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Home > News > Nanotechnology for the Treatment of Coronary In stent Restenosis: A Clinical Perspective

April 18th, 2011

Nanotechnology for the Treatment of Coronary In stent Restenosis: A Clinical Perspective

Abstract:
Coronary in stent restenosis remains a significant limitation to the long term efficacy of coronary artery stent placement. In this review the authors review the pathophysiology of coronary instent restenosis, together with an overview of the current treatment modalities.

The potential clinical utility of nanotechnology is also reviewed.The first human safety trial of systemic nanoparticle paclitaxel (nab-paclitaxel) for instent restenosis (SNAPIST-I) is discussed. The results showed no significant adverse advents attributable to the nab-paclitaxel at 10 or 30 mg/m2, although moderate neutropenia, sensory neuropathy and mild to moderate reversible alopecia occurred at higher doses.

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