Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New X-Ray Bionanoprobe Advances Life Science Research: instruments that can image whole, unsectioned cells in 3D, in their natural, hydrated state, and at a resolution significantly below 100 nm.”

Abstract:
Deployed last fall at the APS beam line operated by the Life Sciences Collaborative Access Team (LS-CAT), the Bionanoprobe is already enabling new, more cohesive imaging procedures. "We expect this unique capability to produce new insights into the behavior of nanoparticles within cells, in pharmacology and toxicology, environmental studies and other vital areas," says Dr. Keith Brister, LS-CAT Operations Manager.

New X-Ray Bionanoprobe Advances Life Science Research: instruments that can image whole, unsectioned cells in 3D, in their natural, hydrated state, and at a resolution significantly below 100 nm.”

Pleasanton, CA | Posted on April 24th, 2012

Unveiled in 2011, Xradia's Bionanoprobe enables imaging in four different modes: high resolution X-ray Fluorescence (XRF), transmission, spectroscopy, and tomography. The combination of these techniques provides information on elemental content, structure and chemical state, in 3D, over a wide range of length scales. Previously, to examine cells and other samples at progressively higher resolutions, researchers typically switched between multiple techniques such as magnetic resonance imaging (MRI), computed tomography (CT), visible light microscopy and electron microscopy, often using different samples and different preparation techniques for each one.

"Using one technique makes it possible to compare elements more precisely," says Dr. Woloschak. "Traditionally, looking at tissue under a regular microscope then moving to an electron microscope requires that we use different sections and preparation techniques, which can introduce artifacts and make it hard to compare and co-localize features. The best we could do is match as closely as possible; we couldn't look at the exact item under varying conditions."

The Bionanoprobe is also the first imaging solution to combine ultra-high resolution trace element mapping with cryogenic sample preservation and tomographic capabilities. Cryo preservation is essential to study cells and tissue in a state closely resembling that of being alive, while minimizing the effects of radiation damage that can distort the results. Tomography, or 3D imaging, is needed to exactly localize the features of interest inside the cell.

"The Bionanoprobe's cryogenic sample-handling system allows researchers to move the same cryogenically preserved sample from the X-ray nanoprobe to a transmission X-ray microscope, or potentially other cryo instruments," says Dr. Wenbing Yun, founder and CTO of Xradia, Inc. "Scientists look at tissue down to subcellular locations with one technique, which is virtually impossible otherwise."

####

About Xradia, Inc.
Xradia designs and manufactures microscopes for industrial and academic research applications. Xradia’s solutions offer unparalleled high contrast and high resolution imaging capabilities for a large range of sample sizes and shapes. The company’s heritage began in the synchrotron and extends to the laboratory. Xradia's two laboratory product families, the UltraXRM-L and VersaXRM™, together offer a multi-length scale solution delivering full volume 3D imaging with resolution down to 50 nm. Energy-tunable, ultra-high resolution 3D X-ray microscopes for synchrotron facilities include the UltraSPX™ and the UltraXRM-S.

About the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine

The Lurie Cancer Center is one of only 40 NCI-designated "Comprehensive" cancer centers in the nation and is a founding member of the National Comprehensive Cancer Network (NCCN), an alliance of 21 of the world's leading cancer centers dedicated to improving the quality and effectiveness of care.

About LS-CAT

The Life Sciences Collaborative Access Team (LS-CAT) is a consortium of eight institutions led by Northwestern University to provide state of the art synchrotron radiation instrumentation for biological experiments. LS-CAT researchers, along with several other biological facilities at the Advanced Photon Source at Argonne National Labs, lead the world in the area of macromolecular crystallography with substantial contributions to biology, genomics, and drug discovery. The collaboration between the APS, Xradia, and LS-CAT leverages the LS-CAT staff's expertise to provide new capabilities both to the LS-CAT members and to the general scientific community.

The eight institutional members of LS-CAT are Michigan State University, University of Michigan, Wayne State University, Van Andel Research Institution, University of Wisconsin at Madison, Vanderbilt University, University of Illinois, and Northwestern University. Additionally, researchers from other universities and companies regularly use the LS-CAT facilities.

About APS at Argonne National Laboratory

The Advanced Photon Source (APS) at the U.S. Department of Energy’s Argonne National Laboratory provides the United States’ brightest storage ring-generated X-ray beams for research in almost all scientific disciplines. These x-rays allow scientists to pursue new knowledge about the structure and function of materials in the center of the Earth and in outer space, and all points in between. The knowledge gained from this research can impact the evolution of combustion engines and microcircuits, aid in the development of new pharmaceuticals, and pioneer nanotechnologies whose scale is measured in billionths of a meter. These studies promise to have far-reaching impact on our technology, economy, health, and our fundamental knowledge of the materials that make up our world.

Xradia is a registered trademark and UltraXRM, VersaXRM, and UltraSPX are trademarks of Xradia, Inc.

For more information, please click here

Contacts:
Brenda Ropoulos
Phone: 1.510.414.6772
Fax: 925.730.4952

Copyright © Xradia, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Living computers: RNA circuits transform cells into nanodevices July 27th, 2017

Laboratories

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Studying Argon Gas Trapped in Two-Dimensional Array of Tiny "Cages": Understanding how individual atoms enter and exit the nanoporous frameworks could help scientists design new materials for gas separation and nuclear waste remediation July 17th, 2017

Imaging

Phenom-World Launches Phenom Pro and ProX Generation 5 SEMs at Microscopy & Microanalysis Conference USA: The excellent performance in a wide range of applications offers a serious alternative to floor model SEMs July 26th, 2017

The School of Materials at the University of Manchester utilise Deben’s mechanical stages to characterise structure and behaviour at the micro- and nano- scale July 25th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Govt.-Legislation/Regulation/Funding/Policy

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

Ultrathin device harvests electricity from human motion July 23rd, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Nanomedicine

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Discoveries

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Announcements

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Tools

Phenom-World Launches Phenom Pro and ProX Generation 5 SEMs at Microscopy & Microanalysis Conference USA: The excellent performance in a wide range of applications offers a serious alternative to floor model SEMs July 26th, 2017

The School of Materials at the University of Manchester utilise Deben’s mechanical stages to characterise structure and behaviour at the micro- and nano- scale July 25th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Coupling a nano-trumpet with a quantum dot enables precise position determination July 14th, 2017

Alliances/Trade associations/Partnerships/Distributorships

GLOBALFOUNDRIES and VeriSilicon To Enable Single-Chip Solution for Next-Gen IoT Networks: Integrated solution leverages GF’s 22FDX® technology to decrease power, area, and cost for NB-IoT and LTE-M applications July 14th, 2017

Advanced Nanomechanical Characterization Centre Open in India: Nanomechanics, Inc. announces the establishment of the joint technology development center in Hyderabad, India July 5th, 2017

U.S. Air Force Research Lab Taps IBM to Build Brain-Inspired AI Supercomputing System: Equal to 64 million neurons, new neurosynaptic supercomputing system will power complex AI tasks at unprecedented speed and energy efficiency June 23rd, 2017

Cambridge Nanotherm partners with Inabata for global sales and distribution June 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project