Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Porous Nanoparticles Deliver Drug Cocktails to Tumors

Abstract:
Melding nanotechnology and medical research, researchers from Sandia National Laboratories, the University of New Mexico, and the UNM Cancer Research and Treatment Center have produced an effective strategy that uses nanoparticles to treat tumors with a mélange of anticancer agents. This strategy relies on using silica nanoparticles honeycombed with cavities that can store large amounts and varieties of drugs loaded inside a lipid-based nanoparticle known as a liposome.

Porous Nanoparticles Deliver Drug Cocktails to Tumors

Bethesda, MD | Posted on May 29th, 2011

"The enormous capacity of the nanoporous core, with its high surface area, combined with the improved targeting of an encapsulating lipid bilayer, permits a single 'protocell' loaded with a drug cocktail to kill a drug-resistant cancer cell," says team leader Jeff Brinker, who is the co-principal investigator of the University of New Mexico Cancer Nanotechnology Platform Partnership. "That's a millionfold increase in efficiency over comparable methods employing liposomes alone — without nanoparticles — as drug carriers." Dr. Brinker and his team published the results of their work in the journal Nature Materials.

The nanoparticles and the surrounding cell-like membranes formed from liposomes create what the researchers call a protocell: the membrane seals in the deadly cargo and is modified with targeting molecules that bind specifically to receptors overexpressed on the cancer cell's surface. The nanoparticles provide stability to the supported membrane and release the therapeutic cargo within the cell.

A current Food and Drug Administration-approved nanoparticle delivery strategy is to use liposomes themselves to contain and deliver the cargo. In a head-to-head comparison of targeted liposomes and protocells with identical membrane and peptide compositions, Dr. Brinker and colleagues report that the greater cargo capacity, stability, and targeting efficacy of protocells leads to a drug formulation that is much more effective at killing human liver cancer cells.

Another advantage to protocells over liposomes alone is that it is far easier to load drugs into the porous nanoparticles than it is with liposomes. Loading drugs into liposomes requires complex strategies that boost the cost of making those formulations. In contrast, loading the porous nanoparticles can be done by simply soaking the nanoparticles in a drug solution. The liposome then serves as a shield that restricts toxic chemotherapy drugs from leaking from the nanoparticle until the protocell binds to the cancer cell. This means that only low levels of anticancer agents, at most, escape into the blood stream or attack other cells.

####

About The National Cancer Institute (NCI)
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat, and prevent cancer. Through its programs and initiatives, the Alliance is committed to building a community of researchers dedicated to using nanotechnology to advance the fight against cancer.

As part of the Center for Strategic Scientific Initiatives, the Alliance for Nanotechnology in Cancer works in concert with other NCI advanced technology initiatives to provide the scientific foundation and team science that is required to transform cancer research and care.

For more information, please click here

Contacts:
National Cancer Institute
Center for Strategic Scientific Initiatives

ATTN: NCI Office of Cancer Nanotechnology Research (OCNR)
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
Telephone: (301) 451-8983

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers."

Related News Press

News and information

The International Space Elevator Consortium (ISEC) is proud to announce the 2014 Space Elevator Conference! This annual event will be held at the Museum of Flight in Seattle, Washington from Friday, August 22nd through Sunday, August 24th August 19th, 2014

KaSAM-2014 International Conference (September 7-10, 2014, Kathmandu, Nepal) August 19th, 2014

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Laboratories

Promising Ferroelectric Materials Suffer From Unexpected Electric Polarizations: Brookhaven Lab scientists find surprising locked charge polarizations that impede performance in next-gen materials that could otherwise revolutionize data-driven devices August 18th, 2014

Research of Empa scientists on the cover of "Nature": Synthesis of structurally pure carbon nanotubes using molecular seeds August 7th, 2014

FEI Reports New Advances in Neuroscience in Collaboration with NIH: Using cryo-electron microscopy, researchers determine the structural mechanism of glutamate receptors – an important insight to the brain’s memory formation and learning August 4th, 2014

New Method Provides Nanoscale Details of Electrochemical Reactions in Electric Vehicle Battery Materials August 4th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Promising Ferroelectric Materials Suffer From Unexpected Electric Polarizations: Brookhaven Lab scientists find surprising locked charge polarizations that impede performance in next-gen materials that could otherwise revolutionize data-driven devices August 18th, 2014

Novel chip-based platform could simplify measurements of single molecules: A nanopore-gated optofluidic chip combines electrical and optical measurements of single molecules onto a single platform August 14th, 2014

Nanomedicine

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

Announcements

Сalculations with Nanoscale Smart Particles August 19th, 2014

Life on Mars? Implications of a newly discovered mineral-rich structure August 19th, 2014

Harris & Harris Group Letter to Shareholders on Website August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE