Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Bill & Melinda Gates Foundation funds Portuguese researcher to develop an innovative therapy against HIV/AIDS

João Gonçalves, Lisbon, Portugal
João Gonçalves, Lisbon, Portugal

Abstract:
João Gonçalves, from Faculdade de Farmácia e Instituto de Medicina Molecular, Lisbon, Portugal, to win a Grand Challenges Exploration Award.

Bill & Melinda Gates Foundation funds Portuguese researcher to develop an innovative therapy against HIV/AIDS

Lisbon, Portugal | Posted on April 30th, 2011

Portuguese researcher João Gonçalves is to receive a Grand Challenges Exploration Grants from the Bill & Melinda Gates Foundation. João Gonçalves is Professor at Faculdade de Farmácia de Lisboa and researcher at Instituto de Medicina Molecular in Lisbon, Portugal, and will develop therapeutic nanoparticles to eliminate HIV-1 viruses from infected organisms.

Gonçalves' project Nanotechnology against viral latency: Sensor strategies to eliminate HIV-1 infected cells is one of the 88 grants announced by the Gates Foundation in the sixth funding round of Grand Challenges Explorations, an initiative to help scientists around the world explore bold and largely unproven ways to improve health in developing countries. The initiative is highly competitive, receiving more than 2500 proposals in this round.

HIV-1 virus can remain latent inside infected organisms for several years, integrated in the genome of certain cell types of the immune system, such as T lymphocytes. Presently, it is not know any form to eradicate HIV-1 viruses from infected individuals. The Portuguese researcher and his team at Faculdade de Farmácia / Instituto de Medicina Molecular in Lisbon, Portugal, will now design and develop therapeutic nanoparticles aimed at specifically recognizing - and destroying - HIV-1 infected cells (where the virus has integrated the cells' genome).

These nanoparticles will have two essential molecules: antibodies to specifically recognize the cell types where latent HIV-1 viruses integrate the genome; and a DNA portion encoding information for the production of a toxin which will destroy cells containing HIV-1 viruses. The nanoparticles will be designed in such a way that the toxin production will only be triggered inside cells that actually contain HIV-1 viruses integrated in the genome.

Thus, the therapeutic nanoparticles will target specifically the cell types that HVI-1 viruses infect (due to the action of the specific antibody); and trigger solely the destruction of those cells that actually host HVI-1 viruses (through activation of the toxin production).

Says João Gonçalves, "We are very proud to receive this award. It will allow us to pursue an out-of-the-box, bold approach to fight HIV/AIDS infection, something that is seldom funded by traditional funding schemes. This award also shows that science in Portugal is recognized internationally and that it can be a trigger for the country's development."

"GCE winners are expanding the pipeline of ideas for serious global health and development challenges where creative thinking is most urgently needed. These grants are meant to spur on new discoveries that could ultimately save millions of lives," said Chris Wilson, director of Global Health Discovery at the Bill & Melinda Gates Foundation.

The project will develop two parallel strategies to construct the therapeutic nanoparticles and will have funding of USD 100,000 during 12 months. This is a basic research project, developed in the laboratory, with the possibility of further funding of up to USD 1million, if the research project demonstrates initial success. In this eventual second phase, the nanoparticles will be produced in large scale and efficacy and security tests will be developed.

João Gonçalves is the second resercher from Instituto de Medicina Molecular to be funded by Bill & Melinda gates Foundation. In 2010, Miguel Prudêncio won Grand Challenges Exploration funding to develop a vaccine against malária.

####

For more information, please click here

Contacts:
Marta Agostinho
+351217999411

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Announcements

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

QD Vision Wins Prestigious Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency October 16th, 2014

Beyond LEDs: Brighter, new energy-saving flat panel lights based on carbon nanotubes - Planar light source using a phosphor screen with highly crystalline single-walled carbon nanotubes (SWCNTs) as field emitters demonstrates its potential for energy-efficient lighting device October 14th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE