Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Research creates nanoparticles perfectly formed to tackle cancer

Abstract:
Researchers from the University of Hull have discovered a way to load up nanoparticles with large numbers of light-sensitive molecules to create a more effective form of photodynamic therapy (PDT) for treating cancer.

Research creates nanoparticles perfectly formed to tackle cancer

UK | Posted on June 6th, 2011

Photodynamic therapy uses molecules which, when irradiated with light, cause irreparable damage to cells by creating toxic forms of oxygen, called reactive oxygen species. Most PDT works with individual light-sensitive molecules - but the new nanoparticles could each carry hundreds of molecules to a cancer site.

A number of different light-sensitive molecules - collectively known as photosensitisers - are used in PDT and each absorbs a very specific part of the light spectrum. The research team - from the University of Hull's Department of Chemistry - placed one kind of photosensitiser inside each nanoparticle and another on the outside, which meant that far more reactive oxygen species could be created from the same amount of light. The findings are published in the current issue of Molecular Pharmaceutics.

The nanoparticles have also been designed to be the perfect size and shape to penetrate easily into the tumour, as lead researcher, Dr Ross Boyle, explains.

"Small cancer tumours get nutrients and oxygen by diffusion, but once tumours reach a certain size, they need to create blood vessels to continue growing, " he says. "These new blood vessels, or neovasculature, are 'leaky' because the vessel walls are not as tightly knit as normal blood vessels. Our nanoparticles have been designed so the pressure in the blood vessels will push them through the space between the cells to get into the tumour tissue."

The nanoparticles are made from a material that limits the leaching of its contents while in the bloodstream, but when activated with light, at the tumour, the toxic reactive oxygen species can diffuse freely out of the particles; meaning that damage is confined to the area of the cancer.

The researchers tested the nanoparticles on colon cancer cells, and while they were able to penetrate the cells, they also found that the nanoparticles could still be effective when near - rather than inside - the cancer cells.

"Some types of cancer cell are able to expel conventional drugs, so if we can make this kind of therapy work simply by getting the nanoparticles between the cancer cells, rather than inside them, it could be very beneficial," says Dr Boyle.

####

For more information, please click here

Contacts:
Dr Ross Boyle

44-148-246-6353

Copyright © University of Hull

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

Ageing can drive progress: Population ageing is likely to boost medicine, nanotechnology and robotics, but increase political risks July 27th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

Nanomedicine

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

Discoveries

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

New nontoxic process promises larger ultrathin sheets of 2-D nanomaterials July 27th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Announcements

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

Ageing can drive progress: Population ageing is likely to boost medicine, nanotechnology and robotics, but increase political risks July 27th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

Photonics/Optics/Lasers

Attosecond physics: Mapping electromagnetic waveforms July 25th, 2016

RMIT researchers make leap in measuring quantum states July 21st, 2016

The birth of quantum holography: Making holograms of single light particles! July 21st, 2016

Graphene photodetectors: Thinking outside the 2-D box July 21st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic