Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Synthetic hydrogels improve testing of active substances in 3-D cell culture

Abstract:
The life science company Cellendes in Germany has developed synthetic hydrogels that make it possible to culture cells in three-dimensional environments. Their invention has fundamental advantages over other hydrogels for three-dimensional cultivation, also on the market.

Synthetic hydrogels improve testing of active substances in 3-D cell culture

Italy | Posted on May 3rd, 2011

Many researchers culture cells in flat dishes, two-dimensional culture systems. A disadvantage is that the cells behave differently than they would in a living organism. To offer an environment that resembles the living organism better, Dr. Birgitte Angres and Dr. Helmut Wurst have developed synthetic transparent hydrogels for three-dimensional applications within their life science company Cellendes (Cell-Environment-Design).

"Compared to other hydrogels on the market ours can be much easier modified with bioactive factors such as peptides right at the bench. So customers can choose which peptides they want to include in their culture. They can either purchase them from us or have their own being synthesized. Secondly, the concentration of bioactive factors, such as peptides, in our gels can be much higher than in the competitors' gels," Dr. Helmut Wurst said.

The hydrogels are made in a few minutes by combining two solutions in the form of an activated polymer and a cross-linking agent. Through a chemical reaction the polymers use the agent to link themselves together and a three-dimensional network, where the average pore is about eight nanometers wide, forms. Before the linking occurs it is possible to bind biofactors to the polymer and mix in cells.

The biggest challenge, from a technical point of view, during the development of the hydrogels has been to make these components reproducible. "You can do it once and then the next time maybe a little bit different, but you want to make a reproducible quality of your different components and I think that is the biggest problem," Wurst said.

At the moment Wurst and his colleagues are trying to make it possible to store and ship the gels at room temperature and not in refrigerated conditions, to save costs in shipping. They also want to make the gels form a little bit slower. "The gels form so fast that it is sometimes difficult to mix the two different solutions completely," Wurst said.

Almost all of Cellendes' customers are doing basic research within the field of the life sciences. However, their hydrogels could also be useful in the chemical industry and within drug and cosmetic development. "Efforts are made to reduce the number of experimental animal testings. In our system the cells are cultured in a more natural environment and could replace certain animal models," Wurst said.

Within the European Commission-funded project ProNano -Promoting Technology Transfer of Nanosciences, Nanotechnologies, Materials and new Production Technologies, Cellendes researchers have been selected to receive coaching to make their results in nanotechnologies reach the market.

####

For more information, please click here

Contacts:
Elisabeth Schmid
Phone: +39 027002572
Fax: +39 027002540
E-mail:

Copyright © youris.com

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Nanomedicine

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Discoveries

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Materials/Metamaterials

Inside tiny tubes, water turns solid when it should be boiling: MIT researchers discover astonishing behavior of water confined in carbon nanotubes November 30th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Uncovering the secrets of friction on graphene: Sliding on flexible graphene surfaces has been uncharted territory until now November 23rd, 2016

2-D material a brittle surprise: Rice University researchers finds molybdenum diselenide not as strong as they thought November 14th, 2016

Announcements

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project