Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Targeted immune stimulation based on DNA Nanotechnology

Abstract:
DNA is usually known as the genetic code for protein synthesis in all living organisms. The application of DNA as a molecular building block on the other hand, allows for the construction of sophisticated nanoscopic shapes that are built entirely from DNA. In particular the recent invention of the so-called DNA origami method facilitates the fabrication of almost all imaginable 3D shapes. Here a phage-based DNA strand is used as a scaffold that is woven into shape by hundreds of short staple oligonucleotides. The outstanding advantage of DNA-based self-assembly is that during a single fabrication process billion exact copies of the designed DNA nanostructure are produced in parallel.

Targeted immune stimulation based on DNA Nanotechnology

Munich, Germany | Posted on December 22nd, 2011

Now Prof. Tim Liedl, a member of NIM, and his team developed a DNA origami construct that serves as a carrier system to selectively stimulate immune responses of living cells. Together with the group of Prof. Carole Bourquin from the Klinikum der Universität München (KUM) the biophysicists investigated the systematic immune stimulatory effect and the potential cytotoxicity of these DNA nanostructures.

Our innate immune system can detect invasive organisms via a specific DNA motif, the so called CpG sequences ("Cytosine - phosphate - Guanine") which are prevalent in viruses and bacteria. When these sequences are internalized by certain immune cells, they are recognized by endosomal receptors like the Toll-Like Receptor 9 (TLR-9) which subsequently activate the immune system. The Toll-Like Receptors became famous at the latest in 2011, when Bruce Beutler and Jules Hoffmann received the Nobel Prize for their research on these kinds of receptors.

Verena Schüller from the Liedl group and her colleagues decorated a DNA origami construct with artificial CpG sequences and used it as an efficient non-toxic carrier system into cells. Together with the team of Carole Bourquin they demonstrated a selective immune stimulating effect of the DNA complexes by measuring the interleukin secretion of the cells as an indicator for immune activation. Such artificial nanostructures could act in future applications as target-selective delivery vehicles for the development of novel and non-toxic vaccine adjuvants or carrier systems in tumor immunotherapy.

Publication:

Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures. Verena Schüller, Simon Heidegger, Nadja Sandholzer, Philipp Nickels, Nina Suharta, Stefan Endres, Carole Bourquin and Tim Liedl. ACS Nano, 2011

####

For more information, please click here

Copyright © Nanosystems Initiative Munich

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Smaller, faster, cheaper: A new type of modulator for the future of data transmission July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Industrial Nanotech, Inc. Provides Update on PCAOB Audited Financials July 27th, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Discoveries

Smart hydrogel coating creates 'stick-slip' control of capillary action July 27th, 2015

Smaller, faster, cheaper: A new type of modulator for the future of data transmission July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Announcements

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Industrial Nanotech, Inc. Provides Update on PCAOB Audited Financials July 27th, 2015

Global Corrosion Resistant Nano Coatings Market To 2015: Acute Market Reports July 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project