Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > UNC scientist proves potential of new nanoparticle design for cancer therapy

Wenbin Lin, Ph.D., of the University of North Carolina at Chapel Hill, is corresponding author of the study.

Credit: UNC Lineberger Comprehensive Cancer Center
Wenbin Lin, Ph.D., of the University of North Carolina at Chapel Hill, is corresponding author of the study.

Credit: UNC Lineberger Comprehensive Cancer Center

Abstract:
A new type of nanoparticle developed in the laboratories at the University of North Carolina has shown potential for more effective delivery of chemotherapy to treat cancer. Wenbin Lin, PhD, Kenan Distinguished Professor of Chemistry and Pharmacy, and colleagues report their finding in the Sept. 14, 2011 issue of Angewandte Chemie, the German-based flagship chemistry journal.

UNC scientist proves potential of new nanoparticle design for cancer therapy

Chapel Hill, NC | Posted on September 20th, 2011

In laboratory studies, Lin and colleagues developed and tested a new type of nanoparticle that can deliver larger amounts of a drug and will not leak the drug as the particle circulates through the blood stream on its way to the target.

In the proof-of-concept experiments, they tested the nanoparticle's ability to deliver therapeutic doses of the chemotherapy drug oxaliplatin to colon and pancreatic tumors. The oxaliplatin-based particles showed significant growth inhibition of pancreatic tumors that are extremely difficult to treat. The nanoparticle has two to three times therapeutic efficacy over oxaliplatin.

The nanoparticle is different from other nanoparticles in its very high drug loading and in the ability to release in the chemotherapeutics in a controlled fashion. The release of therapeutic cargoes depends on the naturally occurring molecules that are more abundant in many tumors.

Lin explains, "The polysilsesquioxane (PSQ) particle we have developed carries extremely high loadings of oxaliplatin-based chemotherapeutics. The particles are stable under normal physiological conditions, but can be readily reduced to release the platin cargoes in highly reducing tumor microenvironments that have high concentrations of reducing agents. As a result, they have very little background release and are more easily targeted to tumors than most existing particles. We need to thoroughly determine the pharmacokinetics and other important properties of the PSQparticle in order to translate this particle platform to the clinic."

Other UNC scientists involved in the research are graduate students Joseph Della Rocca, BS; Rachel C. Huxford, MS; and Erica Comstock-Duggan, BS.

This work is supported by 2010 funding from the National Cancer Institute's Cancer Nanotechnology Platform Partnerships and the Carolina Center of Cancer Nanotechnology Excellence. These 12 partnerships and 9 centers were designed to promote and support individual, circumscribed multi-disciplinary research projects that will address major barriers and fundamental questions in cancer using innovative nanotechnology solutions.

####

For more information, please click here

Contacts:
Dianne Shaw

919-966-7834

Copyright © University of North Carolina School of Medicine

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

National Conference on Nanomaterials, (NCN-2017) April 21st, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

Govt.-Legislation/Regulation/Funding/Policy

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Better living through pressure: Functional nanomaterials made easy April 19th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Emergency Use Authorization for Gene-RADAR® Zika Virus Test: FDA Authorization for the Gene-RADAR® Zika Virus Test on the XPRIZE-Winning Gene-RADAR® Platform April 14th, 2017

Nanomedicine

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

Emergency Use Authorization for Gene-RADAR® Zika Virus Test: FDA Authorization for the Gene-RADAR® Zika Virus Test on the XPRIZE-Winning Gene-RADAR® Platform April 14th, 2017

Discoveries

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

Wood filter removes toxic dye from water April 21st, 2017

Rice crew revved for Nanocar Race: Nanocar creator James Tour and team take on international competition with single-molecule marvel April 20th, 2017

Better living through pressure: Functional nanomaterials made easy April 19th, 2017

Announcements

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

National Conference on Nanomaterials, (NCN-2017) April 21st, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project