Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Novel nanoparticle mimicking virus offers new route to gene therapy

Abstract:
Researchers at Yale University have developed a novel nanoparticle with promising applications in gene therapy, a type of medical treatment that addresses the root causes of diseases now typically treated for symptoms.

Novel nanoparticle mimicking virus offers new route to gene therapy

New Haven, CT | Posted on December 7th, 2011

The advance could lead to new therapies for many forms of cancer, including brain tumors, as well as for cystic fibrosis and Huntington's Disease.

"The systems we developed could be used for any kind of gene therapy," said W. Mark Saltzman, professor and chair of biomedical engineering at Yale and a principal investigator of a paper on these findings, published Dec. 4 online in the journal Nature Materials. "Using novel chemistry, we synthesized a new family of polymers and produced materials that are unlike any that have been used before."

Saltzman and co-principal investigator Zhaozhong Jiang are both with Yale's School of Engineering & Applied Science.

Safe and highly efficient, the new, non-viral particle acts like a virus by introducing a specific gene into diseased cells in order to kill or repair them.

Other existing non-viral gene therapy agents have significant shortcomings, such as inefficiency or a strongly positive electric charge that can kill healthy cells. Viral gene therapy treatments can be dangerous because they can cause significant immune reactions.

The Yale team overcame the problem of excessive charge by making its nanoparticle more hydrophobic, or water-repellant, and thus less likely to form chemical bonds with water molecules. Specifically, the team incorporated safe, water-insoluble units into the polymer that generates the nanoparticles. This reduces the positive charge and increases stability. The result is an extremely safe mechanism for gene delivery that is more efficient than commercially available options.

"You can inject a lot of it into animals," said Saltzman. "It produces efficient gene delivery, but doesn't have any toxic effects."

The research team tested its nanoparticles both in vitro on cell culture and in vivo on a mouse tumor model.

Although the new materials can potentially be used for gene therapy in a wide variety of settings, Saltzman and his colleagues are particularly interested in using them in future research on treatments for brain tumors. Many experts believe that gene therapy is a promising approach for treating brain tumors, but prior research has been limited by the toxicity and low efficiency of the gene delivery materials. This new work provides a potential solution to these prior problems.

Additional authors of the paper are Jiangbing Zhou, Christopher J. Cheng and Caroline E. Weller, all of Yale's Department of Biomedical Engineering; Jie Liu of the School of Engineering at Sun Yat-sen University in China; Toral R. Patel and Joseph M. Piepmeier of Yale's Department of Neurosurgery.

Support for the research was provided by the National Institutes of Health, the Chicago Institute of Neurosurgery and Neuroresearch Foundation, the Voices Against Brain Cancer Foundation and the Yale Institute for Nanoscience and Quantum Engineering.

####

For more information, please click here

Contacts:
Eric Gershon
203-415-3108

Copyright © Yale University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to Saltzman's faculty page:

Related News Press

News and information

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

University of Illinois researchers create 1-step graphene patterning method April 27th, 2016

Nanograft seeded with 3 cell types promotes blood vessel formation to speed wound healing April 27th, 2016

NREL finds nanotube semiconductors well-suited for PV systems April 27th, 2016

Govt.-Legislation/Regulation/Funding/Policy

NREL finds nanotube semiconductors well-suited for PV systems April 27th, 2016

NREL theory establishes a path to high-performance 2-D semiconductor devices April 27th, 2016

Researchers create artificial protein to control assembly of buckyballs April 27th, 2016

Chemists use DNA to build the world's tiniest thermometer April 27th, 2016

Nanomedicine

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

Danish researchers behind vaccine breakthrough April 27th, 2016

Researchers create artificial protein to control assembly of buckyballs April 27th, 2016

Chemists use DNA to build the world's tiniest thermometer April 27th, 2016

Discoveries

Nanograft seeded with 3 cell types promotes blood vessel formation to speed wound healing April 27th, 2016

NREL finds nanotube semiconductors well-suited for PV systems April 27th, 2016

Danish researchers behind vaccine breakthrough April 27th, 2016

NREL theory establishes a path to high-performance 2-D semiconductor devices April 27th, 2016

Announcements

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

University of Illinois researchers create 1-step graphene patterning method April 27th, 2016

Researchers create artificial protein to control assembly of buckyballs April 27th, 2016

Chemists use DNA to build the world's tiniest thermometer April 27th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic