- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
Scientists at the University of Southampton have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumours.
The team of researchers, led by Physics lecturer Dr Antonios Kanaras, showed that a small dose of gold nanoparticles can activate or inhibit genes that are involved in angiogenesis - a complex process responsible for the supply of oxygen and nutrients to most types of cancer.
"The peptide-functionalised gold nanoparticles that we synthesised are very effective in the deliberate activation or inhibition of angiogenic genes," said Dr Kanaras.
The team went a step further to control the degree of damage to the endothelial cells using laser illumination. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis.
The researchers also found that the gold particles could be used as effective tools in cellular nanosurgery.
Dr Kanaras adds: "We have found that gold nanoparticles can have a dual role in cellular manipulation. Applying laser irradiation, we can use the nanoparticles either to destroy endothelial cells, as a measure to cut the blood supply to tumours, or to deliberately open up the cellular membrane in order to deliver a drug efficiently."
The researchers have published two related papers (NanoLett. 2011, 11 (3), 1358-1363; Small 2011, 7, No. 3, 388-394) with another one submitted for publication and four more planned throughout this year. Their major target is to develop a complete nanotechnology toolkit to manipulate angiogenesis.
For more information, please click here
Media Relations office
Tel. 44 023 8059 3212
Copyright © University of SouthamptonIf you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016
Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016