Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Therapeutic Nanoparticles Targeted to Radiation Treated Tumors

Abstract:
Radiation and chemotherapy are common partners in anticancer therapy for solid tumors, but too often, the combined side effects associated with each mode of therapy can limit how aggressively oncologists can treat their patients. Now, a team of investigators from Vanderbilt University and Washington University in St. Louis, has developed a nanoparticle that only targets irradiated tumors, offering the potential for reducing chemotherapy-associated toxicities and increasing the effectiveness of combination therapy.

Therapeutic Nanoparticles Targeted to Radiation Treated Tumors

Bethesda, MD | Posted on March 26th, 2011

Reporting its work in the Journal of Controlled Release, the team of investigators led by Zhoaozhong Han of Vanderbilt University describes how it used a technology known as "phase display" to identify a short peptide that binds specifically to irradiated tumor cells and used that peptide as an agent to target doxorubicin-containing nanoparticles to radiation-treated cells. Tests using cells grown in culture demonstrated that lipid-based nanoparticles decorated with this peptide do not bind to healthy cells, whether irradiated or not, nor to tumor cells that are not irradiated.

To test if this targeting peptide exhibits the same selectivity in a living animal, the investigators dosed mice bearing human tumors with one of two lipid nanoparticles loaded with the anticancer drug doxorubicin: one nanoparticle was decorated with the targeting peptide, while the "control" nanoparticle was coated with a random peptide that showed no binding preference for a particular type of cell. The researchers also attached a fluorescent probe to the nanoparticles in order to track their accumulation in the animals. Each animal had tumors growing on both sides of the body, with the tumors on only one side receiving radiation therapy.

When injected into the tumor-bearing mice, the targeted liposomes accumulated rapidly around the irradiated tumors but not around the tumors that were not irradiated. Similarly, the untargeted nanoparticles were largely excreted. More importantly, irradiated tumors treated with the targeted nanoparticle showed a marked increase in cell death and a substantial decrease in the number of blood vessels infusing those tumors. The researchers note that the use of anticancer nanoparticles targeted to irradiated tumors may make it possible to lower the dose of radiation used to treat tumors without negatively impacting therapeutic outcomes.

####

About The National Cancer Institute (NCI)
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat, and prevent cancer. Through its programs and initiatives, the Alliance is committed to building a community of researchers dedicated to using nanotechnology to advance the fight against cancer.

As part of the Center for Strategic Scientific Initiatives, the Alliance for Nanotechnology in Cancer works in concert with other NCI advanced technology initiatives to provide the scientific foundation and team science that is required to transform cancer research and care.

For more information, please click here

Contacts:
National Cancer Institute
Center for Strategic Scientific Initiatives
NCI Office of Cancer Nanotechnology Research (OCNR)
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
Telephone: (301) 451-8983

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Tumor-targeted delivery of liposome-encapsulated doxorubicin by use of a peptide that selectively binds to irradiated tumors."

Related News Press

News and information

Terabyte Photonic Dataset Sale July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

Stanford team achieves 'holy grail' of battery design: A stable lithium anode - Engineers use carbon nanospheres to protect lithium from the reactive and expansive problems that have restricted its use as an anode July 27th, 2014

Nanomedicine

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

New imaging agent provides better picture of the gut July 25th, 2014

Discoveries

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Announcements

Terabyte Photonic Dataset Sale July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Research partnerships

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

A*STAR and industry form S$200M semiconductor R&D July 25th, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE