Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors

Gold nanoparticle solutions and corresponding phantom images. Top: (a) Three nanoparticle solutions of varying shape and size (left to right: gold nanospheres, short gold nanorods, long gold nanorods). Bottom: Darkfield images of brain-simulating phantoms containing (b) 60nm gold nanospheres and (c) gold nanorods. (Scale bar=50 μm)

Credit: Kevin Seekell
Gold nanoparticle solutions and corresponding phantom images. Top: (a) Three nanoparticle solutions of varying shape and size (left to right: gold nanospheres, short gold nanorods, long gold nanorods). Bottom: Darkfield images of brain-simulating phantoms containing (b) 60nm gold nanospheres and (c) gold nanorods. (Scale bar=50 μm)

Credit: Kevin Seekell

Abstract:
"It's not brain surgery" is a phrase often uttered to dismiss a job's difficulty, but when the task actually is removing a brain tumor, even the slightest mistake could have serious health consequences. To help surgeons in such high-pressure situations, researchers from Prof. Adam Wax's team at Duke University's Fitzpatrick Institute for Photonics and Biomedical Engineering Department have proposed a way to harness the unique optical properties of gold nanoparticles to clearly distinguish a brain tumor from the healthy, and vital, tissue that surrounds it. The team will present their findings at the Optical Society's (OSA) Annual Meeting, Frontiers in Optics (FiO) 2011 (www.frontiersinoptics.com/), taking place in San Jose, Calif. next week.

Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors

Washington, DC | Posted on October 12th, 2011

Current techniques for outlining brain tumors vary, but all have limitations, such as the inability to perform real-time imaging without big, expensive equipment, or the toxicity and limited lifespan of certain labeling agents. Gold nanoparticles—which are so small that 500 of them end-to-end could fit across a human hair—might provide a better way to flag tumorous tissue, since they are non-toxic and relatively inexpensive to manufacture.

The Duke researchers synthesized gold, rod-shaped nanoparticles with varying length-to-width ratios. The different-sized particles displayed different optical properties, so by controlling the nanorods' growth the team could "tune" the particles to scatter a specific frequency of light. The researchers next joined the tuned particles to antibodies that bind to growth factor receptor proteins found in unusually high concentrations on the outside of cancer cells. When the antibodies latched on to cancer cells, the gold nanoparticles marked their presence.

The team tested the method by bathing slices of tumor-containing mouse brain in a solution of gold nanoparticles merged with antibodies. Shining the tuned frequency of light on the sample revealed bright points where the tumors lurked. The tunability of the gold nanoparticles is important, says team member Kevin Seekell, because it allows researchers to choose from a window of light frequencies that are not readily absorbed by biological tissue. It might also allow researchers to attach differently tuned nanoparticles to different antibodies, providing a way to diagnose different types of tumors based the specific surface proteins the cancer cells display. Future work by the team will also focus on developing a surgical probe that can image gold nanoparticles in a living brain, Seekell says.

FiO presentation FWL4, "Controlled Synthesis of Gold Nanorods and Application to Brain Tumor Delineation," by Kevin Seekell et al. is at 11:45 a.m. on Wednesday, Oct. 19.

####

About Optical Society of America
Uniting more than 130,000 professionals from 175 countries, the Optical Society (OSA) brings together the global optics community through its programs and initiatives. Since 1916 OSA has worked to advance the common interests of the field, providing educational resources to the scientists, engineers and business leaders who work in the field by promoting the science of light and the advanced technologies made possible by optics and photonics. OSA publications, events, technical groups and programs foster optics knowledge and scientific collaboration among all those with an interest in optics and photonics.

About the Meeting

Frontiers in Optics 2011 is OSA's 95th Annual Meeting and is being held together with Laser Science XXVII, the annual meeting of the American Physical Society (APS) Division of Laser Science (DLS). The two meetings unite the OSA and APS communities for five days of quality, cutting-edge presentations, fascinating invited speakers and a variety of special events spanning a broad range of topics in physics, biology and chemistry. FiO 2011 will also offer a number of Short Courses designed to increase participants' knowledge of a specific subject while offering the experience of insightful teachers. An exhibit floor featuring leading optics companies will further enhance the meeting.

For more information, please click here

Contacts:
Angela Stark

202-416-1443

Copyright © Optical Society of America

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Meeting home page:

Conference program:

Searchable abstracts:

Related News Press

News and information

Perfect diamagnetism observation of high-temperature superconductivity in compressed H2S June 14th, 2019

Mysterious Majorana quasiparticle is now closer to being controlled for quantum computing: Princeton researchers detect a robust Majorana quasiparticle and show how it can be turned on and off June 14th, 2019

University of Konstanz researchers create uniform-shape polymer nanocrystals: Researchers from the University of Konstanz's CRC 1214 'Anisotropic Particles as Building Blocks: Tailoring Shape, Interactions and Structures' generate uniform-shape nanocrystals using direct polymeriz June 14th, 2019

Small currents for big gains in spintronics: A new low-power magnetic switching component could aid spintronic devices June 14th, 2019

Imaging

New Video Highlights Specific Topics Sought in Call for Papers for the 2019 IEEE International Electron Devices Meeting (IEDM) June 13th, 2019

2D crystals conforming to 3D curves create strain for engineering quantum devices June 7th, 2019

New Argonne coating could have big implications for lithium batteries May 14th, 2019

Better microring sensors for optical applications May 10th, 2019

Nanomedicine

A molecular glue to overcome cancer drug resistance? Small molecule drug may prevent chemotherapy resistance June 7th, 2019

Arrowhead Pharmaceuticals to Present at Upcoming June 2019 Conferences June 2nd, 2019

Chemists build a better cancer-killing drill: Rice U.-designed molecular motors get an upgrade for activation with near-infrared light May 29th, 2019

Light and nanotechnology combined to prevent biofilms on medical implants May 24th, 2019

Discoveries

Perfect diamagnetism observation of high-temperature superconductivity in compressed H2S June 14th, 2019

Mysterious Majorana quasiparticle is now closer to being controlled for quantum computing: Princeton researchers detect a robust Majorana quasiparticle and show how it can be turned on and off June 14th, 2019

University of Konstanz researchers create uniform-shape polymer nanocrystals: Researchers from the University of Konstanz's CRC 1214 'Anisotropic Particles as Building Blocks: Tailoring Shape, Interactions and Structures' generate uniform-shape nanocrystals using direct polymeriz June 14th, 2019

Small currents for big gains in spintronics: A new low-power magnetic switching component could aid spintronic devices June 14th, 2019

Announcements

Perfect diamagnetism observation of high-temperature superconductivity in compressed H2S June 14th, 2019

Mysterious Majorana quasiparticle is now closer to being controlled for quantum computing: Princeton researchers detect a robust Majorana quasiparticle and show how it can be turned on and off June 14th, 2019

University of Konstanz researchers create uniform-shape polymer nanocrystals: Researchers from the University of Konstanz's CRC 1214 'Anisotropic Particles as Building Blocks: Tailoring Shape, Interactions and Structures' generate uniform-shape nanocrystals using direct polymeriz June 14th, 2019

Small currents for big gains in spintronics: A new low-power magnetic switching component could aid spintronic devices June 14th, 2019

Events/Classes

Arrowhead Pharmaceuticals to Present at Upcoming June 2019 Conferences June 2nd, 2019

ACS selects Naomi Halas to represent Americas at ChinaNano: Rice U. pioneer wins 2019 ACS Nano Lectureship Award for the Americas May 29th, 2019

CEA-Leti Develops CMOS Process for High-Performance MicroLEDs That Could Overcome Display-Size Obstacles: New Concept Creates All-in-One RGB MicroLEDs, Eliminates Several Transfer Steps to Receiving Substrate & Boosts Performance May 16th, 2019

Arrowhead Pharmaceuticals to Present at Upcoming May 2019 Conferences May 3rd, 2019

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project