Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanopores on a Chip: Applications for Analytical Tasks in Chemistry and Biology

Abstract:
Biological nanopores are proteins of only a few nanometers in diameter that form tiny water-filled canals. They have proven to be promising tools in the field of nanobiotechnology. In a joint project at the University of Freiburg, a research group led by Prof. Dr. Jan C. Behrends, Institute of Physiology, and scientists working under Prof. Dr. Jürgen Rühe, Department of Microsystems Technology (IMTEK), have succeeded in arranging nanopores on a tiny microchip and using it to determine the mass of chain-like molecules, so-called polymers, with a high degree of precision. In these experiments, the nanopores assume the role of the actual sensor.. The first author of the study, now published in the renowned journal ACSNano of the American Chemical Society, Dr. Gerhard Baaken, hopes that the new development will be instrumental in exploiting the great potential of nanopore analysis for chemistry and the life sciences.

Nanopores on a Chip: Applications for Analytical Tasks in Chemistry and Biology

Freiburg, Germany | Posted on October 7th, 2011

In their natural environment, nanopores often have the function of transporting larger molecules. For instance, they convey proteins through membranes. Bacteria also use nanopores to destroy the cells of infected organisms. This is also true of alpha-hemolysin, a protein produced by staphylococci to destroy red blood cells. This protein has also recently found applications in analytical tasks in chemistry and biology. If a large-sized molecule gets into the pore, it becomes partially blocked for fractions of a second. By measuring the electrical conductivity of the hemolysin pore, scientists can detect the presence of a single molecule—in a fashion similar to the function of a light barrier. By the same principle it is also possible to make a very precise measurement of the size of the molecule. Scientists are very optimistic about the potential applications—not only for the analysis of synthetic polymer mixtures, but also for the analysis of genetic material and even as a quick and inexpensive way to sequence DNA.

The Freiburg research team has now succeeded in conducting such measurements on a specially developed biohybrid microsensor made of biological and micro-technical parts. It contains 16 miniaturized artificial cell membranes on only one square millimeter. The individual membranes are spread over minuscule pits, each with a diameter of approximately two-hundredths of a millimeter. That is the equivalent of around one-third of the thickness of a human hair. In their publication, the authors demonstrate that they can use the chip to obtain the distributions of polymer sizes that are accurate to a single chain element. Currently, results of such precision require expensive equipment filling entire rooms. The project is a good example of successful collaboration among strongly diverging disciplines.

####

For more information, please click here

Contacts:
Dr. Gerhard Baaken
Department of Microsystems Engineering (IMTEK)
University of Freiburg
Phone: 0761-203-5145


Prof. Dr. Jan Behrends
Institute of Physiology
University of Freiburg
Phone: 0761-203-5146


Melanie Hübner
+49 (0) 761/203-4302

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Sensors

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

LetiDays Grenoble to Present Multiple Perspectives on Development, Challenges and Markets for the IoT April 14th, 2014

Discoveries

Like a hall of mirrors, nanostructures trap photons inside ultrathin solar cells April 22nd, 2014

Nanomaterial Outsmarts Ions April 22nd, 2014

Vacuum Ultraviolet Lamp of the Future Created in Japan: First Solid-State Vacuum UV Phosphor, Described in APL-Materials, Promises Smaller, Safer, Longer Lasting, Low Power Lamps for Industrial Applications April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Announcements

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Nanobiotechnology

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

In latest generation of tiny biosensors, size isn't everything: UCLA researchers overturn conventional wisdom on nanowire-based diagnostic devices April 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE