Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > New X-Ray Bionanoprobe Advances Life Science Research: instruments that can image whole, unsectioned cells in 3D, in their natural, hydrated state, and at a resolution significantly below 100 nm.”

Abstract:
Deployed last fall at the APS beam line operated by the Life Sciences Collaborative Access Team (LS-CAT), the Bionanoprobe is already enabling new, more cohesive imaging procedures. "We expect this unique capability to produce new insights into the behavior of nanoparticles within cells, in pharmacology and toxicology, environmental studies and other vital areas," says Dr. Keith Brister, LS-CAT Operations Manager.

New X-Ray Bionanoprobe Advances Life Science Research: instruments that can image whole, unsectioned cells in 3D, in their natural, hydrated state, and at a resolution significantly below 100 nm.”

Pleasanton, CA | Posted on April 24th, 2012

Unveiled in 2011, Xradia's Bionanoprobe enables imaging in four different modes: high resolution X-ray Fluorescence (XRF), transmission, spectroscopy, and tomography. The combination of these techniques provides information on elemental content, structure and chemical state, in 3D, over a wide range of length scales. Previously, to examine cells and other samples at progressively higher resolutions, researchers typically switched between multiple techniques such as magnetic resonance imaging (MRI), computed tomography (CT), visible light microscopy and electron microscopy, often using different samples and different preparation techniques for each one.

"Using one technique makes it possible to compare elements more precisely," says Dr. Woloschak. "Traditionally, looking at tissue under a regular microscope then moving to an electron microscope requires that we use different sections and preparation techniques, which can introduce artifacts and make it hard to compare and co-localize features. The best we could do is match as closely as possible; we couldn't look at the exact item under varying conditions."

The Bionanoprobe is also the first imaging solution to combine ultra-high resolution trace element mapping with cryogenic sample preservation and tomographic capabilities. Cryo preservation is essential to study cells and tissue in a state closely resembling that of being alive, while minimizing the effects of radiation damage that can distort the results. Tomography, or 3D imaging, is needed to exactly localize the features of interest inside the cell.

"The Bionanoprobe's cryogenic sample-handling system allows researchers to move the same cryogenically preserved sample from the X-ray nanoprobe to a transmission X-ray microscope, or potentially other cryo instruments," says Dr. Wenbing Yun, founder and CTO of Xradia, Inc. "Scientists look at tissue down to subcellular locations with one technique, which is virtually impossible otherwise."

####

About Xradia, Inc.
Xradia designs and manufactures microscopes for industrial and academic research applications. Xradia’s solutions offer unparalleled high contrast and high resolution imaging capabilities for a large range of sample sizes and shapes. The company’s heritage began in the synchrotron and extends to the laboratory. Xradia's two laboratory product families, the UltraXRM-L and VersaXRM™, together offer a multi-length scale solution delivering full volume 3D imaging with resolution down to 50 nm. Energy-tunable, ultra-high resolution 3D X-ray microscopes for synchrotron facilities include the UltraSPX™ and the UltraXRM-S.

About the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine

The Lurie Cancer Center is one of only 40 NCI-designated "Comprehensive" cancer centers in the nation and is a founding member of the National Comprehensive Cancer Network (NCCN), an alliance of 21 of the world's leading cancer centers dedicated to improving the quality and effectiveness of care.

About LS-CAT

The Life Sciences Collaborative Access Team (LS-CAT) is a consortium of eight institutions led by Northwestern University to provide state of the art synchrotron radiation instrumentation for biological experiments. LS-CAT researchers, along with several other biological facilities at the Advanced Photon Source at Argonne National Labs, lead the world in the area of macromolecular crystallography with substantial contributions to biology, genomics, and drug discovery. The collaboration between the APS, Xradia, and LS-CAT leverages the LS-CAT staff's expertise to provide new capabilities both to the LS-CAT members and to the general scientific community.

The eight institutional members of LS-CAT are Michigan State University, University of Michigan, Wayne State University, Van Andel Research Institution, University of Wisconsin at Madison, Vanderbilt University, University of Illinois, and Northwestern University. Additionally, researchers from other universities and companies regularly use the LS-CAT facilities.

About APS at Argonne National Laboratory

The Advanced Photon Source (APS) at the U.S. Department of Energy’s Argonne National Laboratory provides the United States’ brightest storage ring-generated X-ray beams for research in almost all scientific disciplines. These x-rays allow scientists to pursue new knowledge about the structure and function of materials in the center of the Earth and in outer space, and all points in between. The knowledge gained from this research can impact the evolution of combustion engines and microcircuits, aid in the development of new pharmaceuticals, and pioneer nanotechnologies whose scale is measured in billionths of a meter. These studies promise to have far-reaching impact on our technology, economy, health, and our fundamental knowledge of the materials that make up our world.

Xradia is a registered trademark and UltraXRM, VersaXRM, and UltraSPX are trademarks of Xradia, Inc.

For more information, please click here

Contacts:
Brenda Ropoulos
Phone: 1.510.414.6772
Fax: 925.730.4952

Copyright © Xradia, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

Conductive Inks: booming to $2.8 billion by 2024 April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

Imaging

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Laboratories

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

'Life Redesigned: The Emergence of Synthetic Biology' Lecture at Brookhaven Lab on Wednesday, April 30: Biomedical Engineer James Collins to Speak for BSA Distinguished Lecture Series April 16th, 2014

Relieving electric vehicle range anxiety with improved batteries: Lithium-sulfur batteries last longer with nanomaterial-packed cathode April 16th, 2014

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

Govt.-Legislation/Regulation/Funding/Policy

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds April 17th, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

Nanomedicine

Innovative strategy to facilitate organ repair April 18th, 2014

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds April 17th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Discoveries

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Thinnest feasible membrane produced April 17th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Announcements

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Tools

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Alliances/Partnerships/Distributorships

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Peer Reviewed and Approved for Science by the the Washington Academy of Sciences April 3rd, 2014

New JEOL-Nikon MiXcroscopy Correlative Imaging Solution March 27th, 2014

Quantum Dots Take Center Stage at Inaugural Event: QD Vision Co-Founder and CTO Dr. Seth Coe-Sullivan to Chair First Quantum Dots Forum, March 26, 2014, San Diego, CA March 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE