Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Duke University uses Nanoparticle Tracking Analysis to characterize "nanoconstructs" for biomedical applications

Professor Tuan Vo-Dinh discusses results from his NanoSight NS500
with Dr Hsiangkuo Yuan from his research group.
Professor Tuan Vo-Dinh discusses results from his NanoSight NS500 with Dr Hsiangkuo Yuan from his research group.

Abstract:
NanoSight, leading manufacturers of unique nanoparticle characterization technology, reports on the work of Professor Tuan Vo-Dinh's group at Duke University where they apply Nanoparticle Tracking Analysis (NTA) to characterize metal nanoparticle construct materials for use in biosensing, imaging and cancer therapy.

Duke University uses Nanoparticle Tracking Analysis to characterize "nanoconstructs" for biomedical applications

Salisbury, UK | Posted on April 19th, 2012

The Vo-Dinh Lab is a part of the Departments of Biomedical Engineering and Chemistry of Duke University. The Vo-Dinh Lab is also a part of the Fitzpatrick Institute for Photonics, of which Professor Vo-Dinh is the director.

The main research goal of the group is to develop advanced techniques and methods to protect the environment (environmental sensors) and improve human health (medical diagnostics and therapy). As a part of these research goals, Dr Hsiangkuo Yuan and other members of Professor Vo-Dinh's group design and fabricate metal nanoparticle constructs such as gold nanostar platforms. These are characterized with UV-VIS, TEM, Raman microscope, fluorometers and other techniques. However, to design nanoconstructs for in vivo applications, the particle size needs to be in the range from 10 to 100 nm for lower clearance from the kidney and reticuloendothelial system (RES). It is important that the construct is in the right size range and is physiologically stable (non-aggregated) for biomedical applications in, for example, optical imaging or nanodrug delivery where it is also critical that the nanoparticle dose administered can be determined. To compare plasmonic properties, i.e. the enhanced electromagnetic properties of nanoparticles, they need to determine the effect of different sizes and to understand in detail the profile of the particle size distribution of similar concentrations which can be obtained using NanoSight's NTA system.

Prior to NTA, the group mostly used TEM to look at particle shape and measure particle size. The surface coating or the aggregation state cannot be easily investigated using just TEM. NanoSight provides a significant complementary role on providing hydrodynamic size distribution and zeta potential. Moreover, because NanoSight gives the concentration information, it allows them to normalize their comparison by individual particle counting which was quite difficult to obtain previously.

Commenting on the benefits of using the NanoSight alongside TEM (for size) and atomic absorption spectroscopy (for mass), Professor Vo-Dinh said the ability to make characterization particle by particle provides complementary information to the ensemble characterization (e.g. DLS). The group have published nanoconstruct data, specifically gold nanostars, in the journal, Nanotechnology, with another paper currently in press, Nanomedicine. They report the determination of particle hydrodynamic size distribution, zeta potential and concentration using NTA.

To find out about the company and to learn more about particle characterization using NanoSight's unique nanoparticle tracking analysis solutions, visit www.nanosight.com and register to receive the next issue of NanoTrail, the company's electronic newsletter.

####

About NanoSight
NanoSight delivers the world's most versatile and proven multi-parameter nanoparticle analysis in a single instrument.

NanoSight's "Nanoparticle Tracking Analysis" (NTA) detects and visualizes populations of nanoparticles in liquids down to 10 nm, dependent on material, and measures the size of each particle from direct observations of diffusion. Additionally, NanoSight measures concentration and a fluorescence mode differentiates suitably-labelled particles within complex background suspensions. Zeta potential measurements assess the surface charge on particles. NTA's particle-by-particle methodology goes beyond traditional light scattering and other ensemble techniques in providing high-resolution particle size distributions and validates data with information-rich video files of the particles moving under Brownian motion.

NanoSight's simultaneous multiparameter characterization matches the demands of complex biological systems, hence its wide application in development of drug delivery systems, of viral vaccines, and in nanotoxicology. This real-time data gives insight into the kinetics of protein aggregation and other time-dependent phenomena in a qualitative and quantitative manner. NanoSight has a growing role in biodiagnostics, being proven in detection and speciation of nanovesicles (exosomes) and microvesicles.

NanoSight has installed more than 450 systems worldwide with users including BASF, GlaxoSmithKline, Merck, Novartis, Pfizer, Proctor and Gamble, Roche and Unilever together with the most eminent universities and research institutes. NanoSight's technology is validated by 400+ third party papers citing NanoSight results, consolidating NanoSight's leadership position in nanoparticle characterization. For more information, visit www.nanosight.com

For more information, please click here

Contacts:
NanoSight Limited
Minton Park
London Road
Amesbury SP4 7RT UK
T +44(0)1980 676060
F +44(0)1980 624703


Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA UK
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com

Copyright © NanoSight

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Imaging

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

News and information

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Nanomedicine

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Sensors

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

Researchers create practical and versatile microscopic optomechanical device: Trapping light and mechanical waves within a tiny bullseye, design could enable more sensitive motion detection January 11th, 2017

STMicroelectronics Peps Up Booming Social-Fitness Scene with Smart Motion Sensors for Better Accuracy, Longer Battery Life, and Faster Time to Market January 2nd, 2017

Announcements

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Tools

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Distinguishing truth under the surface: electrostatic or mechanic December 31st, 2016

Nanomechanics Inc. Continues Growth in Revenue and Market Penetration: Leading nanoindentation company reports continued growth in revenues and distribution channels on national and international scales December 27th, 2016

New-Contracts/Sales/Customers

Cetim Facility Receives Bruker Contour CMM Dimensional Analysis System: New Optical Coordinate Measurement Technology Enables High-Precision 3D Scanning November 16th, 2016

Industrial Nanotech, Inc. Announces Plans to Spin Off New Product Line to Major Paint Compan November 9th, 2016

Leti Provides New Low-noise Image Technology to French SME PYXALIS; Will Be Demonstrated at Vision 2016 in Stuttgart November 3rd, 2016

DryWired's Liquid Nanotint to be the first nano-insulation in a Federal building: 250,000 federal buildings, most with uninsulated glass October 12th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project