Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Tiny Gems Take Big Step in Battling Cancer: Nanodiamond-drug combo significantly improves treatment of chemotherapy-resistant cancers

Dean Ho
Photo by Andrew Campbell
Dean Ho
Photo by Andrew Campbell

Abstract:
By Megan Fellman

Chemotherapy drug resistance contributes to treatment failure in more than 90 percent of metastatic cancers. Overcoming this hurdle would significantly improve cancer survival rates.

Tiny Gems Take Big Step in Battling Cancer: Nanodiamond-drug combo significantly improves treatment of chemotherapy-resistant cancers

Evanston, IL | Posted on March 9th, 2011

Dean Ho, an associate professor of biomedical engineering and mechanical engineering at Northwestern University, believes a tiny carbon particle called a nanodiamond may offer an effective drug delivery solution for hard-to-treat cancers.

In studies of liver and breast cancer models in vivo, Ho and a multidisciplinary team of scientists, engineers and clinicians found that a normally lethal amount of a chemotherapy drug when bound to nanodiamonds significantly reduced the size of tumors in mice. Survival rates also increased and no toxic effects on tissues and organs were observed.

This is the first work to demonstrate the significance and translational potential of nanodiamonds in the treatment of chemotherapy-resistant cancers. The results will be published March 9 in the journal Science Translational Medicine.

"Our results show the nanodiamond's enormous translational potential towards significantly improving the efficacy of drug-resistant cancer treatment and simultaneously improving safety," said Ho, who led the research and is corresponding author of the paper. "These are critical benefits. We chose to study these chemo-resistant cancers because they remain one of the biggest barriers to treating cancer and improving patient survival."

Ho is with Northwestern's McCormick School of Engineering and Applied Science and is a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Nanodiamonds are carbon-based materials approximately 2 to 8 nanometers in diameter. Each nanodiamond's surface possesses functional groups that allow a wide spectrum of compounds to be attached to it, including chemotherapy agents.

The researchers took these nanodiamonds and reversibly bound the common chemotherapy drug doxorubicin to them using a scalable synthesis process, which enhances sustained drug release.

Ho and his colleagues studied mouse models with liver and breast cancers. In these resistant cancers, drugs are able to get inside the tumors but are kicked right back out because of an innate response in the liver and breast to expel these drugs.

They treated one group of animals with the doxorubicin-nanodiamond complexes and another group with the drug alone. In those treated with the nanodiamond complexes, the chemotherapeutic remained in circulation longer -- up to 10 times longer -- than those treated with the drug alone. In addition, the drug itself was retained within both types of tumors for a significantly longer period of time. Such a high retention rate means a smaller amount of the very toxic drug would need to be administered, thus reducing side effects.

The researchers also found that the drug-nanodiamond complexes had no negative effect on the white blood cell count. This is especially important for cancer treatment: if the white blood cell count drops below a certain level, treatment is stopped due to the risk of major complications.

"Nanodiamonds have excellent biocompatibility, and the process of formulating nanodiamond-drug complexes is very inexpensive," said Edward K. Chow, a postdoctoral fellow with the G.W. Hooper Foundation and the University of California, San Francisco, and first author of the paper. "Nanodiamonds possess numerous hallmarks of an ideal drug delivery system and are promising platforms for advancing cancer therapy."

The National Institutes of Health, the National Science Foundation, the Wallace H. Coulter Foundation, the V Foundation for Cancer Research, the G.W. Hooper Foundation and the American Cancer Society supported the research.

The paper is titled "Nanodiamond Therapeutic Delivery Agents Mediate Enhanced Chemoresistant Tumor Treatment." In addition to Ho and Chow, other authors of the paper are Xue-Qing Zhang, Mark Chen, Robert Lam, Erik Robinson, Houjin Huang and Daniel Schaffer, from Northwestern; Andrei Goga, from the University of California, San Francisco; and Eiji Osawa, from the NanoCarbon Research Institute, Japan.

####

For more information, please click here

Contacts:
Megan Fellman
science and engineering editor

Copyright © Northwestern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

Ageing can drive progress: Population ageing is likely to boost medicine, nanotechnology and robotics, but increase political risks July 27th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

New nontoxic process promises larger ultrathin sheets of 2-D nanomaterials July 27th, 2016

Nanomedicine

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

Discoveries

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

New nontoxic process promises larger ultrathin sheets of 2-D nanomaterials July 27th, 2016

Announcements

Beating the heat a challenge at the nanoscale: Rice University scientists detect thermal boundary that hinders ultracold experiments July 28th, 2016

Ageing can drive progress: Population ageing is likely to boost medicine, nanotechnology and robotics, but increase political risks July 27th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic