Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > University of Illinois at Urbana-Champaign Announces Licensing Agreement with Sigma-Aldrich to Provide Membrane Scaffold Proteins for Nanodisc Technology to the Research Community

Abstract:
Sigma-Aldrich Corporation (Nasdaq: SIAL) and the University of Illinois at Urbana-Champaign have entered into a licensing agreement through which Sigma-Aldrich will offer two widely-used membrane scaffold proteins used in Nanodisc technology, developed by Professor Stephen Sligar, Director of the School of Molecular and Cellular Biology.

University of Illinois at Urbana-Champaign Announces Licensing Agreement with Sigma-Aldrich to Provide Membrane Scaffold Proteins for Nanodisc Technology to the Research Community

Urbana, IL | Posted on April 20th, 2012

The Nanodisc technology is enabling life science researchers to elucidate the structure and function of critical membrane proteins in a way not previously possible," said Robert Gates, Market Segment Manager for Sigma-Aldrich. "The diversity of applications and the significance of the advancement each time a new protein is incorporated into a Nanodisc demonstrate the importance of having a universal tool for such a broad scope of fundamental research."

Nanodiscs are self-assembled systems that render soluble in aqueous media typically insoluble yet biologically and pharmacologically significant targets, including receptors, transporters, enzymes, and viral antigens. Nanodisc constructs provide a native-like bilayer environment and maintain a target's functional activity, providing a versatile tool in the study of membrane proteins such as GPCRs, cytochrome P450s, bacteriorhodopsins, coagulation factors, cholera toxins, and Tar receptors. Since their introduction, Nanodiscs have been used in a diverse set of applications such as kinetic studies, structural analysis, imaging measurements, binding assays, and drug discovery. In 2011 alone, more than 25 independent groups published papers based on Nanodisc technology.

Sigma-Aldrich will feature the membrane scaffold proteins MSP1D1 and MSP1E3D1 as part of its innovative Sigma Life Science product portfolio. MSP's utilize the amphipathic properties found in Apolipoprotein A-1 to provide a multi-helical scaffold for incorporation of a range of target protein sizes. More information on these products is available at sigma-aldrich.com.

"We are proud to partner with Sigma-Aldrich Corporation to provide the membrane scaffold proteins that underpin the broadly applicable Nanodisc system," said Lesley Millar, Director of the Office of Technology Management at the University of Illinois at Urbana-Champaign. "We believe this alliance will further extend the impact of Nanodiscs in basic research as well as diagnostic and therapeutic developments."

Professor Sligar is also the I.C. Gunsalus Professor in the Department of Biochemistry and was recently named to the American Chemical Society's list of the fifty most prolific writers in the journal Biochemistry. He has won numerous awards, and is a Fellow of the Biophysical Society and the AAAS.

####

About University of Illinois at Urbana-Champaign
The University of Illinois at Urbana-Champaign is a world-class research institution boasting a respected faculty, high national rankings, and state-of-the art facilities. The University’s accomplishments include 22 Nobel Laureates among its faculty and alumni and such revolutionary innovations as the Web browser, new plant varieties and even the discovery of a third form of life. For more information about the Office of Technology Management at the University, please visit www.otm.illinois.edu.

About Sigma-Aldrich

Sigma-Aldrich is a leading Life Science and High Technology company whose biochemical, organic chemical products, kits and services are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical, diagnostics and high technology manufacturing. Sigma-Aldrich customers include more than 1.3 million scientists and technologists in life science companies, university and government institutions, hospitals and industry. The Company operates in 40 countries and has nearly 9,000 employees whose objective is to provide excellent service worldwide. Sigma-Aldrich is committed to accelerating customer success through innovation and leadership in Life Science and High Technology. For more information about Sigma-Aldrich, please visit its website at www.sigma-aldrich.com.

For more information, please click here

Contacts:
University of Illinois at Urbana-Champaign Office of Technology Management
Nicole Nair
Senior Marketing Coordinator
217-244-5011

Copyright © Business Wire

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Nanomedicine

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Copper will replace toxic palladium and expensive platinum in the synthesis of medications: The effectiveness of copper nanoparticles as a catalyst has been proven December 5th, 2017

Announcements

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Patents/IP/Tech Transfer/Licensing

Chinese market opens up for Carbodeon nanodiamonds: Carbodeon granted Chinese Patent for Nanodiamond-containing Thermoplastic Thermal Compounds December 4th, 2017

Picosun’s ALD nanolaminates improve lifetime and reliability of electronic circuit boards October 24th, 2017

Novel 'converter' heralds breakthrough in ultra-fast data processing at nanoscale: Invention bagged four patents and could potentially make microprocessor chips work 1,000 times faster October 20th, 2017

Nanoparticles limit damage in spinal cord injury: Injection after an injury reduces inflammation and scarring September 6th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project