Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Purdue University researchers use nanoscale IR spectroscopy via AFM-IR to provide key insights into drug-polymer blends

Abstract:
Two new papers are going to press featuring the use of Anasys Instruments' nanoIR™ system by Professor Lynne S. Taylor's group in the Department of Industrial and Physical Pharmacy at Purdue University. In each study, miscibility of pharmaceutically relevant blends was examined and specific sub-micrometer-sized domains characterized using standard atomic force microscopy (AFM) and nanoscale Infrared spectroscopy (AFM-IR).

Purdue University researchers use nanoscale IR spectroscopy via AFM-IR to provide key insights into drug-polymer blends

Santa Barbara, CA | Posted on May 8th, 2012

The first of the two papers, entitled "Nanoscale Mid-Infrared Imaging of Phase Separation in a Drug-Polymer Blend" is being published in the June 2012 issue of the Journal of Pharmaceutical Sciences. The researchers at Purdue explored the applicability of nanoscale IR spectroscopy and imaging to analyze a partially miscible model pharmaceutical drug-polymer system consisting of felodipine and poly(acrylic acid) (PAA). By combining AFM topography imaging with AFM-IR chemical information obtained at a high spatial resolution, it was possible to interrogate both the structure and chemical composition of phases in the felodipine-PAA blends.

The second of the papers "Nanoscale Mid-Infrared Evaluation of the Miscibility Behavior of Blends of Dextran or Maltodextrin with Poly(vinylpyrrolidone)" has been accepted for publication in the Journal of Molecular Pharmaceuticals. In this study, the AFM topography data combined with AFM-IR chemical information provided structural insights into the formation of phase-separated systems. The size, shape, and distribution of the different domains formed and the dependence of these features on the molecular weights of the polymers was analyzed. AFM-IR analysis is an important complement to more traditional miscibility evaluation probes currently available in the field. According to Professor Taylor "being able to obtain infrared spectra at nanoscale spatial resolution is a dramatic development that should provide new insights into the microstructure of pharmaceutical formulations. This will enable us perform in-depth studies that enable relationships between microstructure, processing and product performance to be elucidated."

Reference 1: "Nanoscale Mid-Infrared Imaging of Phase Separation in a Drug-Polymer Blend", Bernard Van Eerdenbrugh, Micheal Lo, Kevin Kjoller, Curtis Marcott, and Lynne S. Taylor, Journal of Pharmaceutical Sciences, 101(6), 2066-2073, (2012).
Publication Date (Web): March 2, 2012 DOI: 10.1002/jps.23099

Reference 2: "Nanoscale Mid-Infrared Evaluation of the Miscibility Behavior of blends of Dextran or Maltodextrin with Poly(vinylpyrrolidone)", Bernard Van Eerdenbrugh, Micheal Lo, Kevin Kjoller, Curtis Marcott, and Lynne S. Taylor, Molecular Pharmaceutics, in press.
Publication Date (Web): April 8, 2012 DOI: 10.1021/mp300059z

####

About Anasys Instruments
Anasys Instruments is dedicated to delivering innovative products and solutions that analyze samples with spatially varying physical and chemical properties at the micro and nanoscale. Anasys Instruments introduced the nanoTA in 2006 which pioneered the field of nanoscale thermal property measurement. In 2010, Anasys Instruments proudly introduced the award-winning breakthrough nanoIR™ Platform which pioneered the field of nanoscale IR measurement.

For more information, please click here

Contacts:
Anasys contact:

Roshan Shetty
Anasys Instruments Corporation
121 Gray Avenue, Suite 100
Santa Barbara
CA 93101 USA
Tel: +1 (805) 730-3310

www.anasysinstruments.com
Media contact:

Jezz Leckenby
Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA, UK
Tel: +44 (0) 1799 521881
Mob: +44 (0) 7843 012997

www.talking-science.com

Copyright © Anasys Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Imaging

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

News and information

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Discoveries

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

Fraud-proof credit card possible because of quantum physics December 16th, 2014

Announcements

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Tools

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

Bruker Introduces BioScope Resolve High-Resolution BioAFM System: Featuring PeakForce Tapping for Quantitative Bio-Mechanical Property Mapping December 16th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE