Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors

Abstract:
Using a handheld molecular imaging device in combination with magnetic nanoparticles and a smartphone, a team of investigators from the Massachusetts General Hospital and Harvard Medical School has developed a fast, portable and potentially inexpensive method of detecting cancer from human biopsy samples. Initial results obtained using fine need biopsies taken from human cancer patients show this device trumps traditional pathological methods, both in terms of speed and diagnostic accuracy.

Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors

Bethesda, MD | Posted on March 26th, 2011

Ralph Weissleder, co-principal investigator of the MIT-Harvard Center for Cancer Nanotechnology Excellence, led this development project. He and his colleagues published the results of their work in the journal Science Translational Medicine.

Typically, cancer is diagnosed by collecting human tissue samples, either removed surgically or via a fine needle inserted into a lump, and sending the samples to a histopathology laboratory, where over the course of several days the sample is analyzed using various tissue stains that highlight cellular features characteristic of tumors for visualization under a microscope. Such analysis is not only time-consuming, it is semi-quantitative at best and requires the technical expertise of a trained pathologist.

The new approach to cancer diagnosis pioneered by Dr. Weissleder and his collaborators relies on the exquisite sensitivity afforded by nuclear magnetic resonance spectroscopy (NMR), an analytical technique used routinely by chemists to characterize complex molecules and one that forms the basis of magnetic resonance imaging (MRI). But rather than using a standard, table-sized NMR machine, the Mass General team designed and built a far-less-expensive handheld NMR machine that interfaces with a microfluidic device and sends its results to a smartphone, which is also used to control the device. The device can detect the presence of multiple magnetic nanoparticles, each designed to bind to a specific tumor-associated molecular marker.

In the first round of evaluation, the investigators analyzed fine needle biopsies taken from 50 patients suspected of having malignant abdominal tumors. After a quick preparatory step, the suspension of cells from the biopsy was treated with a mixture of magnetic nanoparticles, each designed to bind to one of nine specific cancer biomarkers, and then injected into the device's microfluidic channels. Data signals from the microNMR machine were sent wirelessly to a smartphone for analysis and readout. The instrument correctly identified all 44 samples diagnosed as malignant by standard histopathology.

Based on the data generated in this first set of experiments, the investigators analyzed fine needle biopsies from an additional 20 patients using just four of the tagged nanoparticles. The results from this experiment were even better, demonstrating 96% diagnostic accuracy, far exceeding the 84% accuracy of histopathology, the gold standard of cancer diagnosis. Moreover, the microNMR-smartphone device provides a diagnosis within an hour, compared to three days to obtain results from histopathology.

####

About The National Cancer Institute (NCI)
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat, and prevent cancer. Through its programs and initiatives, the Alliance is committed to building a community of researchers dedicated to using nanotechnology to advance the fight against cancer.

As part of the Center for Strategic Scientific Initiatives, the Alliance for Nanotechnology in Cancer works in concert with other NCI advanced technology initiatives to provide the scientific foundation and team science that is required to transform cancer research and care.

For more information, please click here

Contacts:
National Cancer Institute
Center for Strategic Scientific Initiatives
NCI Office of Cancer Nanotechnology Research (OCNR)
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
Telephone: (301) 451-8983

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples."

Related News Press

News and information

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

'Pixel' engineered electronics have growth potential: Rice, Oak Ridge, Vanderbilt, Penn scientists lead creation of atom-scale semiconducting composites September 29th, 2014

Imaging

Iranian Scientists Determine Grain Size, Minimize Time of Nanocomposite Synthesis September 29th, 2014

Oxford Instruments launches 3rd annual Indian nanotechnology seminars in Kolkata and Delhi - sharing expertise with Nanotechnology researchers in India September 25th, 2014

Contributing to the spirit of the IYCR 2014 September 24th, 2014

Nanomedicine

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

How things coil: Researchers discover that simulation technology designed for Hollywood can be used as a predictive tool for understanding fundamental engineering problems September 29th, 2014

Discoveries

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Announcements

Ad-REIC vaccine: A magic bullet for cancer treatment September 30th, 2014

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Tools

Iranian Scientists Determine Grain Size, Minimize Time of Nanocomposite Synthesis September 29th, 2014

Oxford Instruments launches 3rd annual Indian nanotechnology seminars in Kolkata and Delhi - sharing expertise with Nanotechnology researchers in India September 25th, 2014

Contributing to the spirit of the IYCR 2014 September 24th, 2014

BSA Distinguished Lecture Tuesday, 10/14: 'LCLS: A Stunning New View Through X-ray Laser Eyes' September 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE