Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > JPK's ForceRobot system produces high volume single molecule force spectroscopy results at the University of Nebraska

Dr. Alexey Krasnoslobodtsev working with the JPK ForceRobot® 300 system
Dr. Alexey Krasnoslobodtsev working with the JPK ForceRobot® 300 system

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the work from the Pharmaceutical Sciences Department of the Medical School at the University of Nebraska. The Department has selected the JPK ForceRobot® 300 system to extend their studies applying atomic force microscopy, AFM, in the measurement of single molecule force spectroscopy.

JPK's ForceRobot system produces high volume single molecule force spectroscopy results at the University of Nebraska

Berlin, Germany | Posted on June 7th, 2011

Professor Yuri Lyubchenko heads a research group at UNMC in genomics. Their goal is to unravel the role of the DNA dynamics at different levels as key mechanisms for various DNA functions including gene regulation, DNA recombination and the mismatch repair with the major focus on DNA recombination. The misfolding and aggregation of proteins are widespread phenomena leading to the development of numerous neurodegenerative disorders for which there is currently no cure.

Lyubchenko's group has published widely using AFM as both a direct and complimentary tool to advance their understanding of biological processes, some of which are relevant to human health. Single molecule force spectroscopy is used to study interactions between peptides and proteins involved in the development of these neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. AFM helps to bridge the gap of various techniques which are capable of looking at the complex processes of protein misfolding and aggregation. However, it has the drawback of being very time and labor consuming to make measurements. This has been solved by the introduction of JPK's ForceRobot® 300 system into the group.

One of the key researchers in the group is Dr. Alexey Krasnoslobodtsev. He did his first degree in Chemistry at Novosibirsk State University before completing his PhD at the New Mexico State University. Speaking about his research, Krasnoslobodtsev says "AFM is my instrument of choice in my work towards a better understanding of these protein misfolding and aggregation phenomena. By measuring strength of interactions between protein molecules, it is possible to detect pathological misfolded conformations of proteins which are capable of triggering aggregation. Such conformations are characterized by elevated propensity to interact with one another. It is hoped that better understanding the mechanisms underlying self-assembly of proteins and peptides into nano-aggregates of various sizes and morphologies would eventually facilitate the development of efficient therapeutic and diagnostic tools for diseases associated with protein misfolding."

He continues: "The first time I saw a presentation about ForceRobot was at the Biophysical Society meeting in 2007. I remember sharing my excitement with my colleagues in the lab after I got back. The ForceRobot seemed to have the ability to take over the tedious routine manipulations like data acquisition and analysis leaving more time for conceiving ideas and thinking about science. Although, much is still in the hands of the researcher, for example sample preparation and data interpretation, automated data collection makes it much easier to carry out an experiment. For example, when I come to work in the morning and find ForceRobot (which was left running overnight) is about to finish collecting thousands of force curves, I feel really excited because I can look at the data right away."

JPK develops, engineers and manufactures instrumentation in Germany to the world-recognized standards of German precision engineering, quality and functionality. For further details of the ForceRobot® 300 and other products in the JPK family of nanoscale characterization instrumentation, please visit the JPK web site (www.jpk.com) or Facebook (www.jpk.com/facebook).

####

About JPK Instruments (JPK)
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK’s success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo (Japan) and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For further information, please contact JPK direct or their marketing partners, NetDyaLog, who will also provide high resolution images for your use.

For more information, please click here

Contacts:
Jezz Leckenby
NetDyaLog Limited
T: +44 (0) 1799 521881
M: +44 (0) 7843 012997

or
Claudia Boettcher
JPK Instruments
T: +49 (0) 30 5331 12070

Copyright © JPK Instruments (JPK)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Leti Announces EU Project to Develop Powerful, Inexpensive Sensors with Photonic Integrated Circuits: REDFINCH Members Initially Targeting Applications for Gas Detection and Analysis For Refineries & Petrochemical Industry and Protein Analysis for Dairy Industry September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Announcements

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Leti Announces EU Project to Develop Powerful, Inexpensive Sensors with Photonic Integrated Circuits: REDFINCH Members Initially Targeting Applications for Gas Detection and Analysis For Refineries & Petrochemical Industry and Protein Analysis for Dairy Industry September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Tools

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung. September 12th, 2018

Terahertz spectroscopy enters the single-molecule regime September 7th, 2018

Mirrorcle Demonstrates MEMS-based Programmable Light Source at CES and PW18 August 30th, 2018

Stress-free ALD from Picosun August 28th, 2018

New-Contracts/Sales/Customers

Nanometrics Delivers 100th: Atlas III System for Advanced Process Control Metrology Atlas III: Systems are qualified and in production for advanced devices in DRAM, 3D-NAND and Foundry/Logic August 2nd, 2018

Picosun’s ALD solutions make quality watches tick July 26th, 2018

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides July 13th, 2018

Oxford Instruments’ 22 Tesla superconducting magnet system commissioned at the UAM, making it the most intense magnetic field available outside a large international facility July 12th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project