Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Bill & Melinda Gates Foundation funds Portuguese researcher to develop an innovative therapy against HIV/AIDS

João Gonçalves, Lisbon, Portugal
João Gonçalves, Lisbon, Portugal

Abstract:
João Gonçalves, from Faculdade de Farmácia e Instituto de Medicina Molecular, Lisbon, Portugal, to win a Grand Challenges Exploration Award.

Bill & Melinda Gates Foundation funds Portuguese researcher to develop an innovative therapy against HIV/AIDS

Lisbon, Portugal | Posted on April 30th, 2011

Portuguese researcher João Gonçalves is to receive a Grand Challenges Exploration Grants from the Bill & Melinda Gates Foundation. João Gonçalves is Professor at Faculdade de Farmácia de Lisboa and researcher at Instituto de Medicina Molecular in Lisbon, Portugal, and will develop therapeutic nanoparticles to eliminate HIV-1 viruses from infected organisms.

Gonçalves' project Nanotechnology against viral latency: Sensor strategies to eliminate HIV-1 infected cells is one of the 88 grants announced by the Gates Foundation in the sixth funding round of Grand Challenges Explorations, an initiative to help scientists around the world explore bold and largely unproven ways to improve health in developing countries. The initiative is highly competitive, receiving more than 2500 proposals in this round.

HIV-1 virus can remain latent inside infected organisms for several years, integrated in the genome of certain cell types of the immune system, such as T lymphocytes. Presently, it is not know any form to eradicate HIV-1 viruses from infected individuals. The Portuguese researcher and his team at Faculdade de Farmácia / Instituto de Medicina Molecular in Lisbon, Portugal, will now design and develop therapeutic nanoparticles aimed at specifically recognizing - and destroying - HIV-1 infected cells (where the virus has integrated the cells' genome).

These nanoparticles will have two essential molecules: antibodies to specifically recognize the cell types where latent HIV-1 viruses integrate the genome; and a DNA portion encoding information for the production of a toxin which will destroy cells containing HIV-1 viruses. The nanoparticles will be designed in such a way that the toxin production will only be triggered inside cells that actually contain HIV-1 viruses integrated in the genome.

Thus, the therapeutic nanoparticles will target specifically the cell types that HVI-1 viruses infect (due to the action of the specific antibody); and trigger solely the destruction of those cells that actually host HVI-1 viruses (through activation of the toxin production).

Says João Gonçalves, "We are very proud to receive this award. It will allow us to pursue an out-of-the-box, bold approach to fight HIV/AIDS infection, something that is seldom funded by traditional funding schemes. This award also shows that science in Portugal is recognized internationally and that it can be a trigger for the country's development."

"GCE winners are expanding the pipeline of ideas for serious global health and development challenges where creative thinking is most urgently needed. These grants are meant to spur on new discoveries that could ultimately save millions of lives," said Chris Wilson, director of Global Health Discovery at the Bill & Melinda Gates Foundation.

The project will develop two parallel strategies to construct the therapeutic nanoparticles and will have funding of USD 100,000 during 12 months. This is a basic research project, developed in the laboratory, with the possibility of further funding of up to USD 1million, if the research project demonstrates initial success. In this eventual second phase, the nanoparticles will be produced in large scale and efficacy and security tests will be developed.

João Gonçalves is the second resercher from Instituto de Medicina Molecular to be funded by Bill & Melinda gates Foundation. In 2010, Miguel Prudêncio won Grand Challenges Exploration funding to develop a vaccine against malária.

####

For more information, please click here

Contacts:
Marta Agostinho
+351217999411

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

EmTech Asia breaks new barriers with potential applications of space exploration with NASA and MIT February 22nd, 2017

JPK selects compact tensile stage from Deben for their NanoWizard® AFM platform to broaden capabilities for materials characterisation February 22nd, 2017

Nanomedicine

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Announcements

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

GLOBALFOUNDRIES Announces Availability of 45nm RF SOI to Advance 5G Mobile Communications: Optimized RF features deliver high-performance solutions for mmWave beam forming applications in 5G smartphones and base stations February 22nd, 2017

EmTech Asia breaks new barriers with potential applications of space exploration with NASA and MIT February 22nd, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Oxford Instruments announces Dr Brad Ramshaw of Cornell University, as winner of the 2017 Lee Osheroff Richardson Science Prize February 20th, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project