Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researchers show influence of nanoparticles on nutrient absorption

This figure shows 50 nm carboxylated polystyrene nanoparticles (green) interacting with a cell culture model of the intestinal epithelium (red). Oral exposure to these particles was shown to affect iron transport.

Credit: Nature Nanotechnology
This figure shows 50 nm carboxylated polystyrene nanoparticles (green) interacting with a cell culture model of the intestinal epithelium (red). Oral exposure to these particles was shown to affect iron transport.

Credit: Nature Nanotechnology

Abstract:
Nanoparticles are everywhere. From cosmetics and clothes, to soda and snacks. But as versatile as they are, nanoparticles also have a downside, say researchers at Binghamton University and Cornell University in a recent paper published in the journal Nature Nanotechnology. These tiny particles, even in low doses, could have a big impact on our long-term health.

Researchers show influence of nanoparticles on nutrient absorption

Binghamton, NY | Posted on March 8th, 2012

According to lead author of the article, Gretchen Mahler, assistant professor of bioengineering at Binghamton University, much of the existing research on the safety of nanoparticles has been on the direct health effects. But what Mahler, Michael L. Shuler of Cornell University and a team of researchers really wanted to know was what happens when someone gets constant exposure in small doses - the kind you'd get if you were taken a drug or supplement that included nanoparticles in some form.

"We thought that the best way to measure the more subtle effects of this kind of intake was to monitor the reaction of intestinal cells," said Mahler. "And we did this in two ways - in vitro, through human intestinal-lining cells that we had cultured in the lab; and in vivo, through the intestinal linings of live chickens. Both sets of results pointed to the same thing - that exposure to nanoparticles influences the absorption of nutrients into the bloodstream."

The uptake of iron, an essential nutrient, was of particular interest due to the way it is absorbed and processed through the intestines. The way Mahler and the team tested this was to use polystyrene nanoparticles because of its easily traceable fluorescent properties.

"What we found was that for brief exposures, iron absorption dropped by about 50 percent," said Mahler. "But when we extended that period of time, absorption actually increased by about 200 percent. It was very clear - nanoparticles definitely affects iron uptake and transport."

While acute oral exposure caused disruptions to intestinal iron transport, chronic exposure caused a remodeling of the intestinal villi - the tiny, finger-like projections that are vital to the intestine's ability to absorb nutrients - making them larger and broader, thus allowing iron to enter the bloodstream much faster.

"The intestinal cells are a gateway that ingested nanoparticles must go through to get to the body," said Mahler. "We monitored iron absorption both in vivo and in vitro and found that the polystyrene nanoparticles affected the absorption process and caused a physiological response."

The next step for Mahler and the team is to take a look at whether similar disruptions in nutrient absorption could be possible in other inorganic elements such as calcium, copper and zinc. Also on the research agenda is the reaction of other nutrients such as fat-soluble vitamins A, D, E and K. And chickens and their intestines will definitely be part of this next phase of the study.

"The gastrointestinal tract of chickens have very similar features to that of humans," said Mahler. "We can learn a great deal from the way chicken tissue works which means we can make better predictions about how humans will react."

And humans certainly consume enough nanoparticles - about 100 trillion of them every day. Their ultra-small size and amazing qualities makes them increasingly common in food and pharmaceutical products. Although the impact of chronic exposure remains somewhat unknown, the ingestion of dietary particles is thought to promote a range of diseases, including Crohn's disease. With so many nanomaterials under development and with so much yet to be learned about nanoparticle toxicity and potential human tissue reactivity, Mahler and the team are hoping that their work, particularly the in vitro model, will provide an effective low-cost screening tool.

####

For more information, please click here

Contacts:
Gail Glover
or
Ryan Yarosh
607-777-2174

Copyright © Binghamton University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

Discoveries

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Silver nanowires demonstrate unexpected self-healing mechanism: The material has potential for flexible electronics January 23rd, 2015

Announcements

GS7 Graphene Sensor maybe Solution in Fight Against Cancer January 25th, 2015

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

Safety-Nanoparticles/Risk management

A spoonful of sugar in silver nanoparticles to regulate their toxicity January 21st, 2015

Nutrition, Safety Key To Consumer Acceptance of Nanotech, Genetic Modification In Foods December 2nd, 2014

Sustainable Nanotechnologies Project November 20th, 2014

A gut reaction November 19th, 2014

Research partnerships

Wearable sensor clears path to long-term EKG, EMG monitoring January 20th, 2015

Graphene enables all-electrical control of energy flow from light emitters: First signatures of graphene plasmons at telecommunications wavelength revealed January 20th, 2015

Charge instability detected across all types of copper-based superconductors: Findings may help researchers synthesize materials that can superconduct at room temperature January 16th, 2015

Gold nanoparticles show promise for early detection of heart attacks: NYU School of Engineering Professors collaborate with researchers from Peking University on a new test strip January 15th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE