Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UNC scientist proves potential of new nanoparticle design for cancer therapy

Wenbin Lin, Ph.D., of the University of North Carolina at Chapel Hill, is corresponding author of the study.

Credit: UNC Lineberger Comprehensive Cancer Center
Wenbin Lin, Ph.D., of the University of North Carolina at Chapel Hill, is corresponding author of the study.

Credit: UNC Lineberger Comprehensive Cancer Center

Abstract:
A new type of nanoparticle developed in the laboratories at the University of North Carolina has shown potential for more effective delivery of chemotherapy to treat cancer. Wenbin Lin, PhD, Kenan Distinguished Professor of Chemistry and Pharmacy, and colleagues report their finding in the Sept. 14, 2011 issue of Angewandte Chemie, the German-based flagship chemistry journal.

UNC scientist proves potential of new nanoparticle design for cancer therapy

Chapel Hill, NC | Posted on September 20th, 2011

In laboratory studies, Lin and colleagues developed and tested a new type of nanoparticle that can deliver larger amounts of a drug and will not leak the drug as the particle circulates through the blood stream on its way to the target.

In the proof-of-concept experiments, they tested the nanoparticle's ability to deliver therapeutic doses of the chemotherapy drug oxaliplatin to colon and pancreatic tumors. The oxaliplatin-based particles showed significant growth inhibition of pancreatic tumors that are extremely difficult to treat. The nanoparticle has two to three times therapeutic efficacy over oxaliplatin.

The nanoparticle is different from other nanoparticles in its very high drug loading and in the ability to release in the chemotherapeutics in a controlled fashion. The release of therapeutic cargoes depends on the naturally occurring molecules that are more abundant in many tumors.

Lin explains, "The polysilsesquioxane (PSQ) particle we have developed carries extremely high loadings of oxaliplatin-based chemotherapeutics. The particles are stable under normal physiological conditions, but can be readily reduced to release the platin cargoes in highly reducing tumor microenvironments that have high concentrations of reducing agents. As a result, they have very little background release and are more easily targeted to tumors than most existing particles. We need to thoroughly determine the pharmacokinetics and other important properties of the PSQparticle in order to translate this particle platform to the clinic."

Other UNC scientists involved in the research are graduate students Joseph Della Rocca, BS; Rachel C. Huxford, MS; and Erica Comstock-Duggan, BS.

This work is supported by 2010 funding from the National Cancer Institute's Cancer Nanotechnology Platform Partnerships and the Carolina Center of Cancer Nanotechnology Excellence. These 12 partnerships and 9 centers were designed to promote and support individual, circumscribed multi-disciplinary research projects that will address major barriers and fundamental questions in cancer using innovative nanotechnology solutions.

####

For more information, please click here

Contacts:
Dianne Shaw

919-966-7834

Copyright © University of North Carolina School of Medicine

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Govt.-Legislation/Regulation/Funding/Policy

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

'Electronic skin' could improve early breast cancer detection October 29th, 2014

Nanomedicine

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Production of Biocompatible Polymers in Iran October 30th, 2014

Amorphous Coordination Polymer Particles as alternative to classical nanoplatforms for nanomedicine October 30th, 2014

'Electronic skin' could improve early breast cancer detection October 29th, 2014

Discoveries

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Announcements

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE