Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Targeted immune stimulation based on DNA Nanotechnology

Abstract:
DNA is usually known as the genetic code for protein synthesis in all living organisms. The application of DNA as a molecular building block on the other hand, allows for the construction of sophisticated nanoscopic shapes that are built entirely from DNA. In particular the recent invention of the so-called DNA origami method facilitates the fabrication of almost all imaginable 3D shapes. Here a phage-based DNA strand is used as a scaffold that is woven into shape by hundreds of short staple oligonucleotides. The outstanding advantage of DNA-based self-assembly is that during a single fabrication process billion exact copies of the designed DNA nanostructure are produced in parallel.

Targeted immune stimulation based on DNA Nanotechnology

Munich, Germany | Posted on December 22nd, 2011

Now Prof. Tim Liedl, a member of NIM, and his team developed a DNA origami construct that serves as a carrier system to selectively stimulate immune responses of living cells. Together with the group of Prof. Carole Bourquin from the Klinikum der Universität München (KUM) the biophysicists investigated the systematic immune stimulatory effect and the potential cytotoxicity of these DNA nanostructures.

Our innate immune system can detect invasive organisms via a specific DNA motif, the so called CpG sequences ("Cytosine - phosphate - Guanine") which are prevalent in viruses and bacteria. When these sequences are internalized by certain immune cells, they are recognized by endosomal receptors like the Toll-Like Receptor 9 (TLR-9) which subsequently activate the immune system. The Toll-Like Receptors became famous at the latest in 2011, when Bruce Beutler and Jules Hoffmann received the Nobel Prize for their research on these kinds of receptors.

Verena Schüller from the Liedl group and her colleagues decorated a DNA origami construct with artificial CpG sequences and used it as an efficient non-toxic carrier system into cells. Together with the team of Carole Bourquin they demonstrated a selective immune stimulating effect of the DNA complexes by measuring the interleukin secretion of the cells as an indicator for immune activation. Such artificial nanostructures could act in future applications as target-selective delivery vehicles for the development of novel and non-toxic vaccine adjuvants or carrier systems in tumor immunotherapy.

Publication:

Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures. Verena Schüller, Simon Heidegger, Nadja Sandholzer, Philipp Nickels, Nina Suharta, Stefan Endres, Carole Bourquin and Tim Liedl. ACS Nano, 2011

####

For more information, please click here

Copyright © Nanosystems Initiative Munich

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Nanomedicine

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

Learning with light: New system allows optical “deep learning”: Neural networks could be implemented more quickly using new photonic technology June 12th, 2017

Mussels add muscle to biocompatible fibers: Rice University chemists develop hydrogel strings using compound found in sea creatures June 9th, 2017

Discoveries

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Atomic imperfections move quantum communication network closer to reality June 25th, 2017

Research accelerates quest for quicker, longer-lasting electronics: UC Riverside-led research makes topological insulators magnetic well above room temperatures June 25th, 2017

Announcements

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project