Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Biocompatible Quantum Dot Images Tumors in Live Animals

Abstract:
Quantum dots, small semiconductor nanoparticles that fluoresce brightly with sharply defined colors, have tremendous promise as biomedical imaging agents except for one problem—most are made from potentially hazardous materials such as cadmium and selenium. Now, however, a collaborative effort between researchers at Stanford University and Xiamen University in China has produced a stable, biocompatible quantum dot that appears to have the desired set of properties needed for biomedical imaging.

Biocompatible Quantum Dot Images Tumors in Live Animals

Bethesda, MD | Posted on January 19th, 2012

The team led by Zhen Cheng of Xiamen University and Sanjiv Gambhir of Stanford University School of Medicine reported its work in the journal Nano Letters. Dr. Gambhir is the co-principal investigator of the Stanford University Center for Cancer Nanotechnology Excellence and Translation.

To solve the biocompatibility problem, the investigators searched for semiconducting materials that had the desired optical properties of fluorescing in the near-infrared region of the spectrum and yet were not potentially toxic. They settled on a combination of indium phosphide and zinc sulfide and created a nanoparticle with an indium phosphide core and a zinc sulfide shell. The resulting quantum dots fluoresced brightly at 710 nanometers, a wavelength of light that passes through biological tissues and can be seen from within the body. To improve the pharmacological properties of the quantum dots—their ability to travel unimpeded through the blood stream, penetrate tissues, and reach biological targets—the researchers coated the nanoparticles with a biocompatible polymer known as a dendrimer. This coating also served as a convenient attachment point for a three amino acid peptide arginine-glycine-aspartic acid, known as RGD, that targets many types of tumors.

Tests with cancer cells and tumor-bearing animals demonstrated that these nanoprobes clearly imaged tumors known to bind to RGD. Because of their small size, the quantum dots accumulated in tumors via the leaky blood vessels that surround tumors. Biodistribution tests showed that approximately 60 percent of an injected dose of the new quantum dots was cleared from the body within a day, and that 100 percent clearance was achieved within one week. Equally important, animals dosed with this new type of nanoparticle experienced no apparent ill effects.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "A novel clinically translatable fluorescent nanoparticle for targeted molecular imaging of tumors in living subjects."

Related News Press

News and information

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

Imaging

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Govt.-Legislation/Regulation/Funding/Policy

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Discoveries

The quantum middle man July 2nd, 2015

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Announcements

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Quantum Dots/Rods

Producing spin-entangled electrons July 2nd, 2015

Philips Introduces Quantum Dot TV with Color IQ™ Technology from QD Vision: Manufacturer is first to offer quantum dot displays for both TVs and monitors June 30th, 2015

Biomanufacturing of CdS quantum dots: A bacterial method for the low-cost, environmentally-friendly synthesis of aqueous soluble quantum dot nanocrystals June 24th, 2015

Iranian Researchers Model, Design Optical Switches June 13th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project