Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Research creates nanoparticles perfectly formed to tackle cancer

Abstract:
Researchers from the University of Hull have discovered a way to load up nanoparticles with large numbers of light-sensitive molecules to create a more effective form of photodynamic therapy (PDT) for treating cancer.

Research creates nanoparticles perfectly formed to tackle cancer

UK | Posted on June 6th, 2011

Photodynamic therapy uses molecules which, when irradiated with light, cause irreparable damage to cells by creating toxic forms of oxygen, called reactive oxygen species. Most PDT works with individual light-sensitive molecules - but the new nanoparticles could each carry hundreds of molecules to a cancer site.

A number of different light-sensitive molecules - collectively known as photosensitisers - are used in PDT and each absorbs a very specific part of the light spectrum. The research team - from the University of Hull's Department of Chemistry - placed one kind of photosensitiser inside each nanoparticle and another on the outside, which meant that far more reactive oxygen species could be created from the same amount of light. The findings are published in the current issue of Molecular Pharmaceutics.

The nanoparticles have also been designed to be the perfect size and shape to penetrate easily into the tumour, as lead researcher, Dr Ross Boyle, explains.

"Small cancer tumours get nutrients and oxygen by diffusion, but once tumours reach a certain size, they need to create blood vessels to continue growing, " he says. "These new blood vessels, or neovasculature, are 'leaky' because the vessel walls are not as tightly knit as normal blood vessels. Our nanoparticles have been designed so the pressure in the blood vessels will push them through the space between the cells to get into the tumour tissue."

The nanoparticles are made from a material that limits the leaching of its contents while in the bloodstream, but when activated with light, at the tumour, the toxic reactive oxygen species can diffuse freely out of the particles; meaning that damage is confined to the area of the cancer.

The researchers tested the nanoparticles on colon cancer cells, and while they were able to penetrate the cells, they also found that the nanoparticles could still be effective when near - rather than inside - the cancer cells.

"Some types of cancer cell are able to expel conventional drugs, so if we can make this kind of therapy work simply by getting the nanoparticles between the cancer cells, rather than inside them, it could be very beneficial," says Dr Boyle.

####

For more information, please click here

Contacts:
Dr Ross Boyle

44-148-246-6353

Copyright © University of Hull

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

Nanomedicine

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Discoveries

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Announcements

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

Photonics/Optics/Lasers

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Quantum diffraction at a breath of nothing: Physicists build stable diffraction structure in atomically thin graphene August 25th, 2015

Nanotechnology that will impact the Security & Defense sectors to be discussed at NanoSD2015 conference August 25th, 2015

A little light interaction leaves quantum physicists beaming August 25th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic