Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Are silver nanoparticles harmful?

Abstract:
Silver nanoparticles cause more damage to testicular cells than titanium dioxide nanoparticles, according to a recent study by the Norwegian Institute of Public Health. However, the use of both types may affect testicular cells with possible consequences for fertility.

Are silver nanoparticles harmful?

Oslo, Norway | Posted on March 14th, 2012

Commonly used

Nanotechnology is increasingly used in consumer products, medicines and building products. The potential risks of using engineered nanoparticles need to be monitored so that the industry can develop products that are safe for humans and nature.

Previous research has shown that nanoparticles can cross both the blood-brain barrier and blood-testes barrier in mice and rats, and are taken up by cells. This study aimed to see if silver and titanium dioxide nanoparticles had any effect on human and mice testicular cells.

The researchers found that silver nanoparticles had a toxic effect on cells, suppressing cellular growth and multiplication and causing cell death depending on concentrations and duration of exposure. The effect was weaker for titanium dioxide nanoparticles, although both types did cause cell type-specific DNA damage, with possible implications on reproduction as well as human and environmental health.

"It seems that the type of nanoparticle, and not the size alone, may be the limiting factor" says Nana Asare, primary author of the study published in Toxicology.

Further studies using in vivo models are needed to study the impact of nanoparticles on reproductive health.
About the study

The researchers used cells from a human testicular carcinoma cell line and testicular cells from two strains of mice, one of which is genetically modified to serve as a representative model for human male reproductive toxicity. The cells were exposed to titanium dioxide nanoparticles (21nm) and two different sizes of silver nanoparticles (20 nm and 200nm) over different concentrations and time periods. Both sizes of silver nanoparticles inhibited normal cell function and caused more cell death than the titanium dioxide nanoparticles. In particular, the 200 nm silver particles caused a concentration-dependent increase in DNA damage in the human cells.
Reference

Asare N, Instanes C, Sandberg WJ, Refsnes M, Schwarze P, Kruszewski M, Brunborg G. Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells. Toxicology, 291: 65-72 (2012)

Nano facts

- Nanotechnology is technology on the atomic and molecular scale
- A nanometre (nm) is one billionth of a metre
- A nanoparticle is a particle with one or more external dimensions in the size range 1 nm - 100 nm
- The aspect ratio between a nanoparticle and a football is similar to that between a football and the Earth
- Nanotechnology is working on a scale of 100 nm (which corresponds approximately to the size of a virus) down to the size of atoms, about 0.1 nm
- Nano-scale materials and processes are present in nature, ranging from free molecules in gases and liquids to proteins and organic processes
- Some substances are produced unintentionally, such as welding dust and diesel particulates

####

For more information, please click here

Contacts:
Norwegian Institute of Public Health
PO Box 4404
Nydalen, N-0403 Oslo
Phone: +47 21077000
Fax: +47 22353605

Copyright © Norwegian Institute of Public Health

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells (PubMed):

Related News Press

News and information

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

INVECAS to Enable ASIC Designs for Tomorrows Intelligent Systems on GLOBALFOUNDRIES' FDX Technology: INVECAS to Collaborate with GLOBALFOUNDRIES to Provide IP and End-to-End ASIC Design Services on 22FDX and 12FDX Technologies September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Discoveries

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Nanosensors could help determine tumors ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Announcements

Harris & Harris Group Notes Announcements by Its Portfolio Companies During the Third Quarter of 2016 September 30th, 2016

INVECAS to Enable ASIC Designs for Tomorrows Intelligent Systems on GLOBALFOUNDRIES' FDX Technology: INVECAS to Collaborate with GLOBALFOUNDRIES to Provide IP and End-to-End ASIC Design Services on 22FDX and 12FDX Technologies September 30th, 2016

How to power up graphene implants without frying cells: New analysis finds way to safely conduct heat from graphene to biological tissues September 30th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Safety-Nanoparticles/Risk management

As You Sows Shareholder Inquiry on Nanomaterials Fought by Walgreens: Shareholder Proposal Addresses Recent Laboratory Tests Finding Harmful Nanomaterials in Walgreens Store Brand Infant Formula September 21st, 2016

Iran to hold intl. school on application of nanomaterials in medicine September 20th, 2016

Nano-Toxicity Testing at Regulatory Sciences Summit: In Vitro Tests Can Most Efficiently Assess Nanomaterial Toxicity September 6th, 2016

Mathematical nanotoxicoproteomics: Quantitative characterization of effects of multi-walled carbon nanotubes: This research article by Dr. Subhash Basak et al. will be published in Current Computer-Aided Drug Design, Volume 12, 2016 September 2nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic