Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UNC scientist proves potential of new nanoparticle design for cancer therapy

Wenbin Lin, Ph.D., of the University of North Carolina at Chapel Hill, is corresponding author of the study.

Credit: UNC Lineberger Comprehensive Cancer Center
Wenbin Lin, Ph.D., of the University of North Carolina at Chapel Hill, is corresponding author of the study.

Credit: UNC Lineberger Comprehensive Cancer Center

Abstract:
A new type of nanoparticle developed in the laboratories at the University of North Carolina has shown potential for more effective delivery of chemotherapy to treat cancer. Wenbin Lin, PhD, Kenan Distinguished Professor of Chemistry and Pharmacy, and colleagues report their finding in the Sept. 14, 2011 issue of Angewandte Chemie, the German-based flagship chemistry journal.

UNC scientist proves potential of new nanoparticle design for cancer therapy

Chapel Hill, NC | Posted on September 20th, 2011

In laboratory studies, Lin and colleagues developed and tested a new type of nanoparticle that can deliver larger amounts of a drug and will not leak the drug as the particle circulates through the blood stream on its way to the target.

In the proof-of-concept experiments, they tested the nanoparticle's ability to deliver therapeutic doses of the chemotherapy drug oxaliplatin to colon and pancreatic tumors. The oxaliplatin-based particles showed significant growth inhibition of pancreatic tumors that are extremely difficult to treat. The nanoparticle has two to three times therapeutic efficacy over oxaliplatin.

The nanoparticle is different from other nanoparticles in its very high drug loading and in the ability to release in the chemotherapeutics in a controlled fashion. The release of therapeutic cargoes depends on the naturally occurring molecules that are more abundant in many tumors.

Lin explains, "The polysilsesquioxane (PSQ) particle we have developed carries extremely high loadings of oxaliplatin-based chemotherapeutics. The particles are stable under normal physiological conditions, but can be readily reduced to release the platin cargoes in highly reducing tumor microenvironments that have high concentrations of reducing agents. As a result, they have very little background release and are more easily targeted to tumors than most existing particles. We need to thoroughly determine the pharmacokinetics and other important properties of the PSQparticle in order to translate this particle platform to the clinic."

Other UNC scientists involved in the research are graduate students Joseph Della Rocca, BS; Rachel C. Huxford, MS; and Erica Comstock-Duggan, BS.

This work is supported by 2010 funding from the National Cancer Institute's Cancer Nanotechnology Platform Partnerships and the Carolina Center of Cancer Nanotechnology Excellence. These 12 partnerships and 9 centers were designed to promote and support individual, circumscribed multi-disciplinary research projects that will address major barriers and fundamental questions in cancer using innovative nanotechnology solutions.

####

For more information, please click here

Contacts:
Dianne Shaw

919-966-7834

Copyright © University of North Carolina School of Medicine

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

HP Supercomputer at NREL Garners Top Honor October 19th, 2014

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Ucore's McKenzie to Deliver Presentation to Rare Earths Conference in Singapore as Highlight of Fall 2014 Marketplace Schedule October 19th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

Govt.-Legislation/Regulation/Funding/Policy

HP Supercomputer at NREL Garners Top Honor October 19th, 2014

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

QD Vision Wins Prestigious Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency October 16th, 2014

Nanomedicine

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

European Commission opens the gate towards the implementation of Nanomedicine Translation Hub October 16th, 2014

Nanodevices for clinical diagnostic with potential for the international market: The development is based on optical principles and provides precision and allows saving vital time for the patient October 15th, 2014

Tuning light to kill deep cancer tumors: Nanoparticles developed at UMass Medical School advance potential clinical application for photodynamic therapy October 15th, 2014

Discoveries

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanotechnology Improves Quality of Anti-Corrosive Coatings October 17th, 2014

Announcements

HP Supercomputer at NREL Garners Top Honor October 19th, 2014

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Ucore's McKenzie to Deliver Presentation to Rare Earths Conference in Singapore as Highlight of Fall 2014 Marketplace Schedule October 19th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE