Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Responsive Labels for Cells

Abstract:
How do you stick a label on something as small as a cell? Cell-labeling techniques are explained, and the use of polymer-coated nanoparticles as environment-sensitive cell labels is demonstrated by scientists in Germany and Australia.

Responsive Labels for Cells

Melbourne, Australia and Marburg, Germany | Posted on September 22nd, 2011

Many scientists are rising to the challenge of effective cell labeling by using nanoparticles as labels; these labels may be either fluorescent, magnetic, or radioactive. Nanoparticles are ideal for this purpose because they are smaller than a cell and can be taken up via the cell machinery and they can be made biocompatible. Nanoparticles can also have properties that make them easily observed from the outside, like fluorescence or magnetism. However water-soluble nanoparticles are not easy to make on a large scale, which can limit their use.

Paul Mulvaney (University of Melbourne, Australia), Wolfgang Parak (Philipps University of Marburg, Germany), and co-workers have reviewed attempts to date to make many sorts of nanoparticles soluble in water. They describe different approaches taken by various scientists, including ligand exchange and encapsulation.

Ligand exchange is useful because the smallest water-soluble nanoparticles can be made in this way, but it can reduce the quantum yield of fluorescent particles and the stability of all particles. This method can, however, be very useful to introduce new functional groups to the particle surface.

Encapsulation of nanoparticles with silica or polymers is another approach to increasing their water-solubility. Growing a silica shell around the particle adds both solubility and chemical functionality, but involves a complex procedure, whereas surrounding the nanoparticle with a layer of polymer that is attracted to both water and the particle can be relatively straightforward to achieve by self-assembly and the procedure does not change much for different particles, which makes it universal. Polymer-coated nanoparticles are very stable, but larger than those produced by ligand exchange.

The researchers don't stop there; they expand upon work they've done using polymer-coated nanoparticles to make sense of cell behavior. In particular, if a pH-sensitive and fluorescent polymer is chosen to coat the nanoparticles, then information can be gleaned about uptake into cells of the particle and any changes in the environment once it is there. So scientists truly can put responsive labels into cells, which should enable us to understand cell behavior better in the future.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

Discoveries

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Announcements

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Nanobiotechnology

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope December 15th, 2014

Biomimetic dew harvesters: Understanding how a desert beetle harvests water from dew could improve drinking water collection in dew condensers December 8th, 2014

Research partnerships

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Unraveling the light of fireflies December 17th, 2014

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE