Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Cobblestones hoodwink innate immunity

Abstract:
Coating the surface of an implant such as a new hip or pacemaker with nanosized metallic particles reduces the risk of rejection, and researchers at the University of Gothenburg can now explain why: they fool the innate immune system. The results are presented in the International Journal of Nanomedicine.

Cobblestones hoodwink innate immunity

Gothenburg, Sweden | Posted on November 29th, 2011

"Activation of the body's innate immune system is one of the most common reasons for an implant being rejected," explains Professor Hans Elwing from the University of Gothenburg's Department of Cell and Molecular Biology. "We can now show why the body more easily integrates implants with a nanostructured surface than a smooth one."

The researchers used a unique method to produce nanostructures on gold surfaces, creating gold particles just 10-18 nm in diameter and binding them to a completely smooth gold surface at carefully regulated distances. The result is something akin to a cobbled street in miniature.
Nanosized irregularities mimic body's natural structures

Giving implants this cobbled surface reduces the activation of important parts of the innate immune system. This is because several of the proteins involved are of a similar size to these nanosized cobbles, and so do not change in appearance when they land on the surface. This gives the body a greater ability to integrate foreign objects such as implants, pacemakers and drug capsules into its own tissues, as well as reducing the risk of local inflammation.

"It may be that the innate immune system is designed to react to smooth surfaces, because these are not found naturally in the body," says Elwing. "Some bacteria, on the other hand, do have a completely smooth surface."

Modern nanotechnology makes it easy and cheap to surface-treat implants and drug capsules, but it will probably be several years before this becomes a reality in human medicine. The focus now is on customising titanium implants of various kinds.
Surface can be graded

"We've developed a graded surface with different cobbelstone package that we think can be used for bone implants," says Elwing. "Bone is very hard on the outside but then gets softer, so it would be good to have hard integration on the surface and softer integration underneath. We reckon we can make titanium screws that are denser at the head of the screw so that they fuse best at the top. This kind of customisation is the future."

Research into the body's innate immune system was rewarded this year with the Nobel Prize in Physiology or Medicine.

The laboratory work was carried out at the University of Gothenburg, and the project is a collaboration between the BIOMATCELL centre of excellence in Gothenburg, SP Technical Research Institute of Sweden in Borås and Bactiguard AB in Stockholm.

The article "Immune complement activation is attenuated by surface nanotopography" by Mats Hulander, Anders Lundgren, Mattias Berglin, Mattias Ohrlander, Jukka Lausmaa and Hans Elwing was published in the International Journal of Nanomedicine: dx.doi.org/10.2147/IJN.S24578

####

For more information, please click here

Contacts:
Anita Fors, Press Officer
Visiting Address:
Guldhedsgatan 5 A
Phone: 46 31 -786 98 73
Fax: 031-786 4839

Hans-Björne Elwing

46-031-786-2562

Copyright © University of Gothenburg

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The article “Immune complement activation is attenuated by surface nanotopography.”

Related News Press

News and information

ANU invention to inspire new night-vision specs December 7th, 2016

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Journal Nanotechnology Progress International (JONPI), newest edition out December 7th, 2016

In IEDM 2016 Keynote, Leti CEO Says ‘Hyperconnectivity’, Human-focused Research and the IOT Promise Profound, Positive Changes December 7th, 2016

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Discoveries

ANU invention to inspire new night-vision specs December 7th, 2016

Leti IEDM 2016 Paper Clarifies Correlation between Endurance, Window Margin and Retention in RRAM for First Time: Paper Presented at IEDM 2016 Offers Ways to Reconcile High-cycling Requirements and Instability at High Temperatures in Resistive RAM December 6th, 2016

Tokyo Institute of Technology research: 3D solutions to energy savings in silicon power transistors December 6th, 2016

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Announcements

ANU invention to inspire new night-vision specs December 7th, 2016

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Journal Nanotechnology Progress International (JONPI), newest edition out December 7th, 2016

In IEDM 2016 Keynote, Leti CEO Says ‘Hyperconnectivity’, Human-focused Research and the IOT Promise Profound, Positive Changes December 7th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project