cells to repair blood vessels damaged in trauma. (Purdue University image/Jean Paul Allain)
This diagram illustrates the concept behind a new type of "bioactive" coating for stents used to treat brain aneurisms, including those suffered by military personnel from head trauma due to bomb blasts. Portions of the stents - tubular structures made of a metallic mesh - will be designed using coatings to attract magnetized cells to repair blood vessels damaged in trauma. (Purdue University image/Jean Paul Allain)

Abstract:
Researchers at Purdue University are working with the U.S. Army and neurosurgeons at the Walter Reed National Military Medical Center to create a new type of "bioactive" coating for stents used to treat brain aneurisms including those caused by head trauma from bomb blasts.

Purdue professor to speak before Congress about nanotechnology in brain treatment research

West Lafayette, IN | Posted on May 21st, 2012

"Stents coated with a bioactive coating might be inserted at the site of an aneurism to help heal the inside lining of the blood vessel," said Jean Paul Allain, an associate professor of nuclear engineering. "Aneurisms are saclike bulges in blood vessels caused by weakening of artery walls. We're talking about using a regenerative approach, attracting cells to reconstruct the arterial wall."

He will speak before Congress on Thursday (May 24) during the first Brain Mapping Day to discuss the promise of nanotechnology in treating brain injury and disease.

Purdue researchers are working with Col. Rocco Armonda, Dr. Teodoro Tigno and other neurosurgeons at Walter Reed National Military Medical Center in Bethesda, Md. Collaborations also are planned with research scientists from the University of Queensland in Australia, Universidad de Antioquía and Universidad de Los Andes, both in Colombia.

Portions of the stents - tubular structures made of a metallic mesh - will be designed using bioactive coatings to attract magnetized cells to repair blood vessels damaged in trauma.

The stent coatings are modified in a Purdue facility that uses beams of charged particles called ions to modify the stent coatings with a magnetic material. The ion beams also are used to create lifelike or "biomimetic" surface textures designed to promote cellular proliferation and repair damaged vessels, Allain said.

Findings will be detailed in an invited talk to be delivered by Allain during the Ninth Annual World Congress of SBMT on Brain, Spinal Cord Mapping and Image Guide Therapy on June 2-4 in Toronto.

Currently, aneurisms are treated either by performing brain surgery, opening the skull and clipping the sac, or by inserting a catheter through an artery into the brain and implanting a metallic coil into the balloon-like sac.

Both procedures risk major complications, including massive bleeding or the formation of potentially fatal blood clots.

"The survival rate is about 50/50 or worse, and those who do survive could be impaired," said Allain, who holds a courtesy appointment with materials engineering and is affiliated with the Birck Nanotechnology Center in Purdue's Discovery Park.

Cells needed to repair blood vessels are influenced by both the surface texture - features such as bumps and irregular shapes as tiny as 10 nanometers wide - as well as the surface chemistry of the stent materials.

"We are learning how to regulate cell proliferation and growth by tailoring both the function of surface chemistry and topology," Allain said. "There is correlation between surface chemistry and how cells send signals back and forth for proliferation. So the surface needs to be tailored to promote regenerative healing."

The facility being used to irradiate the stents - the Radiation Surface Science and Engineering Laboratory in Purdue's School of Nuclear Engineering - also is used for work aimed at developing linings for experimental nuclear fusion reactors for power generation.

Irradiating materials with the ion beams causes surface features to "self-organize" and also influences the surface chemistry, Allain said.

The stents are made of nonmagnetic materials, such as stainless steel and an alloy of nickel and titanium. Only a certain part of the stents is rendered magnetic to precisely direct the proliferation of cells to repair a blood vessel where it begins bulging to form the aneurism.

Researchers will study the stents using blood from pigs during the first phase in collaboration with the Walter Reed National Military Medical Center.

The stent coating's surface is "functionalized" so that it interacts properly with the blood-vessel tissue. Some of the cells are magnetic naturally, and "magnetic nanoparticles" would be injected into the bloodstream to speed tissue regeneration. Researchers also are aiming to engineer the stents so that they show up in medical imaging to reveal how the coatings hold up in the bloodstream.

The research is led by Allain and co-principal investigator Lisa Reece of the Birck Nanotechnology Center. This effort has spawned new collaborations with researchers around the world including those at Universidad de Antioquía, University of Queensland. The research also involves doctoral students Ravi Kempaiah and Emily Walker.

The work is funded with a three-year, $1.5 million grant from the U.S. Army.

####

For more information, please click here

Contacts:
Writer: Emil Venere
765-494-4709


Source:
Jean Paul Allain
765 496-9718

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) September 25th, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Govt.-Legislation/Regulation/Funding/Policy

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Nanomedicine

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) September 25th, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Discoveries

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Announcements

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) September 25th, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Military

Ultracold atoms used to verify 1963 prediction about 1D electrons: Rice University, University of Geneva study focuses on theory that's increasingly relevant to chipmakers September 5th, 2018

Neutrophil nanosponges soak up proteins that promote rheumatoid arthritis September 3rd, 2018

Virginia Tech researchers develop novel process to 3D print one of the strongest materials on Earth August 23rd, 2018

Biomimetic micro/nanoscale fiber reinforced composites August 10th, 2018

Events/Classes

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Nanobiotix: Update on Head and Neck Phase I/II Trial with NBTXR3 and Other program data presented at ImmunoRad 2018 September 20th, 2018

Arrowhead Pharmaceuticals to Present at Upcoming September 2018 Conferences August 31st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project