Home > News > Drug Ups Effect of Gemcitabine in Pancreatic Cancer
March 1st, 2012
Drug Ups Effect of Gemcitabine in Pancreatic Cancer
Abstract:
Using a mouse model of pancreatic ductal adenocarcinoma, Kristopher K. Frese, Ph.D., and colleagues from the University of Cambridge in the United Kingdom, investigated the efficacy and mechanism of action of nanoparticle albumin-bound-paclitaxel combined with gemcitabine.
The researchers found that the combination treatment led to greater tumor regression and reduced tumor metastasis compared with gemcitabine alone. The increased efficacy was due to an increase in gemcitabine levels, which was due to a marked decrease in cytidine deaminase, which metabolizes gemcitabine. Paclitaxel degraded cytidine deaminase via reactive oxygen species.
"These data uncover novel insight into the antitumor activity of nanoparticle albumin-bound-paclitaxel and provide a distinct mechanism for improving gemcitabine delivery to pancreatic tumors that warrants further investigation in the clinical setting," Frese and colleagues conclude.
Source:
oncologynurseadvisor.com
Bookmark:
| Related News Press |
News and information
Simulating magnetization in a Heisenberg quantum spin chain April 5th, 2024
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
Nanomedicine
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Good as gold - improving infectious disease testing with gold nanoparticles April 5th, 2024
Researchers develop artificial building blocks of life March 8th, 2024
Discoveries
Chemical reactions can scramble quantum information as well as black holes April 5th, 2024
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Utilizing palladium for addressing contact issues of buried oxide thin film transistors April 5th, 2024
Announcements
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||