Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles Increase Survival after Blood Loss

Abstract:
In an advance that could improve battlefield and trauma care, scientists at University of California San Diego and Albert Einstein College of Medicine of Yeshiva University have used tiny particles called nanoparticles to improve survival after life-threatening blood loss. Nanoparticles containing nitric oxide (NO) were infused into the bloodstream of hamsters, where they helped maintain blood circulation and protect vital organs. The research was reported in the February 21 online edition of the journal Resuscitation.

Nanoparticles Increase Survival after Blood Loss

San Diego, CA | Posted on March 8th, 2011

The new nanomedicine, tested in this study in animal models, was developed to address the need for better field treatments for cases of massive blood loss, which can cause cardiovascular collapse, also known as hemorrhagic shock. This potentially fatal condition is best treated with infusions of allogeneic blood and other fluids. But such treatments are limited to emergency rooms or trauma centers.

"It is highly impractical to pack these supplies for use in rural emergencies, mass-casualty disasters or on the battlefield," said coauthor Joel Friedman, M.D., Ph.D., professor of physiology & medicine and of medicine and the Young Men's Division Chair in Physiology at Einstein. "Our nanoparticle therapy may offer the potential for saving lives in those situations. It's lightweight and compact and doesn't require refrigeration."

The new therapy counters hemorrhagic shock by increasing the body's levels of NO gas, which, among other physiological functions, relaxes blood vessels and regulates blood pressure.

The gas is generated inside microscopic-sized particles that were developed by the Einstein team. NO is so short-lived that delivering it in therapeutic amounts requires a method of sustained release. The therapy is created by adding the NO-containing nanoparticles to saline solution, which was then infused into the animals. Once in the body, the nanoparticles gradually release a sustained dose of NO to tissues.

The new nanomedicine was successfully tested at UC San Diego in hamsters that had lost half their blood volume.

"Animals given the nanoparticles exhibited better cardiac stability, stronger blood flow to tissues and other measures of hemorrhagic shock recovery compared to controls receiving saline solution minus the nanoparticles," reported Dr. Friedman.

"The NO gas slows the fight-or-flight response to severe bleeding that restricts blood flow, causing hemorrhagic shock irreversibility. This is a significant step to establish the basis for new treatments for hemorrhagic shock; increasing the odds of survival when fluid resuscitation or definitive interventions are not available," said paper coauthor Pedro Cabrales Ph.D., a professor in the Department of Bioengineering from the UC San Diego, Jacobs School of Engineering.

Decreasing vasoconstriction could make modern therapies for treating hemorrhagic shock more effective by allowing blood and other fluids to promptly reach the microcirculation.

Two previously published studies by Dr. Cabrales and Dr. Friedman and colleagues have demonstrated the beneficial effects of IV injected NO-containing nanoparticles for reversing blood substitute-induced hypertension, increasing tissue perfusion and reducing inflammation.

The paper, "Exogenous Nitric Oxide Prevents Cardiovascular Collapse During Hemorrhagic Shock," appears in the Februrary 21, 2011 online edition of Resuscitation. Other Einstein authors of the study were Adam Friedman, M.D. and Parimala Nachuraju, Ph.D.CoauthorPedro Cabrales, Ph.D., of the University of California, San Diego, California, carried out the animal studies.

####

About UCSD
Founded in 1960, the University of California, San Diego is one of the nation’s most accomplished research universities, widely acknowledged for its local impact, national influence and global reach. The campus is ideally located near the Pacific Ocean, the U.S.-Mexico border and the Pacific Rim. UC San Diego is renowned for its collaborative, diverse and cross-disciplinary ethos that transcends traditional boundaries in science, arts and the humanities. The university’s award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs. A leader in climate science research, UC San Diego is one of the greenest universities in the nation and promotes sustainability solutions throughout the region and the world.

For more information, please click here

Contacts:
Daniel Kane

Copyright © UCSD

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Nanomedicine

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Discoveries

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Military

NanoTechnology for Defense (NT4D) October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

1980s aircraft helps quantum technology take flight October 20th, 2014

Research partnerships

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Nitrogen Doped Graphene Characterized by Iranian, Russian, German Scientists October 21st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE