Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researchers provide means of monitoring cellular interactions: A new technology for monitoring cellular interactions at the nano-scale provides detail never before achieved

Using nanotechnology to engineer sensors onto the surface of cells, researchers at Brigham and Women's Hospital (BWH) have developed a platform technology for monitoring single-cell interactions in real-time. Sensing the niche - Cells carrying sensors monitor the cellular nano-environment in real-time.

Credit: Courtesy of Brigham and Women's Hospital
Using nanotechnology to engineer sensors onto the surface of cells, researchers at Brigham and Women's Hospital (BWH) have developed a platform technology for monitoring single-cell interactions in real-time. Sensing the niche - Cells carrying sensors monitor the cellular nano-environment in real-time.

Credit: Courtesy of Brigham and Women's Hospital

Abstract:
Using nanotechnology to engineer sensors onto the surface of cells, researchers at Brigham and Women's Hospital (BWH) have developed a platform technology for monitoring single-cell interactions in real-time. This innovation addresses needs in both science and medicine by providing the ability to further understand complex cell biology, track transplanted cells, and develop effective therapeutics. These findings are published in the July 17 issue of Nature Nanotechnology.

Researchers provide means of monitoring cellular interactions: A new technology for monitoring cellular interactions at the nano-scale provides detail never before achieved

Boston, MA | Posted on July 17th, 2011

"We can now monitor how individual cells talk to one another in real-time with unprecedented spatial and temporal resolution," says Jeffrey Karp, senior study author, and co-director of the Center for Regenerative Therapeutics (ReGen Rx) at BWH. "This allows us to understand signaling between cells and interactions with drugs in great detail that should have broad implications for basic science and drug discovery",.

The cell-signaling sensors researchers currently use are limited to measuring the activity in the bulk environment that a group of cells are in. In this study, researchers used nanotechnology to anchor a sensor to the membrane of individual cells, allowing them to monitor soluble signals within the cellular nanoenvironment. Given that cells are directly labeled with sensors permits application to transplanted cells or tissues.

"Once this is refined as a tool, and used to study drug interactions with cells on a regular basis, there is potential that it may be used for personalized medicine in the future," said Weian Zhao, lead author of the study, also of the Center for Regenerative Therapeutics (ReGen Rx) at BWH. Karp adds, "We may one day be able to test a drug's influence on cell-cell interactions before deciding on the appropriate therapeutic for each person."

The researchers are also especially excited by preliminary data that demonstrates the potential to use this engineering approach to track and monitor the environment surrounding transplanted cells, in real time, which was never before possible. This would be useful for developing a deeper understanding of signaling events that define a site of inflammation for example or the stem cell niche, which may have implications for treatment of many diseases.

"This new study takes a significant step toward the goal to eavesdrop in real-time and at high spatial resolution on communications between cells in their native environment, with far-reaching implications for the development of new drugs and diagnostics" said Ulrich von Andrian, the Mallinckrodt Professor of Immunopathology at Harvard Medical School who was not involved in this study.

This work was funded by the National Institutes of Health and the American Heart Association.

####

About Brigham and Women's Hospital
Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative.

For more information, please click here

Contacts:
Holly Brown-Ayers

617-534-1603

Copyright © Brigham and Women's Hospital

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Nanomedicine

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Sensors

The next generation of carbon monoxide nanosensors May 26th, 2016

Dartmouth team creates new method to control quantum systems May 24th, 2016

Electronic device detects molecules linked to cancer, Alzheimer's and Parkinson's: An inexpensive portable biosensor has been developed by researchers at Brazil's National Nanotechnology Laboratory with FAPESP's support May 20th, 2016

Making organs transparent to improve nanomedicine (video) May 13th, 2016

Discoveries

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Announcements

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Nanobiotechnology

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic