Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticles Increase Survival after Blood Loss

Abstract:
In an advance that could improve battlefield and trauma care, scientists at University of California San Diego and Albert Einstein College of Medicine of Yeshiva University have used tiny particles called nanoparticles to improve survival after life-threatening blood loss. Nanoparticles containing nitric oxide (NO) were infused into the bloodstream of hamsters, where they helped maintain blood circulation and protect vital organs. The research was reported in the February 21 online edition of the journal Resuscitation.

Nanoparticles Increase Survival after Blood Loss

San Diego, CA | Posted on March 8th, 2011

The new nanomedicine, tested in this study in animal models, was developed to address the need for better field treatments for cases of massive blood loss, which can cause cardiovascular collapse, also known as hemorrhagic shock. This potentially fatal condition is best treated with infusions of allogeneic blood and other fluids. But such treatments are limited to emergency rooms or trauma centers.

"It is highly impractical to pack these supplies for use in rural emergencies, mass-casualty disasters or on the battlefield," said coauthor Joel Friedman, M.D., Ph.D., professor of physiology & medicine and of medicine and the Young Men's Division Chair in Physiology at Einstein. "Our nanoparticle therapy may offer the potential for saving lives in those situations. It's lightweight and compact and doesn't require refrigeration."

The new therapy counters hemorrhagic shock by increasing the body's levels of NO gas, which, among other physiological functions, relaxes blood vessels and regulates blood pressure.

The gas is generated inside microscopic-sized particles that were developed by the Einstein team. NO is so short-lived that delivering it in therapeutic amounts requires a method of sustained release. The therapy is created by adding the NO-containing nanoparticles to saline solution, which was then infused into the animals. Once in the body, the nanoparticles gradually release a sustained dose of NO to tissues.

The new nanomedicine was successfully tested at UC San Diego in hamsters that had lost half their blood volume.

"Animals given the nanoparticles exhibited better cardiac stability, stronger blood flow to tissues and other measures of hemorrhagic shock recovery compared to controls receiving saline solution minus the nanoparticles," reported Dr. Friedman.

"The NO gas slows the fight-or-flight response to severe bleeding that restricts blood flow, causing hemorrhagic shock irreversibility. This is a significant step to establish the basis for new treatments for hemorrhagic shock; increasing the odds of survival when fluid resuscitation or definitive interventions are not available," said paper coauthor Pedro Cabrales Ph.D., a professor in the Department of Bioengineering from the UC San Diego, Jacobs School of Engineering.

Decreasing vasoconstriction could make modern therapies for treating hemorrhagic shock more effective by allowing blood and other fluids to promptly reach the microcirculation.

Two previously published studies by Dr. Cabrales and Dr. Friedman and colleagues have demonstrated the beneficial effects of IV injected NO-containing nanoparticles for reversing blood substitute-induced hypertension, increasing tissue perfusion and reducing inflammation.

The paper, "Exogenous Nitric Oxide Prevents Cardiovascular Collapse During Hemorrhagic Shock," appears in the Februrary 21, 2011 online edition of Resuscitation. Other Einstein authors of the study were Adam Friedman, M.D. and Parimala Nachuraju, Ph.D.CoauthorPedro Cabrales, Ph.D., of the University of California, San Diego, California, carried out the animal studies.

####

About UCSD
Founded in 1960, the University of California, San Diego is one of the nationís most accomplished research universities, widely acknowledged for its local impact, national influence and global reach. The campus is ideally located near the Pacific Ocean, the U.S.-Mexico border and the Pacific Rim. UC San Diego is renowned for its collaborative, diverse and cross-disciplinary ethos that transcends traditional boundaries in science, arts and the humanities. The universityís award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs. A leader in climate science research, UC San Diego is one of the greenest universities in the nation and promotes sustainability solutions throughout the region and the world.

For more information, please click here

Contacts:
Daniel Kane

Copyright © UCSD

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Nanomedicine

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Tokai University research: Nanomaterial wrap for improved tissue imaging August 21st, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Discoveries

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Announcements

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

DNA sensor system developed for specific and sensitive measurement of cancer-relevant enzyme activity August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

Heating quantum matter: A novel view on topology: Physicists demonstrate how heating up a quantum system can be used as a universal probe for exotic states of matter August 22nd, 2017

Military

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

2-faced 2-D material is a first at Rice: Rice University materials scientists create flat sandwich of sulfur, molybdenum and selenium August 14th, 2017

Moving at the Speed of Light: University of Arizona selected for high-impact, industrial demonstration of new integrated photonic cryogenic datalink for focal plane arrays: Program is major milestone for AIM Photonics August 10th, 2017

Sensing technology takes a quantum leap with RIT photonics research: Office of Naval Research funds levitated optomechanics project August 10th, 2017

Research partnerships

'Nano-hashtags' could provide definite proof of Majorana particles: Eindhoven network of nanowires gives particles the space to exchange places August 23rd, 2017

Lego proteins revealed: Self-assembling protein complexes based on a single mutation could provide scaffolding for nanostructures August 23rd, 2017

A Tougher Tooth: A new dental restoration composite developed by UCSB scientists proves more durable than the conventional material August 22nd, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project